Effect of Parisheka, Rakta Mokshana and Shamanoushadhi in management of Vicharchika (Eczema) : A Case Report

Introduction: Vicharchika is one among the eleven Kshudra Kushta. Cardinal features of Vicharchika are Kandu, Pidika, Shyava Varna, Bahusravi. Vicharchika is a Kapha Dosha predominant condition as mentioned by Acharya Charaka. Methods: The patient was treated with Siravedha, Sheeta Parisheka with Panchavalkala Qwatha, Gandhaka Rasayana, Triphala Guggulu, Patolakaturohiniyadi Kashaya as Shamana Aushadhi for seven days. Assessment was done on 1st day and 8th day on bases of lakshana, EASI score. Result: After seven days of treatment there was significant reduction in the signs and symptoms, along with EASI score. Discussion: Siravedha was done on the first day in order to eliminate the Dooshita Rakta, later on Sheeta Parisheka was done to pacify the Daha over the lesion for next 6 days. Panchavalkala Qwatha was used for Sheeta Parisheka. Shamanoushadhi prescribed were Gandhaka Rasayana which is Kapha Hara due to its Katu, Tikta Rasa and Ushna Veerya. Triphala Guggulu which acts as Kaphahara due to its Kashaya, Katu, and Tikta Rasa, Rooksha Guna. Patolakaturonhinyadi Kashaya which is Kaphapitta Hara due to its Tikta Rasa and Rooksha Guna. After seven days of treatment patients got significant relief in many cardinal symptoms like Kandu, Srava & Daha. Combined effect of Rakta Mokshana, Parisheka and Shamanoushadhi were considerable improvement seen in this case

Vanadium Dioxide Cathodes for High-Rate Photo-Rechargeable Zinc-Ion Batteries

Photovoltaics are an important source of renewable energy, but due the intermittent nature of insolation, solar cells usually need to be connected to rechargeable batteries, electrochemical capacitors or other energy storage devices, which adds to the complexity and cost of these systems. In this work, we report a cathode design for photo-rechargeable zinc-ion batteries (photo-ZIBs) that is inherently capable of harvesting sunlight to recharge without the need for external solar cells. The proposed photocathodes comprising a composite of vanadium dioxide nanorods and reduced graphene oxide, are engineered to provide the necessary charge separation and storage for photocharging under illumination. The photo-ZIBs achieve gravimetric capacities of ~ 282 mAh g-1 in the dark and ~ 315 mAh g-1 under illumination, at 200 mA g-1, demonstrating the use of light not only to charge the deceives, but additionally to enhance their capacity. The photo-ZIBs also demonstrate enhanced high-rate capabilities under illumination, as well as a capacity retention of ∼ 90% over 1000 cycles. The proposed photo-ZIBs demonstrate a promising new technology for addressing energy poverty, due to their high performance and inherent cost-efficiency and safety.Newton International Fellowship-Royal Society (UK) grant NIF∖R1∖181656 ERC Consolidator grant MIGHTY - 866005 EPSRC Graphene CDT EP/L016087/

STEREOSELECTIVE INTRAMOLECULAR HETERO-DIELS-ALDER REACTIONS OF 1-OXA-1,3-BUTADIENES - SYNTHESIS OF NOVEL ANNELATED PYRROLO[1,2-A]INDOLES

14Novelclassesofpyrano-1,3-dioxane-,pyranopyrimidine-andpyranopyrazole-fusedpyrrolo[1,2-a]indolesaresynthesised via stereoselective intramolecular 1-oxa-1,3-butadiene hetero Diels 13Alder reaction

Advances in CO2 activation by frustrated Lewis pairs: from stoichiometric to catalytic reactions

The rise of CO2 concentrations in the environment due to anthropogenic activities results in global warming and threatens the future of humanity and biodiversity. To address excessive CO2 emissions and its effects on climate change, efforts towards CO2 capture and conversion into value adduct products such as methane, methanol, acetic acid, and carbonates have grown. Frustrated Lewis pairs (FLPs) can activate small molecules, including CO2 and convert it into value added products. This review covers recent progress and mechanistic insights into intra- and inter-molecular FLPs comprised of varying Lewis acids and bases (from groups 13, 14, 15 of the periodic table as well as transition metals) that activate CO2 in stoichiometric and catalytic fashion towards reduced products

Determinants of impact : towards a better understanding of encounters with the arts

The article argues that current methods for assessing the impact of the arts are largely based on a fragmented and incomplete understanding of the cognitive, psychological and socio-cultural dynamics that govern the aesthetic experience. It postulates that a better grasp of the interaction between the individual and the work of art is the necessary foundation for a genuine understanding of how the arts can affect people. Through a critique of philosophical and empirical attempts to capture the main features of the aesthetic encounter, the article draws attention to the gaps in our current understanding of the responses to art. It proposes a classification and exploration of the factors—social, cultural and psychological—that contribute to shaping the aesthetic experience, thus determining the possibility of impact. The ‘determinants of impact’ identified are distinguished into three groups: those that are inherent to the individual who interacts with the artwork; those that are inherent to the artwork; and ‘environmental factors’, which are extrinsic to both the individual and the artwork. The article concludes that any meaningful attempt to assess the impact of the arts would need to take these ‘determinants of impact’ into account, in order to capture the multidimensional and subjective nature of the aesthetic experience

Single domain antibody multimers confer protection against rabies infection

Post-exposure prophylactic (PEP) neutralizing antibodies against Rabies are the most effective way to prevent infection-related fatality. The outer envelope glycoprotein of the Rabies virus (RABV) is the most significant surface antigen for generating virus-neutralizing antibodies. The small size and uncompromised functional specificity of single domain antibodies (sdAbs) can be exploited in the fields of experimental therapeutic applications for infectious diseases through formatting flexibilities to increase their avidity towards target antigens. In this study, we used phage display technique to select and identify sdAbs that were specific for the RABV glycoprotein from a naïve llama-derived antibody library. To increase their neutralizing potencies, the sdAbs were fused with a coiled-coil peptide derived from the human cartilage oligomeric matrix protein (COMP48) to form homogenous pentavalent multimers, known as combodies. Compared to monovalent sdAbs, the combodies, namely 26424 and 26434, exhibited high avidity and were able to neutralize 85-fold higher input of RABV (CVS-11 strain) pseudotypes in vitro, as a result of multimerization, while retaining their specificities for target antigen. 26424 and 26434 were capable of neutralizing CVS-11 pseudotypes in vitro by 90–95% as compared to human rabies immunoglobulin (HRIG), currently used for PEP in Rabies. The multimeric sdAbs were also demonstrated to be partially protective for mice that were infected with lethal doses of rabies virus in vivo. The results demonstrate that the combodies could be valuable tools in understanding viral mechanisms, diagnosis and possible anti-viral candidate for RABV infection

Valorisation of Biowastes for the Production of Green Materials Using Chemical Methods

With crude oil reserves dwindling, the hunt for a sustainable alternative feedstock for fuels and materials for our society continues to expand. The biorefinery concept has enjoyed both a surge in popularity and also vocal opposition to the idea of diverting food-grade land and crops for this purpose. The idea of using the inevitable wastes arising from biomass processing, particularly farming and food production, is, therefore, gaining more attention as the feedstock for the biorefinery. For the three main components of biomass—carbohydrates, lipids, and proteins—there are long-established processes for using some of these by-products. However, the recent advances in chemical technologies are expanding both the feedstocks available for processing and the products that be obtained. Herein, this review presents some of the more recent developments in processing these molecules for green materials, as well as case studies that bring these technologies and materials together into final products for applied usage