Using Analytic Narratives in Policy Analysis: An Explanation of the Implementation of the Water Reform in Italy (1994-2002)

Various critiques have been made of the analytic narrative, which is a methodological approach that combines historically oriented research with rational choice models. This paper discusses strengths and limitations of the approach and provides some suggestions for its inclusion in the repertoire of methodological tools at disposal for comparative policy studies. The argument is supported by evidence provided by the case study of the implementation of the water reform in Italy in the period 1994-2002. The case study shows how the interplay of game theoretic modeling and historical analysis results in the formulation of tentative hypotheses for explaining variation in the observed trajectory of policy reform implementation across time and space

The same deep water as you? The impact of alternative governance arrangements of water service delivery on efficiency

This work contributes to the literature on water governance by attempting to provide an answer to the question of what are the differences in efficiency of alternative governance arrangements of water utilities. We test hypotheses derived from property rights, principal–agent, and transaction costs theories using a comprehensive database of 260 water utility systems provided by the Portuguese Regulatory Authority of Water and Waste Services. Using endogenous switching regression models estimated through maximum likelihood, the study is designed in two steps. First, we investigate differences in efficiency between in-house options and externalization and find that in-house solutions as a set (direct provision and municipal companies) are more efficient than externalization options (mixed companies and concessions). Second, we test differences in efficiency within both in-house and externalization solutions, and fail to find statistically significant differences in efficiency between in-house bureaucracies and municipal companies and between mixed companies and concessions.The author(s) disclosed receipt of the following financial support for the research, authorship, and/ or publication of this article: This research is partially supported by the “Programa Operacional da Região Norte”, NORTE2020, in the context of project NORTE-01-0145-FEDER-000037 (Smar- tEGOV) and by the Portuguese Science and Technology Foundation (Fundacâo para a Ciência e Tecnologia) [Grant No. PEst-OE/CJP/UI0758/2014]. Any opinions, findings, and conclusions orinfo:eu-repo/semantics/publishedVersio

Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury

Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of shaker-type-potassium channels (Kv1 channels) within the nodal complex of myelinated axons following injury. At the neuroma that forms after damage, expression of Kv1.1 and 1.2 (normally localised to the juxtaparanode) was markedly decreased. In contrast Kv1.4 and 1.6, which were hardly detectable in the naïve state, showed increased expression within juxtaparanodes and paranodes following injury, both in rats and humans. Within the dorsal root (a site remote from injury) we noted a redistribution of Kv1-channels towards the paranode. Blockade of Kv1 channels with α-DTX after injury reinstated hyperexcitability of A-fibre axons and enhanced mechanosensitivity. Changes in the molecular composition and distribution of axonal Kv1 channels, therefore represents a protective mechanism to suppress the hyperexcitability of myelinated sensory axons that follows nerve injury