471 research outputs found
Efficacy, safety and patient reported outcomes (PROS) in adult patients with atopic dermatitis treated with dupilumab at week-52 in usual clinical practice
P15
Background: Dupilumab, an anti-interleikin-4-receptor-a monoclonal antibody, is a new treatment for atopic dermatitis in adults.
Objective: To evaluate – at week 52 – patient reported outcomes, satisfaction, efficacy and safety, with dupilumab in adult patients with moderate-to-severe atopic dermatitis refractory to the usual treatments previously performed under conditions of usual clinical practice.
Methods: Twelve patients were enrolled. Patients from our hospital, under routine clinical practice, were treated with subcutaneous dupilumab 300 mg every 2 weeks. The outcomes were evaluated at baseline, week 4, 8, 12, 16, 28 , 40 and week 52. The variables evaluated were: itch, difficulty to sleep, previous stressful life events, severity (SCORAD), anxiety and depression symptoms (HADS), quality of life (DLQI, EQ5D3L), satisfaction, adherence to the treatment, efficacy and safety.
Results: At week 52 significant improvement was observed in severity, itch, difficulty to sleep, anxiety and depression symptoms, and quality of life. Satisfaction with dupilumab compared to previous treatments was significantly higher in all aspects assessed. No significant dupilumab-induced laboratory abnormalities were noted, and adverse events were mild and transient.
Conclusions: Dupilumab used under routine clinical practice for 52 weeks improved atopic dermatitis signs and symptoms, with a good safety profile and patient satisfaction
HADES RV Programme with HARPS-N at TNG. VII. Rotation and activity of M-Dwarfs from time-series high-resolution spectroscopy of chromospheric indicators
We aim to investigate the presence of signatures of magnetic cycles and
rotation on a sample of 71 early M-dwarfs from the HADES RV programme using
high-resolution time-series spectroscopy of the Ca II H & K and Halpha
chromospheric activity indicators, the radial velocity series, the parameters
of the cross correlation function and the V-band photometry. We used mainly
HARPS-N spectra, acquired over four years, and add HARPS spectra from the
public ESO database and ASAS photometry light-curves as support data, extending
the baseline of the observations of some stars up to 12 years. We provide
log(R'hk) measurements for all the stars in the sample, cycle length
measurements for 13 stars, rotation periods for 33 stars and we are able to
measure the semi-amplitude of the radial velocity signal induced by rotation in
16 stars. We complement our work with previous results and confirm and refine
the previously reported relationships between the mean level of chromospheric
emission, measured by the log(R'hk), with the rotation period, and with the
measured semi-amplitude of the activity induced radial velocity signal for
early M-dwarfs. We searched for a possible relation between the measured
rotation periods and the lengths of the magnetic cycle, finding a weak
correlation between both quantities. Using previous v sin i measurements we
estimated the inclinations of the star's poles to the line of sight for all the
stars in the sample, and estimate the range of masses of the planets GJ 3998 b
and c (2.5 - 4.9 Mearth and 6.3 - 12.5 Mearth), GJ 625 b (2.82 Mearth), GJ 3942
b (7.1 - 10.0 Mearth) and GJ 15A b (3.1 - 3.3 Mearth), assuming their orbits
are coplanar with the stellar rotation.Comment: 19 pages, 16 figures, 10 table
Design and Construction Methods of Caisson-Type Maritime Infrastructures Using GFRP
Glass-fiber-reinforced polymers (GFRPs) are commonly used in various applications in civil-engineering projects. However, they are not common in the construction of civil-marine structures. The GFRP caisson technology was developed for the construction of two mooring dolphins in Puerto el Rosario (Fuerteventura, Spain). Ultraviolet-protected glass-fiber and epoxy resin coats were used to build a 12-m diameter, 13.3-m high cylindrical structure. A finite-element model was used to verify the sandwich composite configuration using the Tsai?Hill criteria?the shear strength of the skins and honeycomb core and the buckling and local failure modes with respect to the composite configuration. This is the first time that the two caissons were designed and built of polymeric materials and installed in a seaport. Accordingly, the construction technique marks a milestone in civil engineering because of its highly innovative nature in addition to significantly reducing the time associated with and the complexity of construction operations
Optimal timing of simethicone administration prior to upper endoscopy: A multicenter, single-blind, randomized controlled trial
Background and study aims Simethicone is useful as premedication for upper endoscopy because of its antifoaming effects. We aimed to evaluate the effect of timing of simethicone administration on mucosal visibility. Patients and methods In this multicenter, randomized, endoscopist-blinded study, patients scheduled for upper endoscopy were randomized to receive 40 mg simethicone at the following time points prior to the procedure: 20 to 30 minutes (early group), 0 to 10 minutes (late group) or 20 mg simethicone at both time points (split-dose group). Images were taken from nine predefined locations in the esophagus, stomach, and duodenum before endoscopic flushing. Each image was scored on mucosal visibility by three independent endoscopists on a 4-point scale (lower scores indicating better visibility), with adequate mucosal visibility defined as a score ≤ 2. Primary outcome was the percentage of patients with adequate total mucosal visibility (TMV), reached if all median subscores for each location were ≤ 2. Results A total of 386 patients were included (early group: 132; late group: 128; split-dose group: 126). Percentages of adequate TMV were 55%, 42%, and 61% in the early, late, and split-dose group, respectively ( P < 0.01). Adequate TMV was significantly higher in the split-dose group compared to the late group ( P < 0.01), but not compared to the early group ( P = 0.29). Differences between groups were largest in the stomach, where percentages of adequate mucosal visibility were higher in the early (68% vs 53%, P = 0.03) and split-dose group (69% vs 53%, P = 0.02) compared to the late group. Conclusions Mucosal visibility can be optimized with early simethicone administration, either as a single administration or in a split-dose regimen
Patient reported outcomes (PROS) in psoriasis patients
P20
Introduction: Psoriasis is a chronic skin disease with negative physical, mental and social manifestations. Method: We carried out a longitudinal and prospective study under routine clinical practice conditions. The objective of the study was to measure quality of life with the Short Form-36 Survey (SF-36) and correlate the results with clinical variables using the PASI and BSA in a group of 17 patients with moderate to severe psoriasis treated with Ustekinumab. Results: In the baseline evaluation we observed the following results: 35.3% reported physical malfunction, 64.7% debilitating pain, 82.3% poor health in general, 76.4% bad vitality, 88.2% social malfunction, 100% emotional malfunction and 82.3% poor mental health. At week 78 we observed the following results: 41.15% reported very good physical functioning, 76.1% no pain, 58.8% good general health, 58.8% very good vitality, 70%, 5% good social functioning, 70.5% good emotional functioning and 52.9% good mental health. Conclusion: We observed that the perception of patients with moderate-severe psoriasis regarding their health at the beginning of treatment with Ustekinumab was poor and that they experienced a significant improvement throughout the successive weeks of treatment
Analysis of metastases rates during follow-up after endoscopic resection of early "high-risk" esophageal adenocarcinoma
BACKGROUND AND AIMS: After endoscopic resection (ER) of early esophageal adenocarcinoma (EAC), the optimal management of patients with high-risk histological features for lymph node metastases (LNM) (i.e., submucosal invasion, poor differentiation grade, or lymphovascular invasion (LVI)), remains unclear. We aimed to evaluate outcomes of endoscopic follow-up after ER for high-risk EAC. METHODS: For this retrospective cohort study, data was collected from all Dutch patients managed with endoscopic follow-up (endoscopy, endoscopic ultrasound) after ER for high-risk EAC between 2008 and 2019. We distinguished 3 groups: intramucosal cancers with high-risk features, submucosal cancers with low-risk features, and submucosal cancers with high-risk features. Primary outcome was the annual risk for metastases during follow-up, stratified for baseline histology. RESULTS: A total of 120 patients met the selection criteria. Median FU was 29 months (IQR 15-48). Metastases were observed in 5/25 (annual risk 6.9%; 95% CI 3.0-15), 1/55 (annual risk 0.7%; 95% CI 0-4.0) and 3/40 (annual risk 3.0%; 95% CI 0-7.0) in high-risk intramucosal, low-risk submucosal, and high-risk submucosal cancers, respectively. CONCLUSIONS: Whereas the annual metastasis rate for high-risk submucosal EAC (3.0%) was somewhat lower than expected in comparison with previous reported percentages, the annual metastasis rate of 6.9% for high-risk intramucosal EAC is new and worrisome. This calls for further prospective studies and suggests that strict follow-up of this small subgroup is warranted until prospective data are available
Production and Decay of Scalar Stoponium Bound States
In this paper we discuss possible signatures for the production of scalar
\stst\ (stoponium) bound states \sigst\ at hadron colliders, where \st\ is the
lighter scalar top eigenstate. We first study the decay of \sigst; explicit
expressions are given for all potentially important decay modes. If \st\ has
unsuppressed two--body decays, they will always overwhelm the annihilation
decays of \sigst. Among the latter, we find that usually either the or
final state dominates, depending on the size of the off--diagonal entry of
the stop mass matrix; is the lighter neutral scalar Higgs boson of the
minimal supersymmetric model. If \msig\ happens to be close to the mass of one
of the neutral scalar Higgs bosons, final states dominate ( or
). \ww\ and final states are subdominant. We argue that \sigst
\rightarrow \gamgam decays offer the best signal for stoponium production at
hadron colliders. The tevatron should be able to close the light stop window
left open by LEP searches, but its mass reach is limited to \msig \leq 90
GeV. In contrast, at the LHC one should ultimately be able to probe the region
\msig \leq 700 GeV, if the partial width is not too large. We also
comment on the feasibility of searching for \sigst\ production at hadron
colliders in the and \fourtau\ final states, and briefly
mention \sigst\ production at \gamgam\ colliders.Comment: 31 pages plus 10 figures (available from DREES@WISCPHEN); LaTeX with
equation.sty; MAD/PH/808, KEK-TH-37
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