Создание синтетического аналога интерлейкина-4

Целью исследовательской работы является описание методики создания синтетическогоаналога человеческого интерлейкина- 4, который будет использован для нанесения на поверхность биоматериалов на основе биодеградируемых полимеров с целью придания иммуномодулирующих свойств и увеличения биосовместимости

A New Approach to Harness Probiotics Against Common Bacterial Skin Pathogens: Towards Living Antimicrobials

In this study, the potential of certain lactic acid bacteria—classified as probiotics and known to be antimicrobially active against pathogens or food-poisoning microorganisms—was evaluated with respect to their activity against bacterial skin pathogens. The aim of the study was to develop a plaster/bandage for the application of inhibitory substances produced by these probiotics when applied to diseased skin. For this purpose, two Streptococcus salivarius strains and one Lactobacillus plantarum were tested for production of antimicrobials (bacteriocin-like substances) active against Gram-positive and Gram-negative pathogens using established methods. A newly designed membrane test ensured that the probiotics produce antimicrobials diffusible through membranes. Target organisms used were Cutibacterium acnes, Staphylococcus aureus, and Pseudomonas aeruginosa. Moreover, the L. plantarum 8P-A3 strain was tested against additional bacteria involved in skin disorders. The Lactobacillales used were active against all potential skin pathogens tested. These probiotics could be enclosed between polymer membranes—one tight, the other permeable for their products, preserved by vacuum drying, and reactivated after at least three months storage. Importantly, the reactivated pads containing the probiotics demonstrated antibacterial activity on agar plates against all pathogens tested. This suggests that the probiotic containing pads may be topically applied for the treatment of skin disorders without the need for a regular antibiotic treatment or as an adjunctive therapy

Investignation of applicability of solid state phantom SP34 for orthovoltage X-Ray

It is now widely used two types of tissue-equivalent phantoms: Solid and water. Water is the "gold standard" in accordance with the recommendations of the IAEA as a medium for measurements of absorbed dose for both photon and electron beams for, as the water has the most similar to human tissue characteristics. However, from a practical standpoint, water phantom is not always convenient to use, because it requires much time for preparation work. The output in such a situation would be to use a solid-state phantom with coefficients that take into account the difference between the electronic and physical material density against distilled water

Peculiarities of temperature fields formation in vapor channels of thermosyphons with heat carriers boiling at low temperatures

We conducted experiments on specially developed setup consisting of evaporation, transport and condensation parts. Heat was supplied to the evaporation part by the heating element which was supplied with voltage and alternating current from a single-phase transformer. Temperatures in the characteristic sections of each part were recorded by thermocouples. Junctions of thermocouples were mounted on the axis of symmetry in the liquid layer, at the lower boundary, in the middle part, and at the upper boundary of the vapor channel. To minimize the influence of the random factors (ambient air movement, operation of ventilation system, room temperature, etc.), we placed thermosyphon in a glass box. We used N-pentane as a heat carrier, and the filling ratio of the thermosyphon is equal to 4%