Epidemiological Analysis of Penile Neoplasms in Brazil and Its Social Determinants

Introduction: Penile neoplasms, although preventable, are frequent even among young persons. Penile neoplasms have a high risk of not only morbidity and mortality but also important psychosocial repercussions.Objective: To describe the epidemiology of penile neoplasms in Brazil. Method: This was an epidemiological, descriptive and cross-sectional study. Data on all the notified cases of penile neoplasms in Brazil between 1985 and 2015 were obtained from RCPBP/INCA and DATASUS databases.Results: Of 9 625 notified cases of penile neoplasms, a higher proportion of cancer patients was observed among patients aged between 40 and 70 years (63.5%) and among smokers (21%), in Brown and Caucasian patients (80%), those who were married (54.2%), had high alcohol intake levels (16%) and with lower levels of education: illiterate people (21.5%), those with incomplete elementary school education (36.6%) and those with complete elementary school education (10.3%). The lesions were located in the glans (22.6%), prepuce (7.5%) and the penile body (7.5%). Higher mortality rates were observed in the age-group 50 to 80 years and in among patients from the Northeast (31.4%) and Southeast (39.2%) regions of the country.Conclusion: Penile neoplasms, which mainly affect young people that are economically active, are prevalent in Brazil and the majority of patients present with an advanced stage of the disease. They are Brown and Caucasian, married, with poor education and live in the Northeast and Southeast regions of the country

An association study of FOXO3 variant and longevity

Abstract Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with FOXO3 GT genotype had low levels of triglycerides. This study is the first to demonstrate that FOXO3 could be a candidate gene for longevity in the Brazilian population. These results are important in terms of provisions of health care for age-related diseases and lifespan, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-old individuals

An association study of FOXO3 variant and longevity

<div><p>Abstract Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with FOXO3 GT genotype had low levels of triglycerides. This study is the first to demonstrate that FOXO3 could be a candidate gene for longevity in the Brazilian population. These results are important in terms of provisions of health care for age-related diseases and lifespan, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-old individuals.</p></div

An association study of FOXO3 variant and longevity

<div><p>Abstract Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with FOXO3 GT genotype had low levels of triglycerides. This study is the first to demonstrate that FOXO3 could be a candidate gene for longevity in the Brazilian population. These results are important in terms of provisions of health care for age-related diseases and lifespan, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-old individuals.</p></div