Covid-19 control measures and its impact on seafarers’ mental health

The appearance of COVID-19 in maritime transport has been an exceptional challenge for all stakeholders in this sector, mainly for seafarers who have been caught between the need to keep supply chains operational and the limitations imposed by administrations to prevent the spread of the virus. With these objectives in mind, international institutions and organizations have developed a long series of regulations that have emerged in parallel with the measures established to control the pandemic. This article compiles the recommendations and regulations on health management established for this sector, as well as the implications of this entire process on fatigue and stress in seafarers.  Issues such as difficulties experienced in crew changes and repatriation, extended working hours, social isolation caused by mobility limitations in ports, limited medical equipment and services available, health care restrictions in some ports, the need to quarantine, and the possibility of being infected have been reported, among others, as causes of increased fatigue and stress among seafarers, as well as an upturn in anxiety, depression and other psychiatric disorders in this group. Thus, despite the efforts of the international maritime community to regulate the problematic areas related to the outbreak of the pandemic with the aim of keeping seafarers free of coronavirus and facilitating the continuity of maritime transport, its levels of fatigue and stress have increased notably, demonstrating that these efforts have neither been sufficient nor effective regulations have been developed that specifically take into account how COVID-19 and actions aimed at the continuity of maritime transport have affected and may continue to affect seafarers’ mental health.Peer Reviewe

Vortex breakdown in a water-spout flow

The numerical study of the steady axisymmetric air-water flow in a vertical sealed cylinder, driven by the rotating top disk, describes topological transformations as the rotation intensifies. The air meridional flow (AMF) and swirl induce meridional motions of opposite directions in water. For slow (fast) rotation, the effect of AMF (swirl) dominates. For very fast rotation, large-scale regions of clockwise meridional circulation in air and water are separated by a thin layer of anticlockwise circulation adjacent to the interface in water. This pattern develops for other fluids as well. Physical reasoning behind the flow evolution is provided

The onset of electrospray: the universal scaling laws of the first ejection

The disintegration of liquid drops with low electrical conductivity and subject to an electric field is investigated both theoretically and experimentally. This disintegration takes place through the development of a conical cusp that eventually ejects an ultrathin liquid ligament. A first tiny drop is emitted from the end of this ligament. Due to its exceptionally small size and large electric charge per unit volume, that drop has been the object of relevant recent studies. In this paper, universal scaling laws for the diameter and electric charge of the first issued droplet are proposed and validated both numerically and experimentally. Our analysis shows how charge relaxation is the mechanism that differentiates the onset of electrospray, including the first droplet ejection, from the classical steady cone-jet mode. In this way, our study identifies when and where charge relaxation and electrokinetic phenomena come into play in electrospray, a subject of live controversy in the field.Ministerio de Economía y Competitividad DPI2013-4648

Vortex breakdown in a water-spout flow

The numerical study of the steady axisymmetric air-water flow in a vertical sealed cylinder, driven by the rotating top disk, describes topological transformations as the rotation intensifies. The air meridional flow (AMF) and swirl induce meridional motions of opposite directions in water. For slow (fast) rotation, the effect of AMF (swirl) dominates. For very fast rotation, large-scale regions of clockwise meridional circulation in air and water are separated by a thin layer of anticlockwise circulation adjacent to the interface in water. This pattern develops for other fluids as well. Physical reasoning behind the flow evolution is provided

A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs

Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by double-strand breaks (DSBs). Inaccuracies in this process can drive aneuploidy and developmental defects, but how meiotic cells are protected from unscheduled DNA breaks remains unexplored. Here we define a checkpoint response to persistent meiotic DSBs in C. elegans that phosphorylates the synaptonemal complex (SC) to switch repair partner from the homolog to the sister chromatid. A key target of this response is the core SC component SYP-1, which is phosphorylated in response to ionizing radiation (IR) or unrepaired meiotic DSBs. Failure to phosphorylate (syp-16A) or dephosphorylate (syp-16D) SYP-1 in response to DNA damage results in chromosome non-dysjunction, hyper-sensitivity to IR-induced DSBs, and synthetic lethality with loss of brc-1BRCA1. Since BRC-1 is required for inter-sister repair, these observations reveal that checkpoint-dependent SYP-1 phosphorylation safeguards the germline against persistent meiotic DSBs by channelling repair to the sister chromatid.Cancer Research UK FC0010048UK Medical Research Council FC0010048Wellcome Trust FC0010048Ministerio de Economía y Competitividad BFU2016-75058-PEuropean Research Council ERC2014 AdG669898 TARLOO

Modelos predictivos y técnicas de minería de datos para la identificación de factores asociados al rendimiento académico de alumnos universitarios

Este proyecto tiene por objetivo construir modelos predictivos del rendimiento académico de los estudiantes de las diversas carreras de la FACENA de la UNNE. Las variables a incorporar en los modelos serán seleccionadas de acuerdo a los resultados obtenidos a partir de los siguientes análisis: a) Resultados del test de diagnóstico de conocimientos matemáticos previos; b) Condiciones socioeconómicas de los alumnos de las distintas carreras y datos obtenidos de encuesta directa a los alumnos de primer año. Para la formulación y ajustes de los modelos de predicción, se utilizarán alternativamente, técnicas de minería de datos clásicas y métodos simbólicos o inteligentes, evaluando su desempeño en la predicción del rendimiento académico de los alumnos. Los resultados obtenidos a partir del desarrollo de este proyecto, constituirán un aporte significativo para los procesos de evaluación y acreditación universitarios, considerando que la reflexión sobre todos los elementos proporcionados por el análisis del rendimiento del alumnado contribuirá a la mejora de la calidad del sistema educativo.Eje: Tecnología Informática Aplicada en EducaciónRed de Universidades con Carreras en Informática (RedUNCI

Apuntes para una metafísica elemental

T. I: Metafísica general y cosmología (438 p.) -- T. II: Psicología y Teodicea (358 p.)Copia digital. España : Ministerio de Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 2020Se deduce impreso probablemente ca. 1896-1900 por citar en el prólogo la fecha de 1892 como de cuatro años ante

The JNK inhibitor, SP600125, potentiates the glial response and cell death induced by methamphetamine in the mouse striatum

This study investigates the effect of the selective Jun NH2-terminal kinase 1/2 (JNK1/2) inhibitor, (SP600125) on the striatal dopamine nerve terminal loss and on the increased interleukin-15 (IL-15) expression and glial response induced by methamphetamine (METH). Mice were given repeated low doses of METH (4Â mg/kg, i.p., three times separated by 3Â h) and killed 24Â h or 7 d after the last dose. SP600125 (30Â mg/kg, i.p) was administered 30Â min before the last METH injection. Results indicate that METH produced dopaminergic axonal neurotoxicity reflected as a marked decrease in the striatal density of tyrosine hydroxylase-immunoreactive (TH-ir) fibres and dopamine transporter-immunoreactivity (DAT-ir) 24Â h after dosing. These effects were not modified by SP600125. This compound also failed to prevent the long-term loss of dopamine levels and DAT observed 7 d following METH injection. Nevertheless, SP600125 potentiated METH-induced striatal cell loss reflected by an increase in Fluoro-Jade immunostaining, cleaved capase-3 immunoreactivity and the number of terminal deoxyncleotidyl transferase-mediated dUTP nick end labelling (TUNEL) positive cells. In line with a deleterious effect of JNK1/2 inhibition, SP600125 increased the astroglial and microglial response induced by METH and interfered with drug-induced IL-15 expression. Together these data indicate that, not only does SP600125 fail to protect against the dopaminergic damage induced by METH but also, in fact, it potentiates the glial response and the non-dopaminergic striatal cell loss caused by the drug. © 2013 CINP.Peer Reviewe