Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study.

Low blood dehydroepiandrosterone sulfate (DHEAS) levels have strong positive associations with stroke and coronary heart disease. However, it is unclear whether DHEAS is independently associated with cardiovascular risk factors. Therefore, we examined the association between cardiovascular risk factors and DHEAS concentration among a high-risk population of Latinos (Puerto Ricans aged 45 to 75 years at baseline) in a cross-sectional analysis of the Boston Puerto Rican Health Study. Of eligible participants, 72% completed baseline interviews and provided blood samples. Complete data were available for 1355 participants. Associations between cardiovascular risk factors (age, sex, total cholesterol, high-density lipid cholesterol, triglycerides, and glucose) and log-transformed DHEAS (μg/dL) were assessed. In robust multivariable regression analyses, DHEAS was significantly inversely associated with age (β = -12.4; 95% CI: -15.2, -9.7; per 5 years), being female (vs. male) (β = -46; 95% CI: -55.3, -36.6), and plasma triglyceride concentration (β = -0.2; 95% CI: -0.3, -0.1; per 10 mg/dL) and was positively associated with total cholesterol and plasma glucose levels (β = 1.8; 95% CI: 0.6, 3 and β = 0.2; 95% CI: 0.04, 0.3, respectively, per 10 mg/dL) after adjustment for smoking, alcohol, and physical activity and for postmenopausal hormone use in women. Estimates were unchanged after adjustment for measures of chronic disease and inflammation. Women exhibited a stronger age-related decline in DHEAS and a positive association with glucose in contrast to findings among men (P interaction < 0.05). In conclusion, in this large study of Latinos with a heavy cardiovascular risk factor burden, we observed significant associations between cardiovascular disease (CVD) risk factors and DHEAS, with variations by sex. These findings improve our understanding of the role DHEAS may play in CVD etiology

Molecules with a peptide link in protostellar shocks: a comprehensive study of L1157

Interstellar molecules with a peptide link -NH-C(=O)-, like formamide (NH$_2$CHO), acetamide (NH$_2$COCH$_3$) and isocyanic acid (HNCO) are particularly interesting for their potential role in pre-biotic chemistry. We have studied their emission in the protostellar shock regions L1157-B1 and L1157-B2, with the IRAM 30m telescope, as part of the ASAI Large Program. Analysis of the line profiles shows that the emission arises from the outflow cavities associated with B1 and B2. Molecular abundance of $\approx~(0.4-1.1)\times 10^{-8}$ and $(3.3-8.8)\times 10^{-8}$ are derived for formamide and isocyanic acid, respectively, from a simple rotational diagram analysis. Conversely, NH$_2$COCH$_3$ was not detected down to a relative abundance of a few $\leq 10^{-10}$. B1 and B2 appear to be among the richest Galactic sources of HNCO and NH$_2$CHO molecules. A tight linear correlation between their abundances is observed, suggesting that the two species are chemically related. Comparison with astrochemical models favours molecule formation on ice grain mantles, with NH$_2$CHO generated from hydrogenation of HNCO.Comment: 11 pages, 9 figures. Accepted for publication in MNRAS Main Journal. Accepted 2014 August 19, in original form 2014 July

1/fα1/f^\alpha noise and integrable systems

An innovative test for detecting quantum chaos based on the analysis of the spectral fluctuations regarded as a time series has been recently proposed. According to this test, the fluctuations of a fully chaotic system should exhibit 1/f noise, whereas for an integrable system this noise should obey the 1/f^2 power law. In this letter, we show that there is a family of well-known integrable systems, namely spin chains of Haldane-Shastry type, whose spectral fluctuations decay instead as 1/f^4. We present a simple theoretical justification of this fact, and propose an alternative characterization of quantum chaos versus integrability formulated directly in terms of the power spectrum of the spacings of the unfolded spectrum.Comment: 5 pages, 3 figures, RevTe

New counterterms induced by trans-Planckian physics in semiclassical gravity

We consider free and self-interacting quantum scalar fields satisfying modified dispersion relations in the framework of Einstein-Aether theory. Using adiabatic regularization, we study the renormalization of the equation for the mean value of the field in the self-interacting case, and the renormalization of the semiclassical Einstein-Aether equations for free fields. In both cases we consider Bianchi type I background spacetimes. Contrary to what happens for {\it free} fields in {\it flat} Robertson-Walker spacetimes, the self-interaction and/or the anisotropy produce non-purely geometric terms in the adiabatic expansion, i.e terms that involve both the metric $g_{\mu\nu}$ and the aether field $u_{\mu}$. We argue that, in a general spacetime, the renormalization of the theory would involve new counterterms constructed with $g_{\mu\nu}$ and $u_{\mu}$, generating a fine-tuning problem for the Einstein-Aether theory

Nonlinear Interaction of Transversal Modes in a CO2 Laser

We show the possibility of achieving experimentally a Takens-Bogdanov bifurcation for the nonlinear interaction of two transverse modes ($l = \pm 1$) in a $CO_2$ laser. The system has a basic O(2) symmetry which is perturbed by some symmetry-breaking effects that still preserve the $Z_2$ symmetry. The pattern dynamics near this codimension two bifurcation under such symmetries is described. This dynamics changes drastically when the laser properties are modified.Comment: 16 pages, 0 figure

Deuterium and 15^{15}N fractionation in N2_2H+^+ during the formation of a Sun-like star

Although chemical models predict that the deuterium fractionation in N$_2$H$^+$ is a good evolutionary tracer in the star formation process, the fractionation of nitrogen is still a poorly understood process. Recent models have questioned the similar evolutionary trend expected for the two fractionation mechanisms in N$_2$H$^+$, based on a classical scenario in which ion-neutral reactions occurring in cold gas should have caused an enhancement of the abundance of N$_2$D$^+$, $^{15}$NNH$^+$, and N$^{15}$NH$^+$. In the framework of the ASAI IRAM-30m large program, we have investigated the fractionation of deuterium and $^{15}$N in N$_2$H$^+$ in the best known representatives of the different evolutionary stages of the Sun-like star formation process. The goal is to ultimately confirm (or deny) the classical "ion-neutral reactions" scenario that predicts a similar trend for D and $^{15}$N fractionation. We do not find any evolutionary trend of the $^{14}$N/$^{15}$N ratio from both the $^{15}$NNH$^+$ and N$^{15}$NH$^+$ isotopologues. Therefore, our findings confirm that, during the formation of a Sun-like star, the core evolution is irrelevant in the fractionation of $^{15}$N. The independence of the $^{14}$N/$^{15}$N ratio with time, found also in high-mass star-forming cores, indicates that the enrichment in $^{15}$N revealed in comets and protoplanetary disks is unlikely to happen at core scales. Nevertheless, we have firmly confirmed the evolutionary trend expected for the H/D ratio, with the N$_2$H$^+$/N$_2$D$^+$ ratio decreasing before the pre-stellar core phase, and increasing monotonically during the protostellar phase. We have also confirmed clearly that the two fractionation mechanisms are not related.Comment: 9 pages, 2 figures, accepted for publication in MNRA

Constraining New Forces in the Casimir Regime Using the Isoelectronic Technique

We report the first isoelectronic differential force measurements between a Au-coated probe and two Au-coated films, made out of Au and Ge. These measurements, performed at submicron separations using soft microelectromechanical torsional oscillators, eliminate the need for a detailed understanding of the probe-film Casimir interaction. The observed differential signal is directly converted into limits on the parameters $\alpha$ and $\lambda$ which characterize Yukawa-like deviations from Newtonian gravity. We find \alpha \lsim 10^{12} for $\lambda \sim 200$ nm, an improvement of $\sim$ 10 over previous limits.Comment: 10 pages, 4 figure

Nonlinear Pseudo-Supersymmetry in the Framework of N-fold Supersymmetry

We recall the importance of recognizing the different mathematical nature of various concepts relating to PT-symmetric quantum theories. After clarifying the relation between supersymmetry and pseudo-supersymmetry, we prove generically that nonlinear pseudo-supersymmetry, recently proposed by Sinha and Roy, is just a special case of N-fold supersymmetry. In particular, we show that all the models constructed by these authors have type A 2-fold supersymmetry. Furthermore, we prove that an arbitrary one-body quantum Hamiltonian which admits two (local) solutions in closed form belongs to type A 2-fold supersymmetry, irrespective of whether or not it is Hermitian, PT-symmetric, pseudo-Hermitian, and so on.Comment: 10 pages, no figures; typos correcte