Brain atrophy after cortical hyperintensities in systemic lupus erythematosus

Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Divisão Geral de Neurologia, Sao Paulo SP, BrazilUniversidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Divisão Geral de Neurologia, Sao Paulo SP, BrazilWeb of Scienc

Outcome Determinants of Stroke in a Brazilian Primary Stroke Center

Background. Stroke mortality in Brazil is one of the highest among Western countries. Nonetheless, stroke outcome determinants are still poorly known in this country. In this study we evaluate outcome determinants of stroke in a primary stroke center in São Paulo, Brazil. Methods. We evaluated demographic, clinical, and outcome data of patients with ischemic stroke (IS), transient ischemic attack (TIA), and intracerebral hemorrhage (ICH) admitted at “Hospital Paulistano,” São Paulo, Brazil. In-hospital mortality and functional outcome determinants were assessed. Univariate and binary logistic regression analysis were performed. Results. Three hundred forty-one patients were included in the study, 52.2% being male with 66.8±15.7 years. The stroke type distribution was IS: 59.2%, TIA: 29.6%, and ICH: 11.1%. ICH was associated with greater severity and poorer functional outcome. The determinants of poorer functional outcome were higher NIHSS, lower Glasgow score, and lower oxygen saturation level. The most important mortality determinant was the presence of visual symptoms. Conclusions. The stroke mortality and stroke outcome determinants found in the present study do not remarkably differ from studies carried out in developed countries. Stroke prognosis studies are crucial to better understand the high burden of stroke in Brazil

Frontal lobes white matter abnormalities mimicking cystic leukodystrophy in Wilson’s disease

Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, Div Neurol Geral, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Neurol & Neurocirurgia, Div Neurol Geral, Sao Paulo, SP, BrazilWeb of Scienc

ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation.

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2015-05-19T19:20:02Z No. of bitstreams: 1 Dutra LM ant-kaurane diterpenes.pdf: 499055 bytes, checksum: 997b925a2d8b2fbcc92a1bb4c34cbb80 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2015-05-19T19:36:45Z (GMT) No. of bitstreams: 1 Dutra LM ant-kaurane diterpenes.pdf: 499055 bytes, checksum: 997b925a2d8b2fbcc92a1bb4c34cbb80 (MD5)Made available in DSpace on 2015-05-19T19:36:45Z (GMT). No. of bitstreams: 1 Dutra LM ant-kaurane diterpenes.pdf: 499055 bytes, checksum: 997b925a2d8b2fbcc92a1bb4c34cbb80 (MD5) Previous issue date: 2014Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, BrasilHospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, BrasilFederal University of Sergipe. Department of Chemistry. Itabaiana, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThis work describes a novel ent-kaurane diterpene, ent-3ß-hydroxy-kaur-16-en-19-al along with five known ent-kaurane diterpenes, ent-3ß,19-dihydroxy-kaur-16-eno, ent-3ß-hydroxy-kaur-16-eno, ent-3ß-acetoxy-kaur-16-eno, ent-3ß-hydroxy-kaurenoic acid and kaurenoic acid, as well as caryophyllene oxide, humulene epoxide II, ß-sitosterol, stigmasterol and campesterol from the stem bark of Annona vepretorum Mart. (Annonaceae). Cytotoxic activities towards tumor B16-F10, HepG2, K562 and HL60 and non-tumor PBMC cell lines were evaluated for ent-kaurane diterpenes. Among them, ent-3ß-hydroxy-kaur-16-en-19-al was the most active compound with higher cytotoxic effect over K562 cell line (IC50 of 2.49 µg/mL) and lower over B16-F10 cell line (IC50 of 21.02 µg/mL)