The Sloan Lens ACS Survey. VI: Discovery and analysis of a double Einstein ring

We report the discovery of two concentric Einstein rings around the gravitational lens SDSSJ0946+1006, as part of the Sloan Lens ACS Survey. The main lens is at redshift zl=0.222, while the inner ring (1) is at zs1=0.609 and Einstein radius $Re_1=1.43\pm0.01"$. The wider image separation ($Re_2=2.07\pm 0.02"$) of the outer ring (2) implies that it is at higher redshift. Its detection in the F814W filter implies zs2<6.9. The configuration can be well described by a total density profile $\rho_{tot} ~ r^-g'$ with $g'=2.00\pm0.03$ and velocity dispersion \sigma_{SIE}=287\pm5\kms. [...] We consider whether this configuration can be used to constrain cosmological parameters exploiting angular distance ratios entering the lens equations. Constraints for SDSSJ0946+1006, are uninteresting due to the sub-optimal lens and source redshifts. We then consider the perturbing effect of the mass associated with Ring 1 building a double lens plane compound lens model. This introduces minor changes to the mass of the main lens and allows to estimate the mass of Ring 1 (\sigma_{SIE,s1}=94\pm30\kms). We examine the prospects of doing cosmography with a sample of 50 double lenses, expected from future space based surveys such as DUNE or JDEM. Taking full account of the model uncertainties, such a sample could be used to measure $\Omega_m$ and $w$ with 10% accuracy, for a flat cosmology

Comparison of acute non-visual bright light responses in patients with optic nerve disease, glaucoma and healthy controls.

This study examined the effect of optic nerve disease, hence retinal ganglion cell loss, on non-visual functions related to melanopsin signalling. Test subjects were patients with bilateral visual loss and optic atrophy from either hereditary optic neuropathy (n = 11) or glaucoma (n = 11). We measured melatonin suppression, subjective sleepiness and cognitive functions in response to bright light exposure in the evening. We also quantified the post-illumination pupil response to a blue light stimulus. All results were compared to age-matched controls (n = 22). Both groups of patients showed similar melatonin suppression when compared to their controls. Greater melatonin suppression was intra-individually correlated to larger post-illumination pupil response in patients and controls. Only the glaucoma patients demonstrated a relative attenuation of their pupil response. In addition, they were sleepier with slower reaction times during nocturnal light exposure. In conclusion, glaucomatous, but not hereditary, optic neuropathy is associated with reduced acute light effects. At mild to moderate stages of disease, this is detected only in the pupil function and not in responses conveyed via the retinohypothalamic tract such as melatonin suppression

A More Fundamental Plane

We combine strong-lensing masses with SDSS stellar velocity dispersions and HST-ACS effective (half-light) radii for 36 lens galaxies from the Sloan Lens ACS (SLACS) Survey to study the mass dependence of mass-dynamical structure in early-type galaxies. We find that over a 180--390 km/s range in velocity dispersion, structure is independent of lensing mass to within 5%. This result suggests a systematic variation in the total (i.e., luminous plus dark matter) mass-to-light ratio as the origin of the tilt of the fundamental plane (FP) scaling relationship between galaxy size, velocity dispersion, and surface brightness. We construct the FP of the lens sample, which we find to be consistent with the FP of the parent SDSS early-type galaxy population, and present the first observational correlation between mass-to-light ratio and residuals about the FP. Finally, we re-formulate the FP in terms of surface mass density rather than surface brightness. By removing the complexities of stellar-population effects, this mass-plane formulation will facilitate comparison to numerical simulations and possible use as a cosmological distance indicator.Comment: 4+epsilon pages, 1 figure, emulateapj. Revised version accepted for publication in the ApJ Letter

Addition of Bevacizumab to Temsirolimus in Kidney Cancer Patients

Treatment of metastatic kidney cancer has changed dramatically in the past years with the use of VEGF-targeted therapies and mTOR inhibitors. However, resistance occurs. We report here two cases of patients who benefited, both on disease control and side effects, from the addition of bevacizumab to temsirolimus, after progression on the mTOR inhibitor alone

The SWELLS survey. IV. Precision measurements of the stellar and dark matter distributions in a spiral lens galaxy

We construct a fully self-consistent mass model for the lens galaxy J2141 at z=0.14, and use it to improve on previous studies by modelling its gravitational lensing effect, gas rotation curve and stellar kinematics simultaneously. We adopt a very flexible axisymmetric mass model constituted by a generalized NFW dark matter halo and a stellar mass distribution obtained by deprojecting the MGE fit to the high-resolution K'-band LGSAO imaging data of the galaxy, with the (spatially constant) M/L ratio as a free parameter. We model the stellar kinematics by solving the anisotropic Jeans equations. We find that the inner logarithmic slope of the dark halo is weakly constrained (gamma = 0.82^{+0.65}_{-0.54}), and consistent with an unmodified NFW profile. We infer the galaxy to have (i) a dark matter fraction within 2.2 disk radii of 0.28^{+0.15}_{-0.10}, independent of the galaxy stellar population, implying a maximal disk for J2141; (ii) an apparently uncontracted dark matter halo, with concentration c_{-2} = 7.7_{-2.5}^{+4.2} and virial velocity v_{vir} = 242_{-39}^{+44} km/s, consistent with LCDM predictions; (iii) a slightly oblate halo (q_h = 0.75^{+0.27}_{-0.16}), consistent with predictions from baryon-affected models. Comparing the stellar mass inferred from the combined analysis (log_{10} Mstar/Msun = 11.12_{-0.09}^{+0.05}) with that inferred from SPS modelling of the galaxies colours, and accounting for a cold gas fraction of 20+/-10%, we determine a preference for a Chabrier IMF over Salpeter IMF by a Bayes factor of 5.7 (substantial evidence). We infer a value beta_{z} = 1 - sigma^2_{z}/sigma^2_{R} = 0.43_{-0.11}^{+0.08} for the orbital anisotropy parameter in the meridional plane, in agreement with most studies of local disk galaxies, and ruling out at 99% CL that the dynamics of this system can be described by a two-integral distribution function. [Abridged]Comment: Accepted for publication in MNRAS. 17 pages, 9 figure

EXCASAFEZONE

Excavation work takes place almost continually in most cities around the Western hemisphere. Many cities are already full of infrastructures, buried networks, and street furniture, so excavation work is not without any thread to the operator and surrounding environment. Small construction sites, for example, are often constrained by operating infrastructure on surface level and underground. Although different agencies and network owners have information about the location of the objects that put excavation work at risk, this information is not centralized. Different organizations manage location information of buried cables, unexploded ordnance, and pollution, for example. This significantly complicates the early-stage planning and last minute risk assessment processes because professionals need to manually collect, assess, and integrate data about subsurface objects into a comprehensive risk assessment. To smoothen this process, ExcaSafeZone project, therefore, develops a system that collects location data, defines expert-based rules for safety risk assessment, and that synthesizes this into an open source prototype that visualized safety risks on a heat map. &nbsp

Cross-talk between signaling pathways leading to defense against pathogens and insects

In nature, plants interact with a wide range of organisms, some of which are harmful (e.g. pathogens, herbivorous insects), while others are beneficial (e.g. growth-promoting rhizobacteria, mycorrhizal fungi, and predatory enemies of herbivores). During the evolutionary arms race between plants and their attackers, primary and secondary immune responses evolved to recognize common or highly specialized features of microbial pathogens (Chisholm et al., 2006), resulting in sophisticated mechanisms of defense

Dual Averaging Method for Online Graph-structured Sparsity

Online learning algorithms update models via one sample per iteration, thus efficient to process large-scale datasets and useful to detect malicious events for social benefits, such as disease outbreak and traffic congestion on the fly. However, existing algorithms for graph-structured models focused on the offline setting and the least square loss, incapable for online setting, while methods designed for online setting cannot be directly applied to the problem of complex (usually non-convex) graph-structured sparsity model. To address these limitations, in this paper we propose a new algorithm for graph-structured sparsity constraint problems under online setting, which we call \textsc{GraphDA}. The key part in \textsc{GraphDA} is to project both averaging gradient (in dual space) and primal variables (in primal space) onto lower dimensional subspaces, thus capturing the graph-structured sparsity effectively. Furthermore, the objective functions assumed here are generally convex so as to handle different losses for online learning settings. To the best of our knowledge, \textsc{GraphDA} is the first online learning algorithm for graph-structure constrained optimization problems. To validate our method, we conduct extensive experiments on both benchmark graph and real-world graph datasets. Our experiment results show that, compared to other baseline methods, \textsc{GraphDA} not only improves classification performance, but also successfully captures graph-structured features more effectively, hence stronger interpretability.Comment: 11 pages, 14 figure

Observation of sub-Bragg diffraction of waves in crystals

We investigate the diffraction conditions and associated formation of stopgaps for waves in crystals with different Bravais lattices. We identify a prominent stopgap in high-symmetry directions that occurs at a frequency below the ubiquitous first-order Bragg condition. This sub-Bragg diffraction condition is demonstrated by reflectance spectroscopy on two-dimensional photonic crystals with a centred rectangular lattice, revealing prominent diffraction peaks for both the sub-Bragg and first-order Bragg condition. These results have implications for wave propagation in 2 of the 5 two-dimensional Bravais lattices and 7 out of 14 three-dimensional Bravais lattices, such as centred rectangular, triangular, hexagonal and body-centred cubic