70 research outputs found
Traffic flow on realistic road networks with adaptive traffic lights
We present a model of traffic flow on generic urban road networks based on
cellular automata. We apply this model to an existing road network in the
Australian city of Melbourne, using empirical data as input. For comparison, we
also apply this model to a square-grid network using hypothetical input data.
On both networks we compare the effects of non-adaptive vs adaptive traffic
lights, in which instantaneous traffic state information feeds back into the
traffic signal schedule. We observe that not only do adaptive traffic lights
result in better averages of network observables, they also lead to
significantly smaller fluctuations in these observables. We furthermore compare
two different systems of adaptive traffic signals, one which is informed by the
traffic state on both upstream and downstream links, and one which is informed
by upstream links only. We find that, in general, both the mean and the
fluctuation of the travel time are smallest when using the joint
upstream-downstream control strategy.Comment: 41 pages, pdflate
Physics, Stability and Dynamics of Supply Networks
We show how to treat supply networks as physical transport problems governed
by balance equations and equations for the adaptation of production speeds.
Although the non-linear behaviour is different, the linearized set of coupled
differential equations is formally related to those of mechanical or electrical
oscillator networks. Supply networks possess interesting new features due to
their complex topology and directed links. We derive analytical conditions for
absolute and convective instabilities. The empirically observed "bull-whip
effect" in supply chains is explained as a form of convective instability based
on resonance effects. Moreover, it is generalized to arbitrary supply networks.
Their related eigenvalues are usually complex, depending on the network
structure (even without loops). Therefore, their generic behavior is
characterized by oscillations. We also show that regular distribution networks
possess two negative eigenvalues only, but perturbations generate a spectrum of
complex eigenvalues.Comment: For related work see http://www.helbing.or
Phase Synchronization in Railway Timetables
Timetable construction belongs to the most important optimization problems in
public transport. Finding optimal or near-optimal timetables under the
subsidiary conditions of minimizing travel times and other criteria is a
targeted contribution to the functioning of public transport. In addition to
efficiency (given, e.g., by minimal average travel times), a significant
feature of a timetable is its robustness against delay propagation. Here we
study the balance of efficiency and robustness in long-distance railway
timetables (in particular the current long-distance railway timetable in
Germany) from the perspective of synchronization, exploiting the fact that a
major part of the trains run nearly periodically. We find that synchronization
is highest at intermediate-sized stations. We argue that this synchronization
perspective opens a new avenue towards an understanding of railway timetables
by representing them as spatio-temporal phase patterns. Robustness and
efficiency can then be viewed as properties of this phase pattern
Random planar graphs and the London street network
In this paper we analyse the street network of London both in its primary and
dual representation. To understand its properties, we consider three idealised
models based on a grid, a static random planar graph and a growing random
planar graph. Comparing the models and the street network, we find that the
streets of London form a self-organising system whose growth is characterised
by a strict interaction between the metrical and informational space. In
particular, a principle of least effort appears to create a balance between the
physical and the mental effort required to navigate the city
Inhibitory and agonistic autoantibodies directed against the ß(2)-adrenergic receptor in pseudoexfoliation syndrome and glaucoma
Pseudoexfoliation syndrome (PEXS) and glaucoma (PEXG) are assumed to be caused by a generalized elastosis leading to the accumulation of PEX material in ocular as well as in extraocular tissues. The exact pathophysiology of PEXS is still elusive. PEXG, the most common type of secondary open-angle glaucoma (OAG), is characterized by large peaks of intraocular pressure (IOP) with a progressive loss of the visual field. Agonistic autoantibodies (agAAbs) against the ß(2)-adrenergic receptor (AR) have been shown to be present in sera of patients with primary and secondary OAG and ocular hypertension and are seemingly linked to IOP. In the present study, we investigated the autoantibodies directed against the ß(2)-AR in sera of patients with PEXS and PEXG. We recruited 15, 10, and 15 patients with PEXG, PEXS, and primary OAG, respectively. Ten healthy individuals served as controls. All patients underwent standard ophthalmological examination with Octopus G1 perimetry. agAAbs prepared from serum samples were analyzed in a rat cardiomyocyte–based bioassay for the presence of agAAbs. We identified the interacting loop of the ß(2)-AR and the immunoglobulin G (IgG) subclasses using synthetic peptides corresponding to the extracellular loops of the receptors and enzyme-linked immunosorbent assay, respectively. None of the controls were ß(2)-agAAb–positive (0.2 ± 0.5 U). No ß(2)-agAAbs (0.2 ± 0.4 U), but inhibitory ß(2)-AAbs were observed in 80% of the patients that partially blocked the drug-induced ß(2)-adrenergic stimulation; 5.8 ± 1.7 U vs. 11.1 ± 0.9 U for clenbuterol in the absence and the presence of sera from patients with PEXS, respectively. Epitope analyses identified the third extracellular loop of the ß(2)-AR as the target of the inhibitory ß(2)-AAbs, being of IgG3 subtype in PEXS patients. In contrast, patients with PEXG showed ß(2)-agAAbs (5.6 ± 0.9 U), but no inhibitory ones. The ß(2)-agAAbs levels of patients with PEXG and primary OAG patients (3.9 ± 2.8 U; p > 0.05) were at a similar level. In two cases of PEXG, the ß(2)-agAAbs exert synergistic effects with clenbuterol. The activity increased from 11.5 ± 0.3 (clenbuterol only) to 16.3 ± 0.9 U. As autoimmune mechanisms were reportedly involved in the pathogenesis of glaucoma, agonistic and inhibitory ß(2)-AAbs seem to be a part of this multifactorial interplay
Agonistic β2-adrenergic receptor autoantibodies characterize the aqueous humor of patients with primary and secondary open-angle glaucoma
PURPOSE: Agonistic β2-adrenergic receptor autoantibodies (β2-agAAbs) were recently observed in sera of patients with ocular hypertension (OHT), primary (POAG), and secondary open-angle glaucoma (SOAG), yet not in healthy controls (HCs). It was the aim of the present study to investigate the presence of β2-agAAb in aqueous humor (AH) samples of OAG patients and to correlate these with the corresponding β2-agAAb serum data. MATERIAL AND METHODS: Thirty-nine patients (21 male, 18 female) were recruited from the Department of Ophthalmology, University of Erlangen-Nürnberg: twenty-one POAG, 18 SOAG. Aqueous humor samples were collected during minimal invasive glaucoma surgery. Serum and AH samples were analyzed for β2-agAAb by a bioassay quantifying the beating rate of cultured cardiomyocyte (cut-off: 2 U). RESULTS: Thirty-six of 39 (92.3%) and 34 of 39 (87.2%) of OAG patients showed a β2-agAAb in their sera and AH samples, respectively. All β2-agAAb AH-positive OAG patients were also seropositive. We also observed a β2-agAAb seropositivity in 95 and 89% of patients with POAG and SOAG, respectively. Beta2-agAAbs were seen in 86% (POAG) and 78% (SOAG) of AH samples. The β2-agAAb adrenergic activity was increased in the AH of patients with POAG (6.5 ± 1.5 U) when compared with those with SOAG (4.1 ± 1.1 U; p = 0.004). Serum β2-agAAb adrenergic activity did not differ between the cohorts [POAG (4.5 ± 1.5 U); SOAG (4.6 ± 2.1 U; p=0.458)]. No correlation of the beating rates were observed between serum and AH samples for group and subgroup analyses. CONCLUSION: The detection of β2-agAAb in systemic and local circulations supports the hypothesis of a direct functional impact of these agAAbs on ocular G-protein coupled receptors. The high prevalence of β2-agAAb in serum and AH samples of patients with POAG or SOAG suggests a common role of these AAbs in the etiopathogenesis of glaucoma, independent of open-angle glaucoma subtype
Self-Control of Traffic Lights and Vehicle Flows in Urban Road Networks
Based on fluid-dynamic and many-particle (car-following) simulations of
traffic flows in (urban) networks, we study the problem of coordinating
incompatible traffic flows at intersections. Inspired by the observation of
self-organized oscillations of pedestrian flows at bottlenecks [D. Helbing and
P. Moln\'ar, Phys. Eev. E 51 (1995) 4282--4286], we propose a self-organization
approach to traffic light control. The problem can be treated as multi-agent
problem with interactions between vehicles and traffic lights. Specifically,
our approach assumes a priority-based control of traffic lights by the vehicle
flows themselves, taking into account short-sighted anticipation of vehicle
flows and platoons. The considered local interactions lead to emergent
coordination patterns such as ``green waves'' and achieve an efficient,
decentralized traffic light control. While the proposed self-control adapts
flexibly to local flow conditions and often leads to non-cyclical switching
patterns with changing service sequences of different traffic flows, an almost
periodic service may evolve under certain conditions and suggests the existence
of a spontaneous synchronization of traffic lights despite the varying delays
due to variable vehicle queues and travel times. The self-organized traffic
light control is based on an optimization and a stabilization rule, each of
which performs poorly at high utilizations of the road network, while their
proper combination reaches a superior performance. The result is a considerable
reduction not only in the average travel times, but also of their variation.
Similar control approaches could be applied to the coordination of logistic and
production processes
Agonistic autoantibodies against β2-adrenergic receptor influence retinal microcirculation in glaucoma suspects and patients
PURPOSE: Agonistic β2-adrenergic receptor autoantibodies (β2-agAAb) have been observed in sera of patients with ocular hypertension and open-angle glaucoma (OAG). They target the β2-receptors on trabecular meshwork, ciliary body and pericytes (Junemann et al. 2018; Hohberger et al. 2019). In addition to their influence on the intraocular pressure, an association to retinal microcirculation is discussed. This study aimed to investigate foveal avascular zone (FAZ) characteristics by en face OCT angiography (OCT-A) in glaucoma suspects and its relationship to β2-agAAb status in patients with OAG. MATERIAL AND METHODS: Thirty-four patients (28 OAG, 6 glaucoma suspects) underwent standardized, clinical examination including sensory testing as white-on-white perimetry (Octopus G1, mean defect, MD) and structural measures as retinal nerve fibre layer (RNFL) thickness, neuroretinal rim width (BMO-MRW), retinal ganglion cell layer (RGCL) thickness, and inner nuclear layer (INL) thickness with high-resolution OCT. FAZ characteristics were measured by OCT-A scans of superficial vascular plexus (SVP), intermediate capillary plexus (ICP), and deep capillary plexus (DCP). FAZ-R was calculated (area FAZ (SVP)/area FAZ (ICP)). Using cardiomyocyte bioassays we analysed serum samples for the presence of β2-agAAb. RESULTS: (I) Total mean FAZ area [mm2]: 0.34±0.16 (SVP), 0.24±0.12 (ICP), and 0.49±0.24 (DCP); mean FAZ-R 1.58±0.94. No correlation was seen for FAZ-R with MD, RNFL, BMO-MRW, RGCL thickness and INL thickness (p>0.05). (II) ß2-agAAb have been observed in 91% patients and showed no correlation with MD, RNFL, BMO-MRW, RGCL thickness and INL thickness (p>0.05). (III) FAZ-R correlated significantly with the β2-agAAb-induced increase of the beat rate of cardiomyocyte (p = 0.028). CONCLUSION: FAZ characteristics did not correlate with any glaucoma associated functional and morphometric follow-up parameter in the present cohort. However, level of β2-agAAb showed a significantly correlation with FAZ-ratio. We conclude that β2-agAAb might be a novel biomarker in glaucoma pathogenesis showing association to FAZ-ratio with OCT-A
Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma
purpose. Three common sequence variants in the lysyl oxidase-like 1 (LOXL1) gene were recently associated with both pseudoexfoliation (PEX) and pseudoexfoliation glaucoma (PEXG) in populations from Iceland and Sweden. In this study, the genetic association of these variants was investigated in patients with PEX or PEXG of German and Italian descent.
methods. The three LOXL1 single-nucleotide polymorphisms (SNPs), one intronic (rs2165241) and two nonsynonymous coding SNPs (rs1048661: R141L and rs3825942: G153D) were genotyped in a total of 726 unrelated patients with PEX or PEXG (517 Germans and 209 Italians) and 418 healthy subjects who had normal findings in repeated ophthalmic examinations, and a genetic association study was performed.
results. Strong association with the three LOXL1 common sequence variants was seen in both the PEX and PEXG patient groups independent of their geographic origin (rs2165241, combined OR = 3.42, P = 1.28 × 10−40; rs1048661, OR = 2.43, P = 2.90 × 10−19; and rs3825942, OR = 4.87, P = 8.22 × 10−23). Similarly, the common frequent haplotype (G-G) composed of the two coding SNPs (rs1048661 and rs3825942) was strongly associated in PEX and PEXG cohorts of both populations with the disease (combined OR = 3.58, P = 5.21× 10−43).
conclusions. Genetic variants in LOXL1 confer risk to PEX in German and Italian populations, independent of the presence of secondary glaucoma, confirming findings in patients from Northern Europe
Urban road networks -- Spatial networks with universal geometric features? A case study on Germany's largest cities
Urban road networks have distinct geometric properties that are partially
determined by their (quasi-) two-dimensional structure. In this work, we study
these properties for 20 of the largest German cities. We find that the
small-scale geometry of all examined road networks is extremely similar. The
object-size distributions of road segments and the resulting cellular
structures are characterised by heavy tails. As a specific feature, a large
degree of rectangularity is observed in all networks, with link angle
distributions approximately described by stretched exponential functions. We
present a rigorous statistical analysis of the main geometric characteristics
and discuss their mutual interrelationships. Our results demonstrate the
fundamental importance of cost-efficiency constraints for in time evolution of
urban road networks.Comment: 16 pages; 8 figure
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