22 research outputs found
Selected copper(I) complexes as potential anticancer agent
Choroby nowotworowe s膮 drug膮 co do cz臋sto艣ci wyst臋powania przyczyn膮 zgon贸w na 艣wiecie. Jednym z metali przej艣ciowych, kt贸rego zwi膮zki kompleksowe s膮 intensywnie badane pod k膮tem zastosowania w terapii antynowotworowej jest mied藕. W artykule, na wybranych przyk艂adach, om贸wiono aktywno艣膰 i mechanizmy cytotoksycznego dzia艂ania kompleks贸w miedzi(I).Cancer is the second most frequent cause of death in the world. One of the transition metal, whose complexes are extensively tested for antitumor application is copper. This article presents selected examples of cytotoxic activity and mode of action of copper(I) complexes
Physicochemical and biological activity analysis of low-density polyethylene substrate modified by multi-layer coatings based on DLC structures, obtained using RF CVD method
In this paper, the surface properties and selected mechanical and biological properties of various multi-layer systems based on diamond-like carbon structure deposited on low-density polyethylene (LDPE) substrate were studied. Plasma etching and layers deposition (incl. DLC, N-DLC, Si-DLC) were carried out using the RF CVD (radio frequency chemical vapor deposition) method. In particular, polyethylene with deposited N-DLC and DLC layers in one process was characterized by a surface hardness ca. seven times (up to ca. 2.3 GPa) higher than the unmodified substrate. Additionally, its surface roughness was determined to be almost two times higher than the respective plasma-untreated polymer. It is noteworthy that plasma-modified LDPE showed no significant cytotoxicity in vitro. Thus, based on the current research results, it is concluded that a multilayer system (based on DLC coatings) obtained using plasma treatment of the LDPE surface can be proposed as a prospective solution for improving mechanical properties while maintaining biocompatibility
Surface functionalization with biopolymers via plasma-assisted surface grafting and plasma-induced graft polymerization : materials for biomedical applications
Wp艂yw parametru procesu PA CVD na szybko艣膰 wzrostu i budow臋 warstw w臋glowych modyfikowanych azotem : rozprawa doktorska /
Praca doktorska. Akademia G贸rniczo-Hutnicza im. Stanis艂awa Staszica (Krak贸w), 2009.Bibliogr. k. 101-107.Warstwy w臋glowe, klasyfikacja, metody otrzymywania warstw z fazy gazowej, metody fizycznego, chemicznego osadzania, mechanizm wzrostu warstw w procesie CVD, reakcje chemiczne w uk艂adzie CVD, struktura warstw w臋glowych, aktualny stan wiedzy, otrzymywanie, budowa warstw w臋glowych a ich w艂a艣ciwo艣ci, aparatura, przygotowanie pod艂o偶y, metodyka badawcza, rezultaty bada艅, dob贸r sk艂adu chemicznego wyj艣ciowych mieszanin gazowych, wp艂yw parametr贸w RF CVD na szybko艣膰 wzrostu warstw, parametr贸w procesu na budow臋 warstw, wst臋pna analiza widm FTIR, wp艂yw temperatury, ci艣nienia, mocy generatora RF, czasu osadzania, parametr贸w RF CVD na struktur臋 warstw, proponowane reakcje chemiczne prowadz膮ce do wzrostu warstw a-C:N:
Structure, characterization and cytotoxicity studies on plasma surface modified Ti-6Al-4V and 纬-TiAl alloys
Surface modification of two titanium alloys (Ti-6Al-4V and 纬-TiAl) was performed by Plasma Assisted Microwave Chemical Vapor Deposition (PA MW CVD) method. The plasma treatment revealed formation of stable surface coatings and significant improvement of mechanical and surface parameters such as: hardness, roughness, surface energy and contact angle, that are crucial in case of application in implantology. Deposition of SiCNH coating on the 纬-TiAl alloy surface, without plasma nitriding process application, resulted in the most hydrophobic structure with the largest surface area. The selected deposition parameters aided the excellent attachment of CT26 cells and promoted their growth