14 research outputs found
Study on the Applicability of Dynamic Stability Evaluation Criteria by Comparison of Trackside Measurement Results of Different Track Structures
Countries such as Korea adopt design codes, evaluation criteria and specifications from standards originating abroad; this leads to a lack of distinction of the separate applications of dynamic stability evaluation parameters between various track structures of different track moduli. This paper discusses the applicability of the dynamic stability evaluation method of railway track structures by assessing 10 different types of railway track sections of a newly constructed railway operation line (5 ballasted and 5 concrete type track structures) by field instrumentation testing. Parameters of track support stiffness (TSS), wheel load fluctuation, derailment coefficient, and rail displacement are measured. The respective results are first compared to the standard criteria (design specification) and comparisons between the different track types are presented as ratios. Findings show that while all of the tracks satisfy the design specification requirements, each track type measurement result varies by a noticeable degree, particularly when comparing between concrete and ballast type track structures. Results of the study demonstrate that using the same dynamic stability evaluation criteria can lead to an incorrect assessment of the track performance evaluation of track structure, and a separate evaluation parameter for ballasted and concrete track structures is required
Study on the Applicability of Dynamic Factor Standards by Comparison of Spring Constant Based Dynamic Factor of Ballasted and Concrete Track Structures
Dynamic factor evaluation method calculation methods outlined by Eisenmann (DAFEisenmann) and the American Railway Engineering Association (DAFArea) are used to calculate the dynamic factor during design and for trackside measurement, respectively, in nations where the construction of concrete track structures is relatively new. In this situation, dynamic factor calculation methods may be incorrect, and this is demonstrated by comparison of the respective track types’ total spring constant. A finite element analysis of a standard design railway track is conducted, and the design total spring constant (TSC, or K) obtained from the time history function analysis is compared to the TSC of existing tracks through trackside measurement results. The comparison result shows that TSC obtained by finite element analysis result is 22% higher than that of the trackside measurement value, indicating that the TSC is conservative in the current track design. Considering the proportional relationship between TSC and dynamic factor, it is estimated that the dynamic factor currently being applied in track design is also conservative. Based on these findings, an assessment of the applicability of different dynamic factors (DAFEisenmann and DAFArea), theoretical calculation and field measurement (DAFField) using the probabilistic analysis of wheel loads from the field measurement data is conducted. A correlative analysis between DAFEisenmann and DAFArea shows that DAFEisenmann and DAFArea were estimated to be higher by 33% and 27% in ballasted track and by 39% and 30% in concrete track than the dynamic factor derived from field measurement, respectively, which indicates that the dynamic factor currently in use can potentially lead to over-estimation in track design and maintenance
Association between Obesity and Carotid Intima-Media Thickness in Korean Office Workers: The Mediating Effect of Physical Activity
Background. Obesity and physical inactivity are associated with higher prevalence of cardiovascular disease (CVD). Objective. This study investigated the association between obesity and carotid intima-media thickness (CIMT) stratified by physical activity (PA) in Korean office workers. Methods. Data obtained from 914 office workers aged 21-60 years (347 women) were used. Resting blood pressures, body mass index (BMI), and waist-to-height ratio (WHtR) were measured. PA was assessed using the international physical activity questionnaire. CIMT was assessed with a carotid artery ultrasonography. Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence interval (CI) of obesity stratified by weekly PA for an abnormally increased CIMT. Results. Logistic regression analyses showed that those who were overall obese (OR=2.50, 95% CI=1.60-3.91, P<0.001) or central obese (OR=2.08, 95% CI=1.29-3.40, P=0.003) had significantly higher estimated risks of having an abnormally increased CIMT even after adjustments for age, sex, smoking, alcohol consumption, resting blood pressures, and history of hypertension, diabetes, and hyperlipidemia, as compared with those who were not overall or central obese (OR=1). A multivariate linear regression suggested that age (P<0.001), sex (P=0.002), hypertension (P=0.014), smoking (P=0.054), BMI (P<0.001), and physical activity (P=0.011) were important determinants of abnormally elevated CIMT in this study population. Conclusion. The current findings suggest that the risk of obesity for an abnormally increased CIMT is significantly modulated by demographics as well as lifestyle-related risk factors including smoking and physical inactivity in Korean office workers
Virus-mimetic polymer nanoparticles displaying hemagglutinin as an adjuvant-free influenza vaccine
The generation of virus-mimetic nanoparticles has received much attention in developing a new vaccine for overcoming the limitations of current vaccines. Thus, a method, encompassing most viral features for their size, hydrophobic domain and antigen display, would represent a meaningful direction for the vaccine development. In the present study, a polymer-templated protein nanoball with direction oriented hemagglutininl on its surface (H1-NB) was prepared as a new influenza vaccine, exhibiting most of the viral features. Moreover, the concentrations of antigen on the particle surface were controlled, and its effect on immunogenicity was estimated by in vivo studies. Finally, H1-NB efficiently promoted H1-specific immune activation and cross-protective activities, which consequently prevented H1N1 infections in mice