Shield or Glue? Key Policy Issues Constraining or Enhancing Multinational Collective Ballistic Missile Defense

This dissertation explores a series of eleven political factors nations would have to consider should they contemplate joining a military coalition or alliance that uses ballistic missile defense (BMD); which of these factors incentivize or dissuade states from joining this coalition, and whether they vary from region to region, or state to state. It uses a two-stage case-study-based qualitative research design, in which the first theory generation phase was comprised of 21 experimentation events over a ten-year period with BMD policy experts from 24 nations led by the United States Strategic Command known as NIMBLE TITAN. The results of these 21 events were used to distill eleven BMD-related policy independent variables affecting the dependent variable, the decision to join a coalition or alliance that uses BMD. The second, data collection phase, interviewed 22 BMD policy experts from the Ministries of Defense and Foreign Affairs of 17 nations and NATO, from four regions including the Asia-Pacific, Europe, the Gulf, and North America. The results of the interviews were used to not only assess these variables as they contributed to the DV, but to create a causal model that looks at those which affect joining a coalition, those which were found to only matter within an existing coalition or alliance, and those which, if handled badly, would incentivize a state to leave a coalition or alliance. This work concludes with a series of recommendations for policy makers who may wish to create such a coalition in the future, and areas for future research. Advisor: Dr. Patrice McMaho

Flow field computations for blunt bodies in planetary environments /equilibrium/ Final report

Radiative and convective heat transfer about two blunt bodies traveling at hypersonic speeds at zero angle of attack in assumed Mars atmosphere of nitrogen and carbon dioxid

Long-term results after 110 tracheal resections

Objective: Among the many therapeutic options for treating tracheal stenosis (e.g. bouginage, laser resection and stenting), segmental resection and reconstruction with end-to-end anastomosis is the method of choice. We verified this in an analysis of clinical material

Expanding Care Coordination Scope to Support Covid-19 Population

Covid-19 has caused overwhelming surges of cases in urban areas across the world. To assist with difficult discharges, as well as avoid unnecessary readmissions and ED visits, the care coordination team has created a comprehensive follow up care pathway across the enterprise to support our COVID-19 patients. This care pathway looks to assist Covid patients by reinforcing self-care management, providing education and supporting adherence with scheduled follow up with a primary care provider. Technology was leveraged to interact virtually with patients who are quarantined at home. Jefferson Abington and Jefferson Northeast partnered with DinaCare to utilize their texting platform to engage patients daily for home monitoring. Symptomatic escalations were reviewed and responded to by the RN team for additional outreach. Jefferson Center City and Jefferson New Jersey leveraged the My Chart app component, Care Companion, to survey patients daily. Patients are to be provided with a Pulse Ox monitor in the ED if necessary. Care coordination then monitors daily vital signs that are self reported by patients and engages the patient as appropriate

Influence of ultra-low dose Aprotinin on thoracic surgical operations: a prospective randomized trial

<p>Abstract</p> <p>Background</p> <p>The blood saving effect of aprotinin has been well documented in cardiac surgery. In thoracic surgery, very few recent studies, using rather high doses of aprotinin, have shown a similar result. In a randomized prospective trial, we have tested the influence of aprotinin using an ultra-low dose drug regime.</p> <p>Methods</p> <p>Fifty-nine patients, mean age 58 ± 13.25 years (mean ± SD) undergoing general thoracic procedures were randomized into placebo (Group A) and treatment group (Group B). The group B (n = 29) received 500.000 IU of aprotinin after induction to anesthesia and a repeat dose immediately after chest closure. A detailed protocol with several laboratory parameters was recorded. Patients were transfused when perioperative Ht was less than 26%.</p> <p>Results</p> <p>The two groups were similar in terms of age, gender, diagnosis, pathology, co-morbidity and operations performed. The mean drainage of the first and second postoperative day in group B was significantly reduced (412.6 ± 199.2 vs. 764.3 ± 213.9 ml, p < 0.000, and 248.3 ± 178.5 vs. 455.0 ± 274.6, p < 0.001). Similarly, the need for fresh frozen plasma transfusion was lower in group B, p < 0.035. Both the operation time and the hospital stay were also less for group B but without reaching statistical significance (84.6 ± 35.2 vs 101.2 ± 52.45 min. and 5.8 ± 1.6 vs 7.2 ± 3.6 days respectively, p < 0.064). The overall transfusion rate did not differ significantly. No side effects of aprotinin were noted.</p> <p>Conclusion</p> <p>The perioperative ultra-low dose aprotinin administration was associated with a reduction of total blood losses and blood product requirements. We therefore consider the use of aprotinin safe and effective in major thoracic surgery.</p

Identification of Lysine 37 of Histone H2B as a Novel Site of Methylation

Recent technological advancements have allowed for highly-sophisticated mass spectrometry-based studies of the histone code, which predicts that combinations of post-translational modifications (PTMs) on histone proteins result in defined biological outcomes mediated by effector proteins that recognize such marks. While significant progress has been made in the identification and characterization of histone PTMs, a full appreciation of the complexity of the histone code will require a complete understanding of all the modifications that putatively contribute to it. Here, using the top-down mass spectrometry approach for identifying PTMs on full-length histones, we report that lysine 37 of histone H2B is dimethylated in the budding yeast Saccharomyces cerevisiae. By generating a modification-specific antibody and yeast strains that harbor mutations in the putative site of methylation, we provide evidence that this mark exist in vivo. Importantly, we show that this lysine residue is highly conserved through evolution, and provide evidence that this methylation event also occurs in higher eukaryotes. By identifying a novel site of histone methylation, this study adds to our overall understanding of the complex number of histone modifications that contribute to chromatin function

The Toxic Effects of Cigarette Additives. Philip Morris' Project Mix Reconsidered: An Analysis of Documents Released through Litigation

Stanton Glantz and colleagues analyzed previously secret tobacco industry documents and peer-reviewed published results of Philip Morris' Project MIX about research on cigarette additives, and show that this research on the use of cigarette additives cannot be taken at face value