431 research outputs found
Developmental Changes in GABAergic Mechanisms in Human Visual Cortex Across the Lifespan
Functional maturation of visual cortex is linked with dynamic changes in synaptic expression of GABAergic mechanisms. These include setting the excitation–inhibition balance required for experience-dependent plasticity, as well as, intracortical inhibition underlying development and aging of receptive field properties. Animal studies have shown that there is developmental regulation of GABAergic mechanisms in visual cortex. In this study, we show for the first time how these mechanisms develop in the human visual cortex across the lifespan. We used Western blot analysis of postmortem tissue from human primary visual cortex (n = 30, range: 20 days to 80 years) to quantify expression of eight pre- and post-synaptic GABAergic markers. We quantified the inhibitory modulating cannabinoid receptor (CB1), GABA vesicular transporter (VGAT), GABA synthesizing enzymes (GAD65/GAD67), GABAA receptor anchoring protein (Gephyrin), and GABAA receptor subunits (GABAAα1, GABAAα2, GABAAα3). We found a complex pattern of different developmental trajectories, many of which were prolonged and continued well into the teen, young adult, and even older adult years. These included a monotonic increase or decrease (GABAAα1, GABAAα2), a biphasic increase then decrease (GAD65, Gephyrin), or multiple increases and decreases (VGAT, CB1) across the lifespan. Comparing the balances between the pre- and post-synaptic markers we found three main transition stages (early childhood, early teen years, aging) when there were rapid switches in the composition of the GABAergic signaling system, indicating that functioning of the GABAergic system must change as the visual cortex develops and ages. Furthermore, these results provide key information for translating therapies developed in animal models into effective treatments for amblyopia in humans
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Accurately characterising the importance of wave-particle interactions in radiation belt dynamics: the pitfalls of statistical wave representations
Wave-particle interactions play a crucial role in energetic particle dynamics in the Earth's radiation belts. However the relative importance of different wave-modes in these dynamics is poorly understood. Typically this is assessed during geomagnetic storms using statistically averaged empirical wave models as a function of geomagnetic activity in advanced radiation belt simulations. However statistical averages poorly characterise extreme events such as geomagnetic storms in that storm-time ULF wave power is typically larger than that derived over a solar cycle and Kp is a poor proxy for storm-time wave power
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Automated determination of auroral breakup during the substorm expansion phase using all sky imager data
This technique paper describes a novel method for quantitatively and routinely identifying auroral breakup following substorm onset using the Time History of Events and Macroscale Interactions During Substorms (THEMIS) all-sky imagers (ASIs). Substorm onset is characterised by a brightening of the aurora that is followed by auroral poleward expansion and auroral breakup. This breakup can be identified by a sharp increase in the auroral intensity i(t) and the time derivative of auroral intensity i'(t). Utilising both i(t) and i'(t) we have developed an algorithm for identifying the time interval and spatial location of auroral breakup during the substorm expansion phase within the field of view of ASI data based solely on quantifiable characteristics of the optical auroral emissions. We compare the time interval determined by the algorithm to independently identified auroral onset times from three previously published studies. In each case the time interval determined by the algorithm is within error of the onset independently identified by the prior studies. We further show the utility of the algorithm by comparing the breakup intervals determined using the automated algorithm to an independent list of substorm onset times. We demonstrate that up to 50% of the breakup intervals characterised by the algorithm are within the uncertainty of the times identified in the independent list. The quantitative description and routine identification of an interval of auroral brightening during the substorm expansion phase provides a foundation for unbiased statistical analysis of the aurora to probe the physics of the auroral substorm as a new scientific tool for aiding the identification of the processes leading to auroral substorm onset
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Statistical characterisation of the growth and spatial scales of the substorm onset arc
We present the first multi-event study of the spatial and temporal structuring of the aurora to provide statistical evidence of the near-Earth plasma instability which causes the substorm onset arc. Using data from ground-based auroral imagers, we study repeatable signatures of along-arc auroral beads, which are thought to represent the ionospheric projection of magnetospheric instability in the near-Earth plasma sheet. We show that the growth and spatial scales of these wave-like fluctuations are similar across multiple events, indicating that each sudden auroral brightening has a common explanation. We find statistically that growth rates for auroral beads peak at low wavenumber with the most unstable spatial scales mapping to an azimuthal wavelength λ≈1700 − 2500 km in the equatorial magnetosphere at around 9-12 RE. We compare growth rates and spatial scales with a range of theoretical predictions of magnetotail instabilities, including the cross-field current instability and the shear-flow ballooning instability. We conclude that, although the cross-field current instability can generate similar magnitude of growth rates, the range of unstable wavenumbers indicates that the shear-flow ballooning instability is the most likely explanation for our observations
ULF wave derived radiation belt radial diffusion coefficients
Waves in the ultra-low-frequency (ULF) band have frequencies which can be drift
resonant with electrons in the outer radiation belt, suggesting the potential for strong
interactions and enhanced radial diffusion. Previous radial diffusion coefficient models
such as those presented by Brautigam and Albert (2000) have typically used semiempirical
representations for both the ULF wave’s electric and magnetic field power spectral
densities (PSD) in space in the magnetic equatorial plane. In contrast, here we use
ground- and space-based observations of ULF wave power to characterize the electric and
magnetic diffusion coefficients. Expressions for the electric field power spectral
densities are derived from ground-based magnetometer measurements of the magnetic field
PSD, and in situ AMPTE and GOES spacecraft measurements are used to derive
expressions for the compressional magnetic field PSD as functions of Kp, solar wind
speed, and L-shell. Magnetic PSD results measured on the ground are mapped along the
field line to give the electric field PSD in the equatorial plane assuming a guided
Alfvén wave solution and a thin sheet ionosphere. The ULF wave PSDs are then used to
derive a set of new ULF-wave driven diffusion coefficients. These new diffusion
coefficients are compared to estimates of the electric and magnetic field diffusion
coefficients made by Brautigam and Albert (2000) and Brautigam et al. (2005).
Significantly, our results, derived explicitly from ULF wave observations, indicate that
electric field diffusion is much more important than magnetic field diffusion in the
transport and energization of the radiation belt electrons
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A framework for understanding and quantifying the loss and acceleration of relativistic electrons in the outer radiation belt during geomagnetic storms
We present detailed analysis of the global relativistic electron dynamics as measured by total radiation belt content (RBC) during coronal mass ejection (CME) and corotating interaction region (CIR)‐driven geomagnetic storms. Recent work has demonstrated that the response of the outer radiation belt is consistent and repeatable during geomagnetic storms. Here we build on this work to show that radiation belt dynamics can be divided into two sequential phases, which have different solar wind dependencies and which when analyzed separately reveal that the radiation belt responds more predictably than if the overall storm response is analyzed as a whole. In terms of RBC, in every storm we analyzed, a phase dominated by loss is followed by a phase dominated by acceleration. Analysis of the RBC during each of these phases demonstrates that they both respond coherently to solar wind and magnetospheric driving. However, the response is independent of whether the storm response is associated with either a CME or CIR. Our analysis shows that during the initial phase, radiation belt loss is organized by the location of the magnetopause and the strength of Dst and ultralow frequency wave power. During the second phase, radiation belt enhancements are well organized by the amplitude of ultralow frequency waves, the auroral electroject index, and solar wind energy input. Overall, our results demonstrate that storm time dynamics of the RBC is repeatable and well characterized by solar wind and geomagnetic driving, albeit with different dependencies during the two phases of a storm
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How Do Ultra‐Low Frequency Waves Access the Inner Magnetosphere During Geomagnetic Storms?
Wave‐particle interactions play a key role in radiation belt dynamics. Traditionally, ultra‐low frequency (ULF) wave‐particle interaction is parameterized statistically by a small number of controlling factors for given solar wind driving conditions or geomagnetic activity levels. Here we investigate solar wind driving of ULF wave power and the role of the magnetosphere in screening that power from penetrating deep into the inner magnetosphere. We demonstrate that during enhanced ring current intensity, the Alfvén continuum plummets, allowing lower frequency waves to penetrate deeper into the magnetosphere than during quiet periods. With this penetration, ULF wave power is able to accumulate closer to the Earth than characterized by statistical models. During periods of enhanced solar wind driving such as coronal mass ejection driven storms, where ring current intensities maximize, the observed penetration provides a simple physics‐based reason for why storm time ULF wave power is different compared to nonstorm time waves
Do statistical models capture the dynamics of the magnetopause during sudden magnetospheric compressions?
Under periods of strong solar wind driving, the magnetopause can become compressed, playing a significant role in draining electrons from the outer radiation belt. Also termed “magnetopause shadowing,” this loss process has traditionally been attributed to a combination of magnetospheric compression and outward radial diffusion of electrons. However, the drift paths of relativistic electrons and the location of the magnetopause are usually calculated from statistical models and, as such, may not represent the time‐varying nature of this highly dynamic process. In this study, we construct a database ∼20,000 spacecraft crossings of the dayside magnetopause to quantify the accuracy of the commonly used Shue et al. (1998, https://doi.org/10.1029/98JA01103) model. We find that, for the majority of events (74%), the magnetopause model can be used to estimate magnetopause location to within ±1 RE. However, if the magnetopause is compressed below 8 RE, the observed magnetopause is greater than 1 RE inside of the model location on average. The observed magnetopause is also significantly displaced from the model location during storm sudden commencements, when measurements are on average 6% closer to the radiation belts, with a maximum of 42%. We find that the magnetopause is rarely close enough to the outer radiation belt to cause direct magnetopause shadowing, and hence rapid outward radial transport of electrons is also required. We conclude that statistical magnetopause parameterizations may not be appropriate during dynamic compressions. We suggest that statistical models should only be used during quiescent solar wind conditions and supplemented by magnetopause observations wherever possible
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Reply to comment by K. Liou and Y.-L. Zhang on 'Wavelet-based ULF wave diagnosis of substorm expansion phase onset'
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