A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation

Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (31570033 to Y. Y.) and the Leverhulme Trust-Royal Society Africa Award (AA090088 to K. K and H. D.). Open access via RSC Gold 4 Gold.Peer reviewedPublisher PD

Discovery of New Antibacterial Accramycins from a Genetic Variant of the Soil Bacterium, Streptomyces sp. MA37

Funding: F.M. is thankful to the University of the Philippines Faculty, Reps, and Staff Development Program (FRAS DP) for funding the doctoral studies. H.D. and K.K. are grateful for the financial support of the Leverhulme Trust-Royal Society Africa award (AA090088) and the jointly funded UK Medical Research Council–UK Department for International Development (MRC/DFID) Concordat Agreement African Research Leaders Award (MR/S00520X/1). Supplementary Materials: The following are available online at http://www.mdpi.com/2218-273X/10/10/1464/s1.Peer reviewedPublisher PD

Effective Detection, Isolation and Characterization of Dakaramine from Ghanaian Axinella sp and Bioactivity

Abstract The Ghanaian sponge Axinella sp collected for the first time from the Gulf of Guinea yielded similar amounts of dakaramine (1), acetamide and a new hydroxylated acetate metabolite (2). The structures of these metabolites were elucidated by 1D and 2D NMR data interpretation. The halogens in dakaramine were detected by high performance liquid chromatography coupled with inductively coupled plasma and electrospray ionization mass spectrometry (HPLC-ICPMS/ESMS), a technique that allows for heteroatoms and metals in organic compounds to be detected specifically and with very high sensitivity. Cytotoxicity of dakaramine was assessed in vitro using two human cancer cell lines, human lymphocytic cell (Jurkat) and acute promyelocytic leukemia (HL60). This compound was found to be acutely toxic to these cell lines with IC50 values of 35.0 and 26.5 µg/ml respectively

Identification of 5-Fluoro-5-Deoxy-Ribulose as a Shunt Fluorometabolite in Streptomyces sp. MA37

Funding: This study was funded by an IBioIC PhD studentship (L.W.), a Leverhulme Trust Research Project (H.D. and M.H.T., project no. RPG-2014-418), a Leverhulme Trust–Royal Society Africa award (K.K. and H.D., AA090088), the jointly funded UK Medical Research Council–UK Department for International Development (MRC/DFID) concordat agreement African Research Leaders Award (K.K. and H.D., MR/S00520X/1), and the Royal Society–NSFC Newton Mobility Grant Award (IEC\NSFC\170617 to H.D.).Peer reviewedPublisher PD

Chemoenzymatic Synthesis of Indole-Containing Acyloin Derivatives

Funding Information: The research was funded by the College of Science and Arts, Jouf University, King Khaled Road, Kingdom of Saudi Arabia, and the Royal Embassy of Saudi Arabia Cultural Bureau in the UK for the PhD scholarship (S.A.); the PhD studentship funded by IBioIC (F.C.), thank the financial supports of Leverhulme Trust-Royal Society Africa award (AA090088) and the jointly funded UK Medical Research Council UK Department for International Development (MRC/DFID) Concordat agreement African Research Leaders Award (MR/S00520X/1) (H.D. and K.K.).Peer reviewedPublisher PD

Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310

Peer reviewedPublisher PD

Targeted isolation of indole alkaloids from Streptomyces sp. CT37

Q.F. is grateful to the University of Aberdeen Elphinstone Scholarship and Scottish Funding Council/ScotCHEM for financial support through the PEER/PERCE Funding. F.M. thanks the University of the Philippines for the Faculty, Reps, and Staff Development Program (FRAS DP) for the PhD grant fellowship. H.D. and K.K. thank the financial supports of Leverhulme Trust-Royal Society Africa award (AA090088) and the jointly funded UK Medical Research Council-UK Department for InternationalmDevelopment (MRC/DFID) Concordat agreement African Research Leaders Award (MR/S00520X/1).Peer reviewedPublisher PD

Draft Genome Sequence of Streptomyces sp. Strain CT34, Isolated from a Ghanaian Soil Sample

Copyright © 2015 Zhai et al. This work was supported by the China “973” program (2012CB721001), the “863” Program (2012AA092201), the National Natural Science Foundation of China (31170467), and the EU FP7 project PharmaSea (312184). K.K., M.J., and H.D. thank the Royal Society–Leverhulme Trust Africa for the financial support (award AA090088) that enabled the sampling of sediments and subsequent isolation of this unique Ghanaian strain.Non peer reviewedPublisher PD

A Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metabolite

FM thanks the University of the Philippines Faculty, Reps, and Staff Development Program (FRASDP) for the PhD grant fellowship. HD and KK are grateful for the financial support of the Leverhulme Trust‐Royal Society Africa award (AA090088) and the jointly funded UK Medical Research Council–UK Department for International Development (MRC/DFID) Concordat Agreement African Research Leaders Award (MR/S00520X/1). RE is grateful to British Council/Newton Fund for financial support through the Institutional Links scheme (Project No. 261781172). QF is grateful to the University of Aberdeen Elphinstone Scholarship and the Scottish Funding Council/ScotCHEM for financial support through PEER/PERCE FundingPeer reviewedPublisher PD

Accramycin A, a New Aromatic Polyketide, from the Soil Bacterium, Streptomyces sp. MA37

Funding: FM thanks the University of the Philippines for the Faculty, Reps and Staff Development Program (FRAS DP) for the PhD grant fellowship. HD and KK thank the financial supports of Leverhulme Trust-Royal Society Africa award (AA090088) and MRC African Research Leaders Award (MR/S00520X/1). R.E. and S.S. are grateful to British Council/Newton Fund for financial support through the Institutional Links scheme (Project No. 261781172). QF is grateful to the University of Aberdeen Elphinstone Scholarship and Scottish Funding Council/ScotCHEM for financial support through the PEER/PERCE Funding.Peer reviewedPublisher PD