Parameter-Free Algorithms for Performative Regret Minimization under Decision-Dependent Distributions

This paper studies performative risk minimization, a formulation of stochastic optimization under decision-dependent distributions. We consider the general case where the performative risk can be non-convex, for which we develop efficient parameter-free optimistic optimization-based methods. Our algorithms significantly improve upon the existing Lipschitz bandit-based method in many aspects. In particular, our framework does not require knowledge about the sensitivity parameter of the distribution map and the Lipshitz constant of the loss function. This makes our framework practically favorable, together with the efficient optimistic optimization-based tree-search mechanism. We provide experimental results that demonstrate the numerical superiority of our algorithms over the existing method and other black-box optimistic optimization methods

Proceedings of IMECE2008

ABSTRACT Several healthcare products have been developed and marketed in recent times as a result of people's growing interest in personal health. Unstable shoes have been introduced to revitalize the muscles of the lower limbs and to modify the gait posture while walking. However, healthcare products for people should first be proved functional and safe, as some of those can sometimes result in severe injuries and side effects. Certification is, therefore, necessary in the case of unstable shoes. In this study, the functionality of unstable shoes was analyzed; it was proved that difference in pressure distribution resulting from the shape of the unstable shoes helps strengthen the muscles of the lower limbs. These analyses focused on the activation of the muscles by employing EMG (Electromyography). However, the approach involving EMG cannot carry out measurements on hidden muscles, and the noise involved is a source of potential error; therefore, this study utilizes the simulation software SIMM (Software for Interactive Musculoskeletal Modeling) for this purpose. We performed a biomechanical study using a full-body musculoskeletal model. Using the captured 3D motion data and ground reaction forces data, kinetic data was calculated in order to determine its influence on the adjacent segments. We captured the movements of six volunteers, all males in their twenties. The volunteers wore both unstable and normal shoes during each trial. This study focuses on the activation of muscles of the lower limbs when wearing unstable shoes. We inspected the muscles and analyzed the disparities between unstable and normal shoes. We observed from experimental results that most muscles of the lower limbs were revitalized. Further, we observed an improvement in the gait posture after unstable shoes were used for a period of 12 weeks. This analysis of inner muscles that cannot be examined by direct methods can help consumers make informed choices regarding healthcare products. Such analysis is made possible by simulation programs such as SIMM

Cellular direct conversion by cell penetrable OCT4-30Kc19 protein and BMP4 growth factor

Background : The number of patients suffering from osteoporosis is increasing as the elderly population increases. The demand for investigating bone regeneration strategies naturally arises. One of the approaches to induce bone regeneration is somatic cell transdifferentiation. Among the transcriptional regulators for transdifferentiation, octamer-binding transcription factor 4 (OCT4) is famous for its role in the regulation of pluripotency of stem cells. Bone morphogenetic protein 4 (BMP4) is another factor that is known to have a significant role in osteogenic differentiation. Previous studies have achieved transdifferentiation of cells into osteoblasts using viral and plasmid deliveries of these factors. Although these methods are efficient, viral and plasmid transfection have safety issues such as permanent gene incorporations and bacterial DNA insertions. Herein, we developed a cell penetrating protein-based strategy to induce transdifferentiation of endothelial cells into osteoblasts via nuclear delivery of OCT4 recombinant protein combined with the BMP4 treatment. For the nuclear delivery of OCT4 protein, we fused the protein with 30Kc19, a cell-penetrating and protein stabilizing protein derived from a silkworm hemolymph of Bombyx mori with low cytotoxic properties. This study proposes a promising cell-based therapy without any safety issues that existing transdifferentiation approaches had. Methods : OCT4-30Kc19 protein with high penetrating activities and stability was synthesized for a protein-based osteogenic transdifferentiation system. Cells were treated with OCT4-30Kc19 and BMP4 to evaluate their cellular penetrating activity, cytotoxicity, osteogenic and angiogenic potentials in vitro. The osteogenic potential of 3D cell spheroids was also analyzed. In addition, in vivo cell delivery into subcutaneous tissue and cranial defect model was performed. Results : OCT4-30Kc19 protein was produced in a soluble and stable form. OCT4-30Kc19 efficiently penetrated cells and were localized in intracellular compartments and the nucleus. Cells delivered with OCT4-30Kc19 protein combined with BMP4 showed increased osteogenesis, both in 2D and 3D culture, and showed increased angiogenesis capacity in vitro. Results from in vivo subcutaneous tissue delivery of cell-seeded scaffolds confirmed enhanced osteogenic properties of transdifferentiated HUVECs via treatment with both OCT4-30Kc19 and BMP4. In addition, in vivo mouse cranial defect experiment demonstrated successful bone regeneration of HUVECs pretreated with both OCT4-30Kc19 and BMP4. Conclusions : Using a protein-based transdifferentiation method allows an alternative approach without utilizing any genetic modification strategies, thus providing a possibility for safer use of cell-based therapies in clinical applications.This work was fnancially supported by the Ministry of Science and ICT (NRF2021R1A2C2008821). The Institute of Engineering Research at Seoul National University provided research facilities for this work

Search for the Sagittarius Tidal Stream of Axion Dark Matter around 4.55 μ\mueV

We report the first search for the Sagittarius tidal stream of axion dark matter around 4.55 $\mu$eV using CAPP-12TB haloscope data acquired in March of 2022. Our result excluded the Sagittarius tidal stream of Dine-Fischler-Srednicki-Zhitnitskii and Kim-Shifman-Vainshtein-Zakharov axion dark matter densities of $\rho_a\gtrsim0.184$ and $\gtrsim0.025$ GeV/cm$^{3}$, respectively, over a mass range from 4.51 to 4.59 $\mu$eV at a 90% confidence level.Comment: 6 pages, 7 Figures, PRD Letter accepte

Extensive search for axion dark matter over 1\,GHz with CAPP's Main Axion eXperiment

We report an extensive high-sensitivity search for axion dark matter above 1\,GHz at the Center for Axion and Precision Physics Research (CAPP). The cavity resonant search, exploiting the coupling between axions and photons, explored the frequency (mass) range of 1.025\,GHz (4.24\,$\mu$eV) to 1.185\,GHz (4.91\,$\mu$eV). We have introduced a number of innovations in this field, demonstrating the practical approach of optimizing all the relevant parameters of axion haloscopes, extending presently available technology. The CAPP 12\,T magnet with an aperture of 320\,mm made of Nb$_3$Sn and NbTi superconductors surrounding a 37-liter ultralight-weight copper cavity is expected to convert DFSZ axions into approximately $10^2$ microwave photons per second. A powerful dilution refrigerator, capable of keeping the core system below 40\,mK, combined with quantum-noise limited readout electronics, achieved a total system noise of about 200\,mK or below, which corresponds to a background of roughly $4\times 10^3$ photons per second within the axion bandwidth. The combination of all those improvements provides unprecedented search performance, imposing the most stringent exclusion limits on axion--photon coupling in this frequency range to date. These results also suggest an experimental capability suitable for highly-sensitive searches for axion dark matter above 1\,GHz.Comment: A detailed axion dark matter article with 27 pages, 22 figure