Predicting wind turbine blade loads using vorticity transport and RANS methodologies

Two computational methods, one based on the solution of the vorticity transport equation, and a second based on the solution of the Reynolds-Averaged Navier-Stokes equations, have been used to simulate the aerodynamic performance of a horizontal axis wind turbine. Comparisons have been made against data obtained during Phase VI of the NREL Unsteady Aerodynamics Experimental and against existing numerical data for a range of wind conditions. The Reynolds-Averaged Navier-Stokes method demonstrates the potential to predict accurately the flow around the blades and the distribution of aerodynamic loads developed on them. The Vorticity Transport Model possesses a considerable advantage in those situtations where the accurate, but computationally efficient, modelling of the structure of the wake and the associated induced velocity is critical, but where the prediction of blade loads can be achieved with sufficient accuracy using a lifting-line model augmented by incorporating a semi-empirical stall delay model. The largest benefits can be extracted when the two methods are used to complement each other in order to understand better the physical mechanisms governing the aerodynamic performance of wind turbines

Interpreting Labor Supply Regressions in a Model of Full and Part-Time Work

We construct a family model of labor supply that features adjustment along both the intensive and extensive margin. Intensive margin adjustment is restricted to two values: full time work and part-time work. Using simulated data from the steady state of the calibrated model, we examine whether standard labor supply regressions can uncover the true value of the intertemporal elasticity of labor supply parameter. We find positive estimated elasticities that are larger for women and that are highly significant, but they bear virtually no relationship to the underlying preference parameters.

Development and application of a self-referencing glucose microsensor for the measurement of glucose consumption by pancreatic ?-cells

Glucose gradients generated by an artificial source and ?-cells were measured using an enzyme-based glucose microsensor, 8-?m tip diameter, as a self-referencing electrode. The technique is based on a difference measurement between two locations in a gradient and thus allows us to obtain real-time flux values with minimal impact of sensor drift or noise. Flux values were derived by incorporation of the measured differential current into Fick's first equation. In an artificial glucose gradient, a flux detection limit of 8.2 ± 0.4 pmol·cm-2·s-1 (mean ± SEM, n = 7) with a sensor sensitivity of 7.0 ± 0.4 pA/mM (mean ± SEM, n = 16) was demonstrated. Under biological conditions, the glucose sensor showed no oxygen dependence with 5 mM glucose in the bulk medium. The addition of catalase to the bulk medium was shown to ameliorate surface-dependent flux distortion close to specimens, suggesting an underlying local accumulation of hydrogen peroxide. Glucose flux from ?-cell clusters, measured in the presence of 5 mM glucose, was 61.7 ± 9.5 fmol·nL-1·s-1 (mean ± SEM, n = 9) and could be pharmacologically modulated. Glucose consumption in response to FCCP (1 ?M) transiently increased, subsequently decreasing to below basal by 93 ± 16 and 56 ± 6%, respectively (mean ± SEM, n = 5). Consumption was decreased after the application of 10 ?M rotenone by 74 ± 5% (mean ± SEM, n = 4). These results demonstrate that an enzyme-based amperometric microsensor can be applied in the self-referencing mode. Further, in obtaining glucose flux measurements from small clusters of cells, these are the first recordings of the real-time dynamic of glucose movements in a biological microenvironment. <br/

Evaluating the Diversity of Emergency Medicine Foundation (EMF) Grant Recipients in the Last Decade

On behalf of the ACEP Research CommitteeIntroduction: To study diversity of researchers and barriers to success among Emergency Medicine Foundation (EMF) grant recipients in the last 10 years.Methods: EMF grant awardees were approached to complete a brief survey, which included demographics, queries related to contributions to the literature, success in obtaining grants, and any perceived barriers they encountered.Results: Of the 342 researchers contacted by email, a total of 147 completed the survey for a response rate of 43%. The respondents were predominately mid to late career white-male-heterosexual-Christian with an average age of 44 years (range 25-69 years of age). With regards to training and education, the majority of respondents (50%) were either Associate or Professor clinical rank (8% instructor/resident/fellow and 31% Assistant). Sixty-two percent of the respondents reported perceived barriers to career advancement since completion of residency. The largest perceived barrier to success was medical specialty (26%), followed by gender (21%) and age (16%).Conclusion: Our survey of EMF grant recipients in the last 10 years shows a considerable lack of diversity. The most commonly perceived barriers to career advancement by this cohort were medical specialty, gender, and age. An opportunity exists for further definition of barriers and development of mechanisms to overcome them, with a goal of increased success for those that are underrepresented. 

Two Bipolar Outflows and Magnetic Fields in a Multiple Protostar System, L1448 IRS 3

We performed spectral line observations of CO J=2-1, 13CO J=1-0, and C18O J=1-0 and polarimetric observations in the 1.3 mm continuum and CO J=2-1 toward a multiple protostar system, L1448 IRS 3, in the Perseus molecular complex at a distance of ~250 pc, using the BIMA array. In the 1.3 mm continuum, two sources (IRS 3A and 3B) were clearly detected with estimated envelope masses of 0.21 and 1.15 solar masses, and one source (IRS 3C) was marginally detected with an upper mass limit of 0.03 solar masses. In CO J=2-1, we revealed two outflows originating from IRS 3A and 3B. The masses, mean number densities, momentums, and kinetic energies of outflow lobes were estimated. Based on those estimates and outflow features, we concluded that the two outflows are interacting and that the IRS 3A outflow is nearly perpendicular to the line of sight. In addition, we estimated the velocity, inclination, and opening of the IRS 3B outflow using Bayesian statistics. When the opening angle is ~20 arcdeg, we constrain the velocity to ~45 km/s and the inclination angle to ~57 arcdeg. Linear polarization was detected in both the 1.3 mm continuum and CO J=2-1. The linear polarization in the continuum shows a magnetic field at the central source (IRS 3B) perpendicular to the outflow direction, and the linear polarization in the CO J=2-1 was detected in the outflow regions, parallel or perpendicular to the outflow direction. Moreover, we comprehensively discuss whether the binary system of IRS 3A and 3B is gravitationally bound, based on the velocity differences detected in 13CO J=1-0 and C18O J=1-0 observations and on the outflow features. The specific angular momentum of the system was estimated as ~3e20 cm^2/s, comparable to the values obtained from previous studies on binaries and molecular clouds in Taurus.Comment: ApJ accepted, 20 pages, 2 tables, 10 figure

Improved costs and outcomes with conscious sedation vs general anesthesia in TAVR patients: Time to wake up?

BackgroundTranscatheter aortic valve replacement (TAVR) has become a commonplace procedure for the treatment of aortic stenosis in higher risk surgical patients. With the high cost and steadily increasing number of patients receiving TAVR, emphasis has been placed on optimizing outcomes as well as resource utilization. Recently, studies have demonstrated the feasibility of conscious sedation in lieu of general anesthesia for TAVR. This study aimed to investigate the clinical as well as cost outcomes associated with conscious sedation in comparison to general anesthesia in TAVR.MethodsRecords for all adult patients undergoing TAVR at our institution between August 2012 and June 2016 were included using our institutional Society of Thoracic Surgeons (STS) and American College of Cardiology (ACC) registries. Cost data was gathered using the BIOME database. Patients were stratified into two groups according to whether they received general anesthesia (GA) or conscious sedation (CS) during the procedure. No-replacement propensity score matching was done using the validated STS predicted risk of mortality (PROM) as a propensity score. Primary outcome measure with survival to discharge and several secondary outcome measures were also included in analysis. According to our institution's data reporting guidelines, all cost data is presented as a percentage of the general anesthesia control group cost.ResultsOf the 231 patients initially identified, 225 (157 GA, 68 CS) were included for analysis. After no-replacement propensity score matching, 196 patients (147 GA, 49 CS) remained. Overall mortality was 1.5% in the matched population with a trend towards lower mortality in the CS group. Conscious sedation was associated with significantly fewer ICU hours (30 vs 96 hours, p = &lt;0.001) and total hospital days (4.9 vs 10.4, p&lt;0.001). Additionally, there was a 28% decrease in direct cost (p&lt;0.001) as well as significant decreases in all individual all cost categories associated with the use of conscious sedation. There was no difference in composite major adverse events between groups. These trends remained on all subsequent subgroup analyses.ConclusionConscious sedation is emerging as a safe and viable option for anesthesia in patients undergoing transcatheter aortic valve replacement. The use of conscious sedation was not only associated with similar rates of adverse events, but also shortened ICU and overall hospital stays. Finally, there were significant decreases in all cost categories when compared to a propensity matched cohort receiving general anesthesia