Enhanced antigen presentation and immunostimulation of dendritic cells using acid-degradable cationic nanoparticles.

Acid-degradable cationic nanoparticles encapsulating a model antigen (i.e., ovalbumin) were prepared by inverse microemulsion polymerization with acid-cleavable acetal cross-linkers. Incubation of these degradable nanoparticles with dendritic cells derived from bone marrow (BMDCs) resulted in the enhanced presentation of ovalbumin-derived peptides, as quantified by B3Z cells, a CD8+ T cell hybridoma. The cationic nature of the particles contributed to the increased surface endocytosis (or phagocytosis) observed with BMDCs, which is the first barrier to overcome for successful antigen delivery. The acid sensitivity of the particles served to direct more ovalbumin antigens to be processed into the appropriately trimmed peptide fragments and presented via the major histocompatibility complex (MHC) class I pathway following hydrolysis within the acidic lysosomes. It was also shown that adjuvant molecules such as unmethylated CpG oligonucleotides (CpG ODN) and anti-interleukin-10 oligonucleotides (AS10 ODN) could be co-delivered with the protein antigen for maximized cellular immune response

Orientational Melting in Carbon Nanotube Ropes

Using Monte Carlo simulations, we investigate the possibility of an orientational melting transition within a "rope" of (10,10) carbon nanotubes. When twisting nanotubes bundle up during the synthesis, orientational dislocations or twistons arise from the competition between the anisotropic inter-tube interactions, which tend to align neighboring tubes, and the torsion rigidity that tends to keep individual tubes straight. We map the energetics of a rope containing twistons onto a lattice gas model and find that the onset of a free "diffusion" of twistons, corresponding to orientational melting, occurs at T_OM > 160 K.Comment: 4 page LaTeX file with 3 figures (10 PostScript files

EVALUATING A PRECISION AGRICULTURE HERBICIDE DECISION MODEL FOR WINTER WHEAT

Replaced with revised version of paper 08/02.Crop Production/Industries,

Structure And Properties of Nanoparticles Formed under Conditions of Wire Electrical Explosion

Structure and properties of nanoparticles formed under conditions of wire electrical explosion were studied. It was shown that the state of WEE power particles can be characterized as a metastable state. It leads to an increased stability of nanopowders at normal temperatures and an increased reactivity during heating, which is revealed in the form of threshold phenomena.Comment: Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions

Simulation of iced wing aerodynamics

The sectional and total aerodynamic load characteristics of moderate aspect ratio wings with and without simulated glaze leading edge ice were studied both computationally, using a three dimensional, compressible Navier-Stokes solver, and experimentally. The wing has an untwisted, untapered planform shape with NACA 0012 airfoil section. The wing has an unswept and swept configuration with aspect ratios of 4.06 and 5.0. Comparisons of computed surface pressures and sectional loads with experimental data for identical configurations are given. The abrupt decrease in stall angle of attack for the wing, as a result of the leading edge ice formation, was demonstrated numerically and experimentally

Electronic structures of doped anatase TiO2\rm TiO_{2}: Ti1−xMxO2\rm Ti_{1-x}M_{x}O_{2} (M=Co, Mn, Fe, Ni)

We have investigated electronic structures of a room temperature diluted magnetic semiconductor : Co-doped anatase $\rm TiO_{2}$. We have obtained the half-metallic ground state in the local-spin-density approximation(LSDA) but the insulating ground state in the LSDA+$U$+SO incorporating the spin-orbit interaction. In the stoichiometric case, the low spin state of Co is realized with the substantially large orbital moment. However, in the presence of oxygen vacancies near Co, the spin state of Co becomes intermediate. The ferromagnetisms in the metallic and insulating phases are accounted for by the double-exchange-like and the superexchange mechanism, respectively. Further, the magnetic ground states are obtained for Mn and Fe doped $\rm TiO_{2}$, while the paramagnetic ground state for Ni-doped $\rm TiO_{2}$.Comment: 5 pages, 4 figure

Who Contributes to the Knowledge Sharing Economy?

Information sharing dynamics of social networks rely on a small set of influencers to effectively reach a large audience. Our recent results and observations demonstrate that the shape and identity of this elite, especially those contributing \emph{original} content, is difficult to predict. Information acquisition is often cited as an example of a public good. However, this emerging and powerful theory has yet to provably offer qualitative insights on how specialization of users into active and passive participants occurs. This paper bridges, for the first time, the theory of public goods and the analysis of diffusion in social media. We introduce a non-linear model of \emph{perishable} public goods, leveraging new observations about sharing of media sources. The primary contribution of this work is to show that \emph{shelf time}, which characterizes the rate at which content get renewed, is a critical factor in audience participation. Our model proves a fundamental \emph{dichotomy} in information diffusion: While short-lived content has simple and predictable diffusion, long-lived content has complex specialization. This occurs even when all information seekers are \emph{ex ante} identical and could be a contributing factor to the difficulty of predicting social network participation and evolution.Comment: 15 pages in ACM Conference on Online Social Networks 201

“See, Click, Fix”: Civic Interrogation and Digital Tools in a Ninth-Grade Ethnic Studies Course

Drawing from the theoretical contributions of Ethnic Studies, activist new media, and critical digital literacies, this article explores the nature of a ninth-grade curricular unit about how one’s daily environment impacts one’s health and well-being. Using a combination of ethnographic and practitioner inquiry methods, the authors highlight an Ethnic Studies teacher’s innovative and community-based pedagogy that honed students’ critical digital literacies and civic action practices through their engagement with the digital media app “See, Click, Fix.” Findings detail students’ perspectives about how the unit both helped them resist deficit-oriented ideologies and served as a conduit for critical civic literacies. The authors contend that the fostering of critical digital literacies remain extremely imperative to the future and expansion of Ethnic Studies courses