data set

data se

Causes of systemic inflammation.

<p>Causes of systemic inflammation.</p

Demographic and clinical profiles of cases and controls.

<p>Demographic and clinical profiles of cases and controls.</p

Multivariate models of effect of baseline CRP on change in UPDRS-III score for the final follow-up period (Days 631–900), as estimated by a generalized linear model.

<p>Multivariate models of effect of baseline CRP on change in UPDRS-III score for the final follow-up period (Days 631–900), as estimated by a generalized linear model.</p

Changes in Unified Parkinson’s Disease Rating Scale Part III (UPDRS-III) scores (A) and L-dopa equivalent dose (LED) (B) by tertile of baseline C-reactive protein (CRP) concentrations.

<p>UPDRS-III score and LED (mg/day) were measured at the study enrollment and during the follow-up period. Subjects were sorted by baseline CRP concentration [≤0.2 mg/L (blue), 0.3–0.6 mg/L (green), and ≥0.7 mg/L (red)]. Symbols, and upper and lower error bars represent mean and 95% CI, respectively.</p

Relevant clinical and other variables of study participants.

<p>Relevant clinical and other variables of study participants.</p

PDVFS.

<p>PDVFS.</p

Flow diagram of participants included in the study.

<p>Flow diagram of participants included in the study.</p

Multivariate models of effect of baseline C-reactive protein (CRP) on change in Unified Parkinson’s Disease Rating Scale Part III (UPDRS-III) score for the entire follow-up period, as estimated by a generalized estimation equation model.

<p>Multivariate models of effect of baseline C-reactive protein (CRP) on change in Unified Parkinson’s Disease Rating Scale Part III (UPDRS-III) score for the entire follow-up period, as estimated by a generalized estimation equation model.</p

Relative risk of death by CRP concentration.

<p>Relative risk of death was estimated as hazard ratios (HRs) using Cox proportional hazard models. Unadjusted HRs of all deaths correlated with log CRP concentrations (A). To exclude possible confounders, HRs of all deaths were adjusted for age, sex, PD disease duration, MMSE (≤24 <i>vs</i>. >24), mH-Y (1–3 <i>vs</i>. 4–5), and serum albumin levels, and the analysis showed a log-linear association with CRP concentrations (B). Similarly unadjusted and adjusted HRs of death, excluding PD-unrelated deaths, correlated with CRP concentrations (C, D). Unadjusted and age- and sex-adjusted HRs of deaths from pneumonia correlated with CRP concentrations (E, F). Unadjusted and age- and sex-adjusted HRs of sudden deaths correlated with CRP concentrations, although there was no significance (G, H). Unadjusted and age- and sex-adjusted HRs of deaths from cancer correlated with CRP concentration, although there was no significance (I, J).</p