155 research outputs found
Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore
Background Few studies have investigated physical activity (PA) and sedentary
behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose
(2hPG) levels and gestational diabetes mellitus (GDM); we investigated these
associations among Asian pregnant women. Methods As part of the Growing Up in
Singapore Towards healthy Outcomes cohort study, PA and SB (sitting and
television times) were assessed by interviewer-administered questionnaire.
During 75 g oral glucose tolerance tests at 26–28 weeks’ gestation we measured
FG, 2hPG levels and GDM (FG ≥ 7.0 mmol/L and/or 2hPG ≥ 7.8 mmol/L).
Associations were analysed by multiple linear and logistic regression. Results
Among the 1083 women studied, 18.6% had GDM. SB was not associated with FG,
2hPG and GDM. Higher categories of PA were associated with lower 2hPG and a
lower likelihood of GDM (p-trend < 0.05), but not with FG levels. Compared to
insufficiently active women, highly active women had lower 2hPG levels [β (95%
CI): -0.32 (−0.59, −0.05), p = 0.020) and were less likely to have GDM [OR:
0.56 (0.32–0.98), p = 0.040]. Stratified analysis revealed no associations
among under/normal-weight women, but significant associations among
overweight/obese women; in those with BMI ≥23 kg/m2, sufficiently active and
highly active women were less likely to have GDM [OR: 0.52, (0.29–0.93), p =
0.028, and OR: 0.34, (0.15–0.77), p = 0.010, respectively]. Conclusion Higher
PA was associated with lower 2hPG levels and a lower prevalence of GDM,
particularly in overweight/obese women. Further studies are warranted to
confirm these findings, and to examine the effectiveness of PA promotion
strategies for the prevention of gestational hyperglycemia
Developmental synchrony of thalamocortical circuits in the neonatal brain
10.1016/j.neuroimage.2015.03.039Neuroimage116168-176GUSTO (Growing up towards Healthy Outcomes
A healthy eating index to measure diet quality in pregnant women in Singapore: a cross-sectional study
10.1186/s40795-015-0029-3BMC Nutrition1391-11GUSTO (Growing up towards Healthy Outcomes
Eye size and shape in newborn children and their relation to axial length and refraction at 3 years
10.1111/opo.12212Ophthalmic and Physiological Optics354414-423GUSTO (Growing up towards Healthy Outcomes
Unconditional and conditional standards for fetal abdominal circumference and estimated fetal weight in an ethnic Chinese population: a birth cohort study
10.1186/s12884-015-0569-1BMC Pregnancy and Childbirth151411-11GUSTO (Growing up towards Healthy Outcomes
Inflammatory Aetiology of Human Myometrial Activation Tested Using Directed Graphs
There are three main hypotheses for the activation of the human uterus at labour: functional progesterone withdrawal, inflammatory stimulation, and oxytocin receptor activation. To test these alternatives we have taken information and data from the literature to develop causal pathway models for the activation of human myometrium. The data provided quantitative RT-PCR results on key genes from samples taken before and during labour. Principal component analysis showed that pre-labour samples form a homogenous group compared to those during labour. We therefore modelled the alternative causal pathways in non-labouring samples using directed graphs and statistically compared the likelihood of the different models using structural equations and D-separation approaches. Using the computer program LISREL, inflammatory activation as a primary event was highly consistent with the data (p = 0.925), progesterone withdrawal, as a primary event, is plausible (p = 0.499), yet comparatively unlikely, oxytocin receptor mediated initiation is less compatible with the data (p = 0.091). DGraph, a software program that creates directed graphs, produced similar results (p = 0.684, p = 0.280, and p = 0.04, respectively). This outcome supports an inflammatory aetiology for human labour. Our results demonstrate the value of directed graphs in determining the likelihood of causal relationships in biology in situations where experiments are not possible
Incremental cost-effectiveness analysis of gestational diabetes mellitus screening strategies in Singapore
10.1177/1010539515612908Asia-Pacific Journal of Public Health28115-25GUSTO (Growing up towards Healthy Outcomes
Infant feeding practices in a multi-ethnic Asian cohort: the GUSTO study
10.3390/nu8050293Nutrients851-17GUSTO (Growing up towards Healthy Outcomes
Maternal blood pressure during pregnancy and early childhood blood pressures in the offspring
10.1097/MD.0000000000001981Medicine94451-9GUSTO (Growing up towards Healthy Outcomes
Ethnic differences in effects of maternal prepregnancy and pregnancy adiposity on offspring size and adiposity
10.1210/jc.2015-1728The Journal of Clinical Endocrinology & Metabolism100103641–3650GUSTO (Growing up towards Healthy Outcomes
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