Thinking the Future - The Branch Library of Medicine of the Saxon State and University Library of Dresden plans a new building

The Branch Library of Medicine of the Saxon State and University Library of Dresden (SLUB) plans a new building opening effective future prospects - best place for learning and communication on medical campus in Dresden-Johannstadt and a location factor for scientific information providing at the University Hospital and Faculty of Medicine of the Dresden University of Technology too. The paper explains the intention of the plan and, in addition, introduces the present performed library services.Die Zweigbibliothek Medizin der Sächsischen Landesbibliothek - Staats- und Universitätsbibliothek Dresden (SLUB) plant einen Neubau, der ihr nachhaltige Entwicklungsperspektiven als Ort des Lernens und der Kommunikation auf dem Medizincampus in Dresden-Johannstadt wie auch als Standortfaktor für wissenschaftliche Informationsvermittlung im Universitätsklinikum und in der Medizinischen Fakultät der Technischen Universität Dresden eröffnet. Der Beitrag erläutert die Konzeption des Vorhabens und stellt darüber hinaus das heutige Leistungsspektrum der Bibliothek vor

The effects of Nrf2 deletion on placental morphology and exchange capacity in the mouse

Objectives: Intrauterine growth restriction (IUGR) is defined as a pathological decreased fetal growth. Oxidative stress has been connected to the restriction in the fetal growth. The transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) is a potent activator of the cellular antioxidant response. The effect Nrf2 on fetal–placental development has not yet been sufficiently investigated. Here, we evaluated the placental and fetal growth in Nrf2 knockout (Nrf2-KO) and Nrf2-wild type mice (Nrf2-WT) throughout pregnancy. Methods: Heterozygote Nrf2 (Nrf2+/−) mice were paired to get Nrf2-KO and Nrf2-WT in the litters. Placentae and embryos from both genotypes were collected and weighed on days 13.5, 15.5 and 18.5 post coitum. The absolute volumes of the labyrinth zone and the total volume of the placenta were determined using the Cavalieri principle. Results: On E 18.5 the fetal weight in Nrf2-KO was significantly reduced versus Nrf2-WT indicating a decrease in placental efficiency. A significant reduction in both total and labyrinth-volume in the placenta of Nrf2-KO mice was observed. Conclusion: This data points out the necessity of functional Nrf2 for fetal and placental growth. A deficiency in Nrf2 signaling may negatively affect nutrient transfer capacity which is then no longer able to meet fetal growth demands