Modeling the Demand for food Safety and the Implications for Regulation

The modern theory of demand which underlies much of economic analysis of consumer behavior is based on the premise that consumption goods are pure and do not involve risks. However, that is clearly not the case where concerns about food safety are involved. The awareness of linkages between consumption of foods and adverse health effects indicates the need for a new framework for investigating demand for food and food safety, and for guiding the appropriate government response to achieve optimal regulation of food safety levels. We develop such a framework and show that when safety is endogenous to the consumer\u27s decision over a consumption bundle, perfect safety is not optimal. There are several implications of the model. Empirical analysis based on conventional demand theory may lack predictive power due to model misspecification and the unobserved survival probability function. Furthermore, if markets are perfectly competitive and consumers accurately informed about safety risk, there is no need for government regulation. However, when markets are not perfectly competitive, and answer is less clear-cut. And, risk differentiation may become a new basis for acquiring and exercising market power

Body image as a predictor of nonsuicidal self-injury in women: a longitudinal study

Objectives: To determine whether Body Image Dissatisfaction (BID) predicted NonSuicidal Self-Injury (NSSI) cross-sectionally and longitudinally, independent of comorbidity between NSSI and Disordered Eating (DE). Another aim was to determine whether BID could predict number of NSSI methods present. Method: Adult females completed measures of NSSI and DE (n = 283); and a longitudinal sample (n = 106) completed these measures again one year later. Results: BID was a small yet significant predictor of NSSI both cross-sectionally and longitudinally. Poorer BID significantly explained a greater number of NSSI methods cross-sectionally and longitudinally. Conclusions: BID explains unique variance in NSSI (including increased number of methods), and is not a function of comorbidity with DE. This has the potential to influence theory, as well as inform early intervention initiatives for BID in females. Further research is required to determine other variables implicated in this relationship, as well as whether these findings are applicable to other groups such as adolescents and males

A confluence of cultures: advance care planning in long-term care settings

Context: While policies may promote Advance Care Planning (ACP) discussions in long-term care (LTC) settings, practices often result in outcomes different from residents’ wishes. We attribute this to a confluence of cultures: healthcare; LTC settings; mainstream societal; and individuals’ ethno-cultures. This research explores these cultures as reflected in focus group discussions conducted with residents and family-of-residents in two LTC homes: one exclusively Chinese (EC); one multicultural (MC). Method: Fourteen residents and 13 family members participated in the four focus groups. Discussions were audio-recorded, transcribed, and themes were extracted and compared. Results: Four themes characterized residents’ discussions: 1-Variations in Range/Type of ACP Discussions/Actions; 2-Care of Family; 3-Reliance on Staff; and 4-Quality-of-Life at End-of-Life. Exclusively Chinese residents expressed reluctance to speak about ACP, were more likely to state “family would handle it,” less likely to call upon staff, and more acquiescent concerning death. Multicultural residents were more likely to pejoratively mention pull or absence of family and reliance upon staff; also, wanting personal awareness and control at end-of-life. Family themes were 1-Timing/Focus of ACP Discussions, 2-Communication with Family, 3-Care Home and Staff Influences, and 4-Cultural and Religious Issues. Exclusively Chinese families spoke of need to involve family in ACP discussions inclusive of residents and of Chinese cultural influences on ACP. Multicultural families reported being “taken by surprise” and feeling “overwhelmed” by requests to engage in ACP and document completion on behalf of residents. Conclusion: Findings provide evidence of multiple cultural influences on ACP in LTC but existing institutional policies and practices offer little direction and support on how to balance/prioritize them. Our analyses may provide a starting point

PAR-1 Kinase Phosphorylates Dlg and Regulates Its Postsynaptic Targeting at the Drosophila Neuromuscular Junction

SummaryTargeting of synaptic molecules to their proper location is essential for synaptic differentiation and plasticity. PSD-95/Dlg proteins have been established as key components of the postsynapse. However, the molecular mechanisms regulating the synaptic targeting, assembly, and disassembly of PSD-95/Dlg are not well understood. Here we show that PAR-1 kinase, a conserved cell polarity regulator, is critically involved in controlling the postsynaptic localization of Dlg. PAR-1 is prominently localized at the Drosophila neuromuscular junction (NMJ). Loss of PAR-1 function leads to increased synapse formation and synaptic transmission, whereas overexpression of PAR-1 has the opposite effects. PAR-1 directly phosphorylates Dlg at a conserved site and negatively regulates its mobility and targeting to the postsynapse. The ability of a nonphosphorylatable Dlg to largely rescue PAR-1-induced synaptic defects supports the idea that Dlg is a major synaptic substrate of PAR-1. Control of Dlg synaptic targeting by PAR-1-mediated phosphorylation thus constitutes a critical event in synaptogenesis

AN EXAMINATION OF THE ABSENCE OF ESTABLISHED MOOSE (ALCES ALCES) POPULATIONS IN SOUTHEASTERN CAPE BRETON ISLAND, NOVA SCOTIA, CANADA

An analysis was performed on habitat-related factors for the southeastern side of Cape Breton Island, Nova Scotia to investigate the continued absence of moose (Alces alces) from the region. Temperature and snow depth, at times, reach levels that could cause thermal stress or impede movement of moose; however, it is unlikely that these factors dictate the absence of moose. No clear relationships were established between environmental concentration levels of the heavy metals molybdenum, cadmium, copper, and lead and moose distribution; however, high concentration levels of molybdenum in the Cape Breton study area warrant further investigation. Road density assessments showed that the study area has a higher level of road density compared to 2 mainland control sites; however, higher road density occurs in other areas in which moose persist. Anthropogenic factors such as poaching were not considered influential enough to exclude moose. A forest habitat comparison analysis was performed to identify habitat features that were statistically correlated with moose presence, and then were applied in a probability model to predict moose presence in the study area. The logistic regression model used to predict the probability of moose presence was composed of positively associated forest inventory variables (softwood average maturity, hardwood average maturity, % mixed hardwood, % non-forested area, total wetland area) that best fit the data. The model identified 43% of the Cape Breton study area as having a high-probability weighting for moose presence. Overall, this study did not reveal a clearly identifiable cause for the continued absence of moose in southeastern Cape Breton Island

Modeling the Demand for Food Safety and the Implications for Regulation

The modern theory of demand which underlies much of economic analysis of consumer behavior is based on the premise that consumption goods are pure and do not involve risks. However, that is clearly not the case where concerns about food safety are involved. The awareness of linkages between consumption of foods and adverse health effects indicates the need for a new framework for investigating demand for food and food safety, and for guiding the appropriate government response to achieve optimal regulation of food safety levels. We develop such a framework and show that when safety is endogenous to the consumer's decision over a consumption bundle, perfect safety is not optimal. There are several implications of the model. Empirical analysis based on conventional demand theory may lack predictive power due to model misspecification and the unobserved survival probability function. Furthermore, if markets are perfectly competitive and consumers accurately informed about safety risk, there is no need for government regulation. However, when markets are not perfectly competitive, and answer is less clear-cut. And, risk differentiation may become a new basis for acquiring and exercising market power.

Digital interventions in alcohol and drug prevention, treatment and recovery: Systematic maps of international research and interventions available in England

Executive Summary Background Digital interventions in alcohol and drug prevention, treatment and recovery have the potential to overcome barriers faced by non-digital interventions. However, we lack a clear understanding of the types of digital interventions that have been evaluated and where gaps in the evidence base exist. We also need to understand the effectiveness of different types of digital alcohol and drug interventions for various population groups. Further, we do not know which digital alcohol and drug interventions are being used in England, and whether the interventions in use align with those that have been evaluated. Research questions To address the above concerns, we sought to address the following questions: • RQ1: What is the possible range of digital alcohol and drug interventions? • RQ2: Which types of digital alcohol and drug interventions are currently available for use in England? • RQ3: What systematic reviews provide findings for digital alcohol and drug intervention strategies within a prevention/treatment/recovery pathway? • RQ4: Which types of digital alcohol and drug interventions have been evaluated in primary research? • RQ5: To what extent does the evaluation evidence overlap with digital alcohol and drug interventions that are currently available for use in England? • RQ6: What evidence is there that certain types of digital alcohol and drug interventions are (cost-) effective or ineffective for specific population groups or in particular contexts? This report covers our findings in relation to questions RQ1 - RQ5. Based on these findings we also provide suggestions as to what could be the focus of further work to answer RQ6. Methods To address RQ1 an initial typology was drafted, adapting and building on existing typologies of digital interventions. Through this process it became clear to OHID/PHE that a pathway, presenting a route through services, with different types of interventions recommended for use at different times would be more helpful than a typology of intervention characteristics. This pathway was then developed by OHID/PHE and trialled by the research team, with refinements made over time with discussions between the study team and PHE. To address RQ2 we contacted people in England in 2019, who were involved in developing, commissioning, prescribing, recommending or evaluating digital alcohol/drug interventions. Using an online survey, we asked them to describe the interventions they were involved with. To address RQ3, RQ4 and RQ5 we conducted systematic searching and screening to identify and describe existing systematic reviews (RQ3) and primary studies (RQ4). Included systematic reviews were appraised for quality and detailed information was extracted from full reports. For primary studies we extracted basic details using the information contained within the title and abstract. The pathway developed for RQ1 was employed to code and describe the nature of available interventions (RQ2), systematic reviews (RQ3) and primary studies (RQ4). EPPI-Mapper software was used to produce online interactive maps to visually display the findings

Variation of the Linguistic Profiles of Advanced English-Speaking Learners of Korean

This paper, which is a"partial replication of Kanno et a1. (to appear), examined the linguistic profiles of 27 advanced English-speaking learners of Korean (23 heritage, four non-heritage). Data consisted of performance by all 27 subjects on an adapted Korean version of Kanno et at's written test of linguistic intuitions, and six subjects' rendition of the same guided spoken narrative was also analyzed for accuracy and complexity. Results showed that advanced learners of Korean found idiomatic expressions and passive constructions to be the most difficult; heritage learners outperformed non-heritage learners on all areas of the first written test; heritage learners found connectives easy, while non-heritage learners found them difficult; and among heritage learners, the higher their proficiency, the easier they found honorifics