112 research outputs found
Co-opted by U.S. Capital: A Diachronic Study of Korean Americans’ Relation to the Model Minority Myth
This paper examines the historical conditions within which Korean Americans became a “model minority,” linking transnational Korean history to the diasporic formations around the model minority stereotypes. It advances that Korean Americans’ conceptualization of their economic success borrows heavily from the narrative of Korea’s postwar economic development, which itself resulted from the nation’s desire to overcome the past of Japanese colonialism. For instance, the Korean American small business owners interviewed in Sai-I-Gu, a documentary about the 1992 Los Angeles uprising, emphasize the values of hard work, thrift, and sacrifice when telling their immigrant stories, echoing media representations of Korea’s postwar economic success. As a result of these resonances, however, Korean American self-representation has become profoundly implicated in the mechanisms of U.S. capitalism, often to the harm of those minority groups who are not as easily co-opted by U.S. capitalist society
For a New Ethics of Reading: Analyzing Tea in the Harem’s Reception
This paper examines the extratextual materials that reified the novel/film Tea in the Harem as an archive of knowledge about the beur community. I argue that Tea in the Harem was subjected to what I call an anthropological approach to literature, a reading practice which instrumentalizes and subordinates the text to the historical reality which it is said to represent. Though in many ways entangled with the principles of French republicanism, the reception of Tea in the Harem is symptomatic of a more general phenomenon in which literatures of “the other” are expected to rehabilitate, educate, and civilize the majority mind through their treatment of sociopolitically sensitive subjects. Charting the way for a new ethics of reading, this paper interrogates the prevailing value system which all too easily demands of socially marginalized authors an “authentic” representation of their reality, limiting authorial imagination to mere mimesis
The Automorphism Group of the Infinite-Rank Free Group is Coarsely Bounded
We prove that the full automorphism group and the outer automorphism group of
the free group of countably infinite rank are coarsely bounded. That is, these
groups admit no continuous actions on a metric space with unbounded orbits, and
have the quasi-isometry type of a point.Comment: 4 pages. v2: Incorporated referee's comment. To appear in New York
Journal of Mathematic
Generating Sets and Algebraic Properties of Pure Mapping Class Groups of Infinite Graphs
We completely classify the locally finite, infinite graphs with pure mapping
class groups admitting a coarsely bounded generating set. We also study
algebraic properties of the pure mapping class group: We establish a semidirect
product decomposition, compute first integral cohomology, and classify when
they satisfy residual finiteness and the Tits alternative. These results
provide a framework and some initial steps towards quasi-isometric and
algebraic rigidity of these groups.Comment: 36 pages, 10 figure
The physical nature of spiral wave patterns in sunspots
Recently spiral wave patterns (SWPs) have been detected in 3-min oscillations of sunspot umbrae, but the nature of this phenomenon has remained elusive. We present a theoretical model which interprets the observed SWPs as the superposition of two different azimuthal modes of slow magnetoacoustic waves driven below the surface in an untwisted and non-rotating magnetic cylinder. We apply this model to SWPs of the line-of-sight velocity in a pore observed by the Fast Imaging Solar Spectrograph installed at the 1.6 m Goode Solar Telescope. One- and two-armed SWPs were identified in instantaneous amplitudes of line-of-sight Doppler velocity maps of 3-min oscillations. The associated oscillation periods are about 160 seconds, and the durations are about5 minutes. In our theoretical model, the observed spiral structures are explained by the superposition of non-zero azimuthal modes driven 1600 km below the photosphere in the pore. The one-armed SWP is produced by the slow body sausage (m= 0) and kink(m= 1) modes, and the two-armed SWP is formed by the slow body sausage (m= 0)and fluting (m= 2) modes of the magnetic flux tube forming the pore
Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea
BACKGROUND
Antibiotic-resistant Neisseria gonorrhoeae has prompted the development of new therapies. Zoliflodacin is a new antibiotic that inhibits DNA biosynthesis. In this multicenter, phase 2 trial, zoliflodacin was evaluated for the treatment of uncomplicated gonorrhea.
METHODS
We randomly assigned eligible men and women who had signs or symptoms of uncomplicated urogenital gonorrhea or untreated urogenital gonorrhea or who had had sexual contact in the preceding 14 days with a person who had gonorrhea to receive a single oral dose of zoliflodacin (2 g or 3 g) or a single 500-mg intramuscular dose of ceftriaxone in a ratio of approximately 70:70:40. A test of cure occurred within 6±2 days after treatment, followed by a safety visit 31±2 days after treatment. The primary efficacy outcome measure was the proportion of urogenital microbiologic cure in the microbiologic intention-to-treat (micro-ITT) population.
RESULTS
From November 2014 through December 2015, a total of 179 participants (167 men and 12 women) were enrolled. Among the 141 participants in the micro-ITT population who could be evaluated, microbiologic cure at urogenital sites was documented in 55 of 57 (96%) who received 2 g of zoliflodacin, 54 of 56 (96%) who received 3 g of zoliflodacin, and 28 of 28 (100%) who received ceftriaxone. All rectal infections were cured in all 5 participants who received 2 g of zoliflodacin and all 7 who received 3 g, and in all 3 participants in the group that received ceftriaxone. Pharyngeal infections were cured in 4 of 8 participants (50%), 9 of 11 participants (82%), and 4 of 4 participants (100%) in the groups that received 2 g of zoliflodacin, 3 g of zoliflodacin, and ceftriaxone, respectively. A total of 84 adverse events were reported: 24 in the group that received 2 g of zoliflodacin, 37 in the group that received 3 g of zoliflodacin, and 23 in the group that received ceftriaxone. According to investigators, a total of 21 adverse events were thought to be related to zoliflodacin, and most such events were gastrointestinal.
CONCLUSIONS
The majority of uncomplicated urogenital and rectal gonococcal infections were successfully treated with oral zoliflodacin, but this agent was less efficacious in the treatment of pharyngeal infections
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Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine
Targeted cancer therapy requires the rapid and accurate identification of genetic abnormalities predictive of therapeutic response. We sought to develop a high-throughput genotyping platform that would allow prospective patient selection to the best available therapies, and that could readily and inexpensively be adopted by most clinical laboratories. We developed a highly sensitive multiplexed clinical assay that performs very well with nucleic acid derived from formalin fixation and paraffin embedding (FFPE) tissue, and tests for 120 previously described mutations in 13 cancer genes. Genetic profiling of 250 primary tumours was consistent with the documented oncogene mutational spectrum and identified rare events in some cancer types. The assay is currently being used for clinical testing of tumour samples and contributing to cancer patient management. This work therefore establishes a platform for real-time targeted genotyping that can be widely adopted. We expect that efforts like this one will play an increasingly important role in cancer management
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