Efficiency of nickel and chromium removal from child's body through physical activities

© 2020 EDIZIONIMINERVAMEDICA. BACKGROUND: At present, a large number of people live in unfavorable environmental conditions that adversely affect the health of the population, including children. Therefore, it is necessary to look for ways and create methods for removing harmful substances from the body, including physical culture means. METHODS: The following methods were used for the study: Analysis and synthesis of literary sources, atomic absorption analysis, pedagogical experiment, pedagogical observation. RESULTS: The research was conducted in a sanatorium located in a relatively environment-friendly area. More than 1000 preschool children participated in the study. To remove excess nickel and chromium we applied the following techniques in the experimental group: Hiking using cold-protective clothing, swimming in the pool, combined effects of hiking and saunas, saunas and swimming in the pool. The control group followed the standard program of the sanatorium. The results of the research showed that the most effective way for removing nickel from the body of children living in unfavorable environmental areas is physical activity in the pool; for the removal of chromium the most effective way is the combined effect of aquatic physical loads and thermal-air loading. CONCLUSIONS: The children from unfavorable environmental areas have higher content of heavy metals in the solid biological media; to reduce it, these metals must be removed through physical activity; the most effective way for removing nickel from the body of the children living in unfavorable environmental areas is the impact of physical exercises done in the pool; the most effective way for removing chromium from the body of the children living in unfavorable environmental areas is the complex impact of aquatic physical activity in combination with thermal-air loading

The extent of B-cell activation and dysfunction preceding lymphoma development in HIV-positive people

Objectives: B-cell dysfunction and activation are thought to contribute to lymphoma development in HIV-positive people; however, the mechanisms are not well understood. We investigated levels of several markers of B-cell dysfunction [free light chain (FLC)-\u3ba, FLC-\u3bb, immunoglobulin G (IgG), IgA, IgM and IgD] prior to lymphoma diagnosis in HIV-positive people. Methods: A nested matched case\u2013control study was carried out within the EuroSIDA cohort, including 73 HIV-positive people with lymphoma and 143 HIV-positive lymphoma-free controls. Markers of B-cell dysfunction were measured in prospectively stored serial plasma samples collected before the diagnosis of lymphoma (or selection date in controls). Marker levels 64 2 and > 2 years prior to diagnosis were investigated. Results: Two-fold higher levels of FLC-\u3ba [odds ratio (OR) 1.84; 95% confidence interval (CI) 1.19, 2.84], FLC-\u3bb (OR 2.15; 95% CI 1.34, 3.46), IgG (OR 3.05; 95% CI 1.41, 6.59) and IgM (OR 1.46; 95% CI 1.01, 2.11) were associated with increased risk of lymphoma > 2 years prior to diagnosis, but not 64 2 years prior. Despite significant associations > 2 years prior to diagnosis, the predictive accuracy of each marker was poor, with FLC-\u3bb emerging as the strongest candidate with a c-statistic of 0.67 (95% CI 0.58, 0.76). Conclusions: FLC-\u3ba, FLC-\u3bb and IgG levels were higher > 2 years before lymphoma diagnosis, suggesting that B-cell dysfunction occurs many years prior to lymphoma development. However, the predictive value of each marker was low and they are unlikely candidates for risk assessment for targeted intervention