Functional state of the chewing muscle group in the musculo-articular dysfunction of the temporomandibular joint in patients with chronic generalized periodontitis

This article is devoted to the diagnosis of musculo-articular dysfunction (MSD) of the temporomandibular joint (TMJ) in patients with chronic generalized periodontitis (CGP). The purpose of our work was to study the functional state of the masticatory group of muscles and facial muscles in MSD of the TMJ in patients with CGP. MATERIALS AND METHODS: A clinical examination of 89 patients aged 35-45 years with CHP and MSD was performed. Diagnostic models were studied in the articulator PROTAR (Germany), electromyography was performed. Results: In patients with MSJ, the EMJ significantly changes the electromyographic (EMG) pattern: there appears spontaneous EMG activity of the masticatory muscles and facial muscles during the period of physiological dormancy, the activity of the temporal muscles increases. In the presence of MSD of the TMJ and bruxism in patientsДанная статья посвящена диагностике мышечно-суставной дисфункции (МСД) височно-нижнечелюстного сустава (ВНЧС) у пациентов с хроническим генерализованным пародонтитом (ХГП). Целью нашей работы явилось изучение функционального состояния жевательной группы мышц и мимических мышц при МСД ВНЧС у пациентов с ХГП. Материалы и методы: произведено клиническое обследование 89 пациентов в возрасте 35-45 лет с ХГП и МСД. Изучали диагностические модели в артикуляторе PR0TAR (Германия), проводили электромиографию. Результаты: у пациентов с МСД ВНЧС значительно изменяется злектромиографическая (ЭМГ) - картина: появляется спонтанная ЭМГ-активность жевательных мышц и мимических мышц в период физиологического покоя, повышается активность височных мышц. При наличии МСД ВНЧС и бруксизма у пациентов с ХГП присутствует спонтанная ЭМГ-активность жевательных и мимических мышц в период физиологического покоя

Influence of tetrafunctional polylactide morphology on regeneration of bone tissue defects

Определено влияние длины разветвленных цепей сшитых тетрафункциональных полилкатидов на микроморфологию поверхности. Оценены механические свойства структурированных скаффолдов в режиме PeakForce QNM (MultiMode 8, ruker, США). Подобран оптимальный по своим механическим и поверхностным характеристикам тип полилактидов для полной регенерации созданного костного дефекта ткани мышиThe influence of the length of branched chains of cross-linked tetrafunctional polyclatides on the surface micromorphology is determined. The mechanical properties of structured scaffolds are estimated in the PeakForce QNM mode (MultiMode 8, Bruker, USA). Optimal type of polylactide for its mechanical and surface characteristics was selected for complete regeneration of the created bone defect in mouse tissue

Relationship of matrix metalloproteinase-3 -11715A/6A polymorphism (rs35068180) and dilated cardiomyopathy

Aim. To study the relationship of matrix metalloproteinase-3 (MMP3) genetic polymorphism and dilated ischemic cardiomyopathy (DCM), as well as idiopathic cardiomyopathy (ICM) of unknown etiology.Material and methods. A total of 221 patients with DCM and ICM were examined (mean age, 55,30±9,69 years). The group of ischemic DCM consisted of 111 people (99 men (89,2%) and 12 women (10,8%)). The mean age of DCM subjects was 51,73±9,74 years (male subgroup, 51,00±8,96 years; female subgroup, 57,75±3,71 years). The ICM group consisted of 110 people (100 men (91,5%) and 10 women (8.5%)). The mean age of ICM subjects was 58,68±8.38 years (male subgroup, 58,29±8.,6 years; female subgroup, 62,90±6,29 years). The control group of subjects (n=121) consisted of healthy people without cardiovascular diseases (mean age, 53,6±4,8 years). All patients of the experimental group underwent routine diagnostic tests, as well as coronary angiography. In case of suspected myocarditis, cardiac magnetic resonance imaging was performed. All patients underwent polymerase chain reaction to determine the MMP3-11715A/6A polymorphism (rs35068180).Results. In patients with cardiomyopathy, regardless of the disease origin, significant differences were verified in comparison with the control group. Allele 6A (65,8% vs 59,3%, p=0,044) and genotype 6A/6A (42,1% vs 32,6%, p=0,099) were found significantly more frequently in patients with cardiomyopathy than in the control group. In addition, despite various etiological factors, the pathogenetic involvement of MMP3 is likely to have a general direction.Conclusion. In all patients with cardiomyopathy, the prevalence of MMP3 gene A allele was shown. Due to decrease in the transcription activity in homozygous 6A allele, the stromelysin level in arterial walls also decreases. This promotes the activation of procollagenase-1, the deposition of extracellular matrix and cardiac remodelin

Features of Isotypic Structure of Virus-Specific Systemic Humoral Immune Response in Adult Volunteers Immunized with Inactivated Monovalent Subunit Vaccines against Pandemic Influenza A(H1N1)pdm09

An isotypic structure of system antibody response to influenza A(H1N1)pdm09 was analyzed in adult volunteers vaccinated with two inactivated monovalent subunit vaccines against pandemic influenza. The comparison group consisted of patients infected with influenza A(H1N1)pdm09 virus. In vaccinated volunteers the more active response of influenza-specific antibodies both with neutralizing properties (IgG1, IgG2, IgG3) and associated with allergic inflammation (IgG and IgE) was observed in comparison with infected patients. The high activity of the virus-specific serum IgA was observed both in infected patients and vaccinated volunteers. Antiviral hemagglutinating activity of antibodies in post-vaccination sera of vaccinated volunteers, unlike sera obtained from infected patients in the phase of recovery, were higher than protective level (1:40) according to HAI data

RUSSIAN EXPERTS’ CONSENSUS ON METABOLIC SYNDROME PROBLEM IN THE RUSSIAN FEDERATION: DEFENITION, DIAGNOSIS CRITERIA, PRIMARY PREVENTION AND TREATMENT

Russian Experts’ Consensus on Metabolic Syndrome Problem in the Russian Federation: Defenition, Diagnosis Criteria, Primary Prevention and Treatment

The Middle and Late Pleniglacial (Weichselian) malacofauna of the Zemun loess–paleosol sequence, Serbia

The aim of our study was to describe the succession of malacological assemblages along the exposed loess profile located in Belgrade, along the banks of the Danube River (municipality of Zemun). Deposits that belong to the composite loess unit L1 were sampled. Loess unit L1 included two subunits: L1SS1 (a Middle Pleniglacial subunit with two weakly developed initial pedogenic horizons) and L1LL1 (a Late Pleniglacial loess subunit). Three malacological zones were distinguished. Malacological results imply a change in climatic conditions and subsequently in vegetation structure. The molluscs indicate an environment with a moderate (warm and dry) climate and a mosaic vegetation type composed of grasslands and forest steppe. Gradual cooling was inferred within the Late Pleniglacial period. Our findings concur with the results of earlier studies indicating that the Zemun site and the adjacent area served as a transition zone between the refuge areas within the southeastern part of the Carpathian Basin during the Late Pleistocene