New titanium and zirconium sandwich and half-sandwich complexes containing the C(5)Me(4)CH(2)CH(2)CH=CH2(Cp(=)) ligand

The syntheses and characterization of new titanium and zirconium derivatives of the C5Me4CH2CH2CH=CH2(Cp =) ligand are described. Reaction of LiCp= with ZrCl4 in diethyl ether afforded the half-sandwich derivative [Zr2(η-Cp=)2Cl4(μ-Cl) 2] which is a precursor to the mixed-ring zirconocenes [Zr(η-Cp=)(η-C5H5)Cl2] and [Zr(η-Cp=)(η-C5Me5)Cl2]. Reaction of LiCp= with ZrCl4 in toluene followed by crystallization in the presence of dme (1,2-dimethoxyethane) gave the unusual complex [Zr2(η-Cp=)2Cl2(μ-Cl) 3Li(dme)] (X-ray structure) in which a {Zr2(η-Cp=)2Cl4(μ-Cl) 3}- moiety formally acts as a tetradentate ligand to a {Li(dme)}+ fragment. Treatment of [TiCl3(thf)3] with LiCp= followed by HCl gave the half-sandwich titanium derivative [Ti(η-Cp=)Cl3] and addition of one equivalent of LiCp= to a solution of [Ti(NBut)Cl2(4-NC5H4Bu t)2] gave the corresponding imido complex [Ti(η-Cp=)(NBut)Cl(4-NC5H 4But)] in quantitative yield

Physical function and quality of life in patients with chronic graft-versus-host-disease: A summary of preclinical and clinical studies and a call for exercise intervention trials in patients

Allogeneic Hematopoietic Stem Cell Transplant, to reconstitute hematopoietic and immune status of patients undergoing myeloablative therapy for hematologic disorders, has been of great benefit in minimizing or eradicating disease and extending survival. Patients who undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) are subject to many comorbidities among which the most significant, affecting quality of life (QoL) and survival, are acute (aGVHD) and chronic Graft Versus Host Disease (cGVHD), resulting from donor lymphocytes reacting to and damaging host tissues. Physical activity and exercise have clearly been shown, in both children and adults, to enhance fitness, improve symptomatology and QoL, reduce disease progression and extend survival for many diseases including malignancies. In some cases, vigorous exercise has been shown to be equal to or more effective than pharmacologic therapy. This review addresses how cGVHD affects patients’ physical function and physical domain of QoL, and the potential benefits of exercise interventions along with recommendations for relevant research and evaluation targeted at incorporating this strategy as soon as possible after allo-HSCT and ideally, as soon as possible upon diagnosis of the condition leading to allo-HSCT.Sin financiación3.874 JCR (2016) Q2, 20/70 Hematology, 48/151 Immunology, 71/217 Oncology, 7/25 Transplantation1.986 SJR (2016) Q1, 18/135 Hematology, 5/42 TransplantationNo data IDR 2016UE