Development of Hybrid Resistive Plate Chambers

Resistive Plate Chambers (RPCs) are essential active media of large-scale experiments as part of the muon systems and (semi-)digital hadron calorimeters. Among the several outstanding issues associated with the RPCs, the loss of efficiency for the detection of particles when subjected to high particle fluxes, and the limitations associated with the common RPC gases can be listed. In order to address the latter issue, we developed novel RPC designs with special anode plates coated with high secondary electron emission yield materials such as Al$_2$O$_3$ and TiO$_2$. The proof of principle was obtained for various designs and is in progress for the rest. The idea was initiated following the achievements on the development of the novel 1-glass RPCs. Here we report on the construction of various different RPC designs, and their performance measurements in laboratory tests and with particle beams; and discuss the future test plans

Preserving Alveolar Bone Growth Following Cervical Root Fracture: A Case Report

Root fracture injuries affect 0.5%–7% of permanent teeth. Although cervical root fractures are less frequent in children, their serious consequences and poor prognosis may lead to tooth loss. In this case presentation, we discuss a treatment approach chosen to preserve alveolar bone growth following a cervical root fracture in an 8-year-old boy

RCytoscape: Tools for Exploratory Network Analysis

Background: Biomolecular pathways and networks are dynamic and complex, and the perturbations to them which cause disease are often multiple, heterogeneous and contingent. Pathway and network visualizations, rendered on a computer or published on paper, however, tend to be static, lacking in detail, and ill-equipped to explore the variety and quantities of data available today, and the complex causes we seek to understand. Results: RCytoscape integrates R (an open-ended programming environment rich in statistical power and datahandling facilities) and Cytoscape (powerful network visualization and analysis software). RCytoscape extends Cytoscape\u27s functionality beyond what is possible with the Cytoscape graphical user interface. To illustrate the power of RCytoscape, a portion of the Glioblastoma multiforme (GBM) data set from the Cancer Genome Atlas (TCGA) is examined. Network visualization reveals previously unreported patterns in the data suggesting heterogeneous signaling mechanisms active in GBM Proneural tumors, with possible clinical relevance. Conclusions: Progress in bioinformatics and computational biology depends upon exploratory and confirmatory data analysis, upon inference, and upon modeling. These activities will eventually permit the prediction and control of complex biological systems. Network visualizations -- molecular maps -- created from an open-ended programming environment rich in statistical power and data-handling facilities, such as RCytoscape, will play an essential role in this progression

Percutaneous Endoscopic Gastrostomy in a Patient with a History of Subtotal Gastrectomy: A Case Report

While percutaneous endoscopic gastrostomy (PEG) has been used successfully for many years in patients for whom oral intake is not possible, it has been thought not to be a feasible procedure for patients who have had previous gastric surgery. However, history of a previous partial gastrectomy is no longer considered a contraindication for PEG-placement. In this case, we aimed to report an 83-year-old patient with a history of subtotal gastrectomy who required a PEG for enteral feeding because of cerebrovascular event

Aggressive Angiomyxoma: A Rare Tumor of Male Pelvic Cavity

Aggressive angiomyxoma is an uncommon, benign, slow-growing, and locally infiltrative soft tissue neoplasm which is located primarily in the genital region and pelviperineal interstitial tissue of female patient in the fourth decade of life. Its occurrence in male patients is even more unusual and commonly appears at a later age. The mainstay of treatment typically involves surgical excision with tumor-free margins, and despite complete resection, local recurrences are common. Here, an unusual case of aggressive angiomyxoma occurring in the pelvic region of a 55-year-old man and its treatment is discussed due to its rarity

Detailed transcriptome atlas of the pancreatic beta cell

BACKGROUND: Gene expression patterns provide a detailed view of cellular functions. Comparison of profiles in disease vs normal conditions provides insights into the processes underlying disease progression. However, availability and integration of public gene expression datasets remains a major challenge. The aim of the present study was to explore the transcriptome of pancreatic islets and, based on this information, to prepare a comprehensive and open access inventory of insulin-producing beta cell gene expression, the Beta Cell Gene Atlas (BCGA). METHODS: We performed Massively Parallel Signature Sequencing (MPSS) analysis of human pancreatic islet samples and microarray analyses of purified rat beta cells, alpha cells and INS-1 cells, and compared the information with available array data in the literature. RESULTS: MPSS analysis detected around 7600 mRNA transcripts, of which around a third were of low abundance. We identified 2000 and 1400 transcripts that are enriched/depleted in beta cells compared to alpha cells and INS-1 cells, respectively. Microarray analysis identified around 200 transcription factors that are differentially expressed in either beta or alpha cells. We reanalyzed publicly available gene expression data and integrated these results with the new data from this study to build the BCGA. The BCGA contains basal (untreated conditions) gene expression level estimates in beta cells as well as in different cell types in human, rat and mouse pancreas. Hierarchical clustering of expression profile estimates classify cell types based on species while beta cells were clustered together. CONCLUSION: Our gene atlas is a valuable source for detailed information on the gene expression distribution in beta cells and pancreatic islets along with insulin producing cell lines. The BCGA tool, as well as the data and code used to generate the Atlas are available at the T1Dbase website (T1DBase.org).Journal Articleinfo:eu-repo/semantics/publishe

T1DBase: integration and presentation of complex data for type 1 diabetes research

T1DBase () [Smink et al. (2005) Nucleic Acids Res., 33, D544–D549; Burren et al. (2004) Hum. Genomics, 1, 98–109] is a public website and database that supports the type 1 diabetes (T1D) research community. T1DBase provides a consolidated T1D-oriented view of the complex data world that now confronts medical researchers and enables scientists to navigate from information they know to information that is new to them. Overview pages for genes and markers summarize information for these elements. The Gene Dossier summarizes information for a list of genes. GBrowse [Stein et al. (2002) Genome Res., 10, 1599–1610] displays genes and other features in their genomic context, and Cytoscape [Shannon et al. (2003) Genome Res., 13, 2498–2504] shows genes in the context of interacting proteins and genes. The Beta Cell Gene Atlas shows gene expression in β cells, islets, and related cell types and lines, and the Tissue Expression Viewer shows expression across other tissues. The Microarray Viewer shows expression from more than 20 array experiments. The Beta Cell Gene Expression Bank contains manually curated gene and pathway annotations for genes expressed in β cells. T1DMart is a query tool for markers and genotypes. PosterPages are ‘home pages’ about specific topics or datasets. The key challenge, now and in the future, is to provide powerful informatics capabilities to T1D scientists in a form they can use to enhance their research

Muhasebe ve vergi yönüyle finansal kiralama işlemleri

Çalışmamda, kiralama işleminin tarihsel gelişimi, finansal kiralama işlemleriningelişim süreci ve finansal kiralama işlemlerinin Dünya ve Türkiye’deki yeri, ülkemizdefinansal kiralama alanında yapılan ilk değişiklik olan 3226 Sayılı Finansal KiralamaKanunu, akabinde 213 Sayılı Vergi Usul Kanununda yapılan değişiklikle beraber finansalkiralama işleminin nasıl değerlemesi gerektiğine ilişkin açıklamaları içeren FinansalKiralama İşlemlerinde Değerleme başlıklı Mükerrer 290’ıncı madde, bu değişiklikleritakiben yayımlanan 6361 Sayılı Finansal Kiralama Faktoring ve Finansman ŞirketleriKanunun ve son olarak 17 Numaralı Türkiye Muhasebe Standardı ve bu standardı mülgahaline getiren 16 Numaralı Türkiye Finansal Raporlama Standardı yayımlanmıştır.Çalışmamda yasal mevzuatta yer alan açıklamalar, yasal mevzuatın birbiriyle olan uyumuve çelişkileri, uygulanabilirlik alanları, yasal mevzuat üzerinde yapılması gerekendeğişikliklerin neler olması gerektiği bu değişikliklerin nasıl sonuçlanacağı üzerindedurulmuştur.Bu bağlamda dünya üzerinde etkin bir finansman yöntemi olan finansalkiralamanın ülkemizde hali hazırda beklenilen talebi bulmaması, ülkemizde, finansalkiralamaya ilişkin düzenlemelerin sektörün ihtiyaçlarını karşılamada yeterli düzeydeolmadığı ve yenilenmesi gerektiği görülmüştür.--------------------In my work, the historical development of the lease, the place in the world andin Turkey the process of development and leasing transactions of leasing operations inour country, the first amendment to the lease area of 3226 numbered Leasing Law, howthe leasing transactions with the amendment made in 213 numbered Tax Procedure Law,then valuation of financial lease contains a statement that must valuation entitled repeated290'ınc article, published after these changes 6361 numbered Leasing Law Factoring andFinancing Companies and finally 17 numbered Turkey Accounting standards, and thatmakes this standard abolished 16 numbered Turkey Financial Reporting standards hasbeen published . In my study, the explanations in the legal legislation, the harmonizationand contradictions of the legal legislation with each other, the areas of applicability, thechanges that should be made on the legal legislation and how it should be emphasized arediscussed.In this context, it has been seen that financial leasing, which is an effectivefinancing method in the world, does not find the expected demand in our country and theregulations regarding leasing in our country are not sufficient to meet the needs of thesector and need to be renewed

Dağıtım kanallarında etkin risk yönetimi ve otomotiv sektöründe bir uygulama

ÖZETBilindiği gibi üretimin bir anlam ifade edebilmesi, malların tüketicilere doğru yerde ve doğru zamanda sunulabilmesine bağlıdır. Çünkü, günümüzde üretilen malların çok azı üretim yerinde tüketilir veya doğrudan üreticiden satın alınır. Oysa üretimin büyük bir kısmı araştırma, ilişki kurma, tutundurma, satın alıp yeniden satma, müşteri bulma, müzakere etme, finanslama, risk üstlenme gibi işlevleri yerine getiren aracılar tarafından tüketicilere ulaştırılmaktadır. Dolayısıyla bu aracılar, üretim ile tüketim arasında düzenleyici bir rol oynayarak dengeyi sağlamaktadırlar. Bu nedenle üretilen malın istenilen yerde ve zamanda tüketiciye sunulmasını içeren dağıtım faaliyetleri ve bu faaliyetleri yerine getiren aracılardan oluşan dağıtım kanallarının rolü küçümsenemeyecek kadar önemli olmaktadır. ABSTRACT Products are delivered to customer by the distribution channels. The important things are about products to delivering to customer , right time and right place. As is known, the products are not consumed production place by the customer. A substantial portion of manufacturing to delivered to custumer by the distribution channels members. These members are in charge of different kind of functions and these functions are resarches, relations, entertainig risks, sales, finding customer etc. Distribution channel members also have a role which is related to balance between manufacturing and consuming. Therefore distribution channels have an important role in Marketing area