Four-channel System for Characterization of Josephson Parametric Amplifiers

The axion search experiments based on haloscopes at the Center for Axion and Precision Physics Research (CAPP) of the Institute for Basic Science (IBS) in South Korea are performed in the frequency range from 1 GHz to 6 GHz. In order to perform the experiments in a strong magnetic field of 12 T and a large-volume cavity of close to 40 liters, we use He wet dilution refrigerators with immersed superconducting magnets. The measurements require continuous operation for months without interruptions for microwave component replacements. This is achieved by using different cryogenic engineering approaches including microwave RF-switching. The critical components, defining the scanning rate and the sensitivity of the setup, are the Josephson parametric amplifiers (JPA) and cryogenic low noise amplifiers (cLNA) based on high-electron-mobility-transistor (HEMT) technology. It is desirable for both devices to have a wide frequency range and low noise close to the quantum limit for the JPA. In this paper, we show a recent design of a 4-channel measurement setup for JPA and HEMT measurements. The setup is based on a 4-channel wideband noise source (NS) and is used for both JPA and HEMT gain and noise measurements. The setup is placed at 20 mK inside the dry dilution refrigerator. The NS is thermally decoupled from the environment using plastic spacers, superconducting wires and superconducting coaxial cables. We show the gain and noise temperature curves measured for 4 HEMT amplifiers and 2 JPAs in one cool-downComment: to be published in JPS Conference Proceedings (LT29

CAPP Axion Search Experiments with Quantum Noise Limited Amplifiers

The axion is expected to solve the strong CP problem of quantum chromodynamics and is one of the leading candidates for dark matter. CAPP in South Korea has several axion search experiments based on cavity haloscopes in the frequency range of 1-6 GHz. The main effort focuses on operation of the experiments with the highest possible sensitivity. It requires maintenance of the haloscopes at the lowest physical temperature in the range of mK and usage of low noise components to amplify the weak axion signal. We report development and operation of low noise amplifiers for 5 haloscope experiments targeting at different frequency ranges. The amplifiers show noise temperatures approaching the quantum limit.Comment: 6 pages, 7 figures, 29th International Conference on Low Temperature Physics, August 18-24, 2022, Sapporo, Japa

Near-Quantum-Noise Axion Dark Matter Search at CAPP around 9.5 μ\mueV

We report the results of an axion dark matter search over an axion mass range of 9.39-9.51 ${\mu}$eV. A flux-driven Josephson parametric amplifier (JPA) was added to the cryogenic receiver chain. A system noise temperature of as low as 200 mK was achieved, which is the lowest recorded noise among published axion cavity experiments with phase-insensitive JPA operation. In addition, we developed a two-stage scanning method which boosted the scan speed by 26%. As a result, a range of two-photon coupling in a plausible model for the QCD axion was excluded with an order of magnitude higher in sensitivity than existing limits.Comment: 6 pages, 4 figure

Josephson Parametric Amplifier in Axion Experiments

The axion is a hypothetical particle, a promising candidate for dark matter, and a solution to the strong CP problem. Axion haloscope search experiments deal with a signal power comparable to noise uncertainty at millikelvin temperature. We use a flux-driven Josephson parametric amplifier (JPA) with the aim of approaching a noise level near the theoretically allowed limit of half quanta. In our measurements to characterize the JPA we have found the added noise to the system with a JPA as the first-stage amplifier to be lower than 110 mK at the frequencies from 0.938 GHz to 0.963 GHz.Comment: to be published in JPS Conference Proceedings (LT29

Search for the Sagittarius Tidal Stream of Axion Dark Matter around 4.55 μ\mueV

We report the first search for the Sagittarius tidal stream of axion dark matter around 4.55 $\mu$eV using CAPP-12TB haloscope data acquired in March of 2022. Our result excluded the Sagittarius tidal stream of Dine-Fischler-Srednicki-Zhitnitskii and Kim-Shifman-Vainshtein-Zakharov axion dark matter densities of $\rho_a\gtrsim0.184$ and $\gtrsim0.025$ GeV/cm$^{3}$, respectively, over a mass range from 4.51 to 4.59 $\mu$eV at a 90% confidence level.Comment: 6 pages, 7 Figures, PRD Letter accepte

Extensive search for axion dark matter over 1\,GHz with CAPP's Main Axion eXperiment

We report an extensive high-sensitivity search for axion dark matter above 1\,GHz at the Center for Axion and Precision Physics Research (CAPP). The cavity resonant search, exploiting the coupling between axions and photons, explored the frequency (mass) range of 1.025\,GHz (4.24\,$\mu$eV) to 1.185\,GHz (4.91\,$\mu$eV). We have introduced a number of innovations in this field, demonstrating the practical approach of optimizing all the relevant parameters of axion haloscopes, extending presently available technology. The CAPP 12\,T magnet with an aperture of 320\,mm made of Nb$_3$Sn and NbTi superconductors surrounding a 37-liter ultralight-weight copper cavity is expected to convert DFSZ axions into approximately $10^2$ microwave photons per second. A powerful dilution refrigerator, capable of keeping the core system below 40\,mK, combined with quantum-noise limited readout electronics, achieved a total system noise of about 200\,mK or below, which corresponds to a background of roughly $4\times 10^3$ photons per second within the axion bandwidth. The combination of all those improvements provides unprecedented search performance, imposing the most stringent exclusion limits on axion--photon coupling in this frequency range to date. These results also suggest an experimental capability suitable for highly-sensitive searches for axion dark matter above 1\,GHz.Comment: A detailed axion dark matter article with 27 pages, 22 figure

Normobaric oxygen treatment improves neuronal survival functional recovery and axonal plasticity after newborn hypoxia-ischemia

Background: Newborn hypoxia ischemia (HI) is one of the most prevalent cases in the emergency and can result from fetal hypoxia during delivery. In HI, restricted blood supply to the fetal brain may cause epilepsy or mental disorders.Methods: In the present study, seven-day-old pups were subjected HI and treated with different normobaric oxygen (NBO) concentrations (21%, 70% or 100%). In the acute phase, we analyzed infarct area, disseminate neuronal injury and surviving neurons. In addition, we studied the regulation of PTEN and MMP-9 proteins which were suggested to be activated by HI in the ischemic tissue. Moreover, long-term effects of NBO treatments were evaluated with open field, rotarod and Barnes maze tests. We also examined axonal plasticity with EGFP-AAV injection.Results: Here, we demonstrate that hyperoxic NBO concentration causes an increase in cellular survival and a decrease in the number of apoptotic cells, meanwhile inhibiting the proteins involved in cellular death mechanisms. Moreover, we found that hyperoxia decreases anxiety, promotes motor coordination and improve spatial learning and memory. Notably that axonal sprouting was promoted by hyperoxia.Conclusion: Our data suggest that NBO is a promising approach for the treatment of newborn HI, which encourage proof-of-concept studies in newborn.Turkish Academy of Sciences Necmettin Erbakan Universit

The role of repetative transcranial magnetic stimulation after focal cerebral ischemia

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Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity

WOS: 000464493200003PubMed ID: 31031599Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which the rTMS exert beneficial effects in cellular and molecular aspect are largely unknown. To elucidate the effects of high- and low-frequency rTMS in the acute-ischemic brain, we examined how rTMS influences injury development, cerebral blood flow (CBF), DNA fragmentation, neuronal survival, pro- and anti-apoptotic protein activations after 30 and 90 min of focal cerebral ischemia. In addition, inflammation, angiogenesis, growth factors and axonal outgrowth related gene expressions, were analyzed. Furthermore, we have investigated the effects of rTMS on post-acute ischemic brain, particularly on spontaneous locomotor activity, perilesional tissue remodeling, axonal sprouting of corticobulbar tracts, glial scar formation and cell proliferation, in which rTMS was applied starting 3 days after the stroke onset for 28 days. In the high-frequency rTMS received animals reduced DNA fragmentation, infarct volume and improved CBF were observed, which were associated with increased Bcl-xL activity and reduced Bax, caspase-1, and caspase-3 activations. Moreover, increased angiogenesis, growth factors; and reduced inflammation and axonal sprouting related gene expressions were observed. These results correlated with reduced microglial activation, neuronal degeneration, glial scar formation and improved functional recovery, tissue remodeling, contralesional pyramidal tract plasticity and neurogenesis in the subacute rTMS treated animals. Overall, we propose that high-frequency rTMS in stroke patients can be used to promote functional recovery by inducing the endogenous repair and recovery mechanisms of the brain.Turkish Academy of Sciences (TUBA); Necmettin Erbakan University [161318006]This work was funded by Turkish Academy of Sciences (TUBA) and Necmettin Erbakan University (Scientific Research Project No. 161318006)