384 research outputs found
Anomalous In-Plane Anisotropy of the Onset of Superconductivity in (TMTSF)2ClO4
We report the magnetic field-amplitude and field-angle dependence of the
superconducting onset temperature Tc_onset of the organic superconductor
(TMTSF)2ClO4 in magnetic fields H accurately aligned to the conductive ab'
plane. We revealed that the rapid increase of the onset fields at low
temperatures occurs both for H // b' and H // a, irrespective of the carrier
confinement. Moreover, in the vicinity of the Pauli limiting field, we report a
shift of a principal axis of the in-plane field-angle dependence of Tc_onset
away from the b' axis. This feature may be related to an occurrence of
Fulde-Ferrell-Larkin-Ovchinnikov phases.Comment: 4 pages, 4 figure
Pressure induced high-spin to low-spin transition in FeS evidenced by x-ray emission spectroscopy
We report the observation of the pressure-induced high-spin to low-spin
transition in FeS using new high-pressure synchrotron x-ray emission
spectroscopy techniques. The transition is evidenced by the disappearance of
the low-energy satellite in the Fe K emission spectrum of FeS. Moreover,
the phase transition is reversible and closely related to the structural phase
transition from a manganese phosphide-like phase to a monoclinic phase. The
study opens new opportunities for investigating the electronic properties of
materials under pressure.Comment: ReVTeX, 4 pages, 3 figures inserted with epsfig. minor modifications
before submission to PR
Magnetic-Field Variations of the Pair-Breaking Effects of Superconductivity in (TMTSF)2ClO4
We have studied the onset temperature of the superconductivity Tc_onset of
the organic superconductor (TMTSF)2ClO4, by precisely controlling the direction
of the magnetic field H. We compare the results of two samples with nearly the
same onset temperature but with different scattering relaxation time tau. We
revealed a complicated interplay of a variety of pair-breaking effects and
mechanisms that overcome these pair-breaking effects. In low fields, the linear
temperature dependences of the onset curves in the H-T phase diagrams are
governed by the orbital pair-breaking effect. The dips in the in-plane
field-angle phi dependence of Tc_onset, which were only observed in the
long-tau sample, provides definitive evidence that the field-induced
dimensional crossover enhances the superconductivity if the field direction is
more than about 19-degrees away from the a axis. In the high-field regime for
H//a, the upturn of the onset curve for the long-tau sample indicates a new
superconducting state that overcomes the Pauli pair-breaking effect but is
easily suppressed by impurity scatterings. The Pauli effect is also overcome
for H//b' by a realization of another state for which the maximum of
Tc_onset(phi) occurs in a direction different from the crystalline axes. The
effect on Tc_onset of tilting the applied field out of the conductive plane
suggests that the Pauli effect plays a significant role in determining
Tc_onset. The most plausible explanation of these results is that (TMTSF)2ClO4
is a singlet superconductor and exhibits Fulde-Ferrell-Larkin-Ovchinnikov
(FFLO) states in high fields.Comment: 12 pages, 10 figures. To be published in J. Phys. Soc. Jpn. (vol.77,
2008
Universal phase transitions of B1 structured stoichiometric transition-metal carbides
The high-pressure phase transitions of B1-structured stoichiometric
transition metal carbides (TMCs, TM=Ti, Zr, Hf, V, Nb, and Ta) were
systematically investigated using ab initio calculations. These carbides
underwent universal phase transitions along two novel phase-transition routes,
namely, B1\rightarrowdistorted TlI (TlI')\rightarrowTlI and/or
B1\rightarrowdistorted TiB (TiB')\rightarrowTiB, when subjected to pressures.
The two routes can coexist possibly because of the tiny enthalpy differences
between the new phases under corresponding pressures. Four new phases result
from atomic slips of the B1-structured parent phases under pressure. After
completely releasing the pressure, taking TiC as a representative of TMCs, only
its new TlI'-type phase is mechanically and dynamically stable, and may be
recovered.Comment: [email protected]
Human cell dedifferentiation in mesenchymal condensates through controlled autophagy
Tissue and whole organ regeneration is a dramatic biological response to injury that occurs across different plant and animal phyla. It frequently requires the dedifferentiation of mature cells to a condensed mesenchymal blastema, from which replacement tissues develop. Human somatic cells cannot regenerate in this way and differentiation is considered irreversible under normal developmental conditions. Here, we sought to establish in vitro conditions to mimic blastema formation by generating different three-dimensional (3D) condensates of human mesenchymal stromal cells (MSCs). We identified specific 3D growth environments that were sufficient to dedifferentiate aged human MSCs to an early mesendoderm-like state with reversal of age-associated cell hypertrophy and restoration of organized tissue regenerating capacity in vivo. An optimal auophagic response was required to promote cytoplasmic remodeling, mitochondrial regression, and a bioenergetic shift from oxidative phosphorylation to anaerobic metabolism. Our evidence suggests that human cell dedifferentiation can be achieved through autonomously controlled autophagic flux
Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer
Background
Suppressors of cytokine signaling (SOCS) are important negative feedback regulators of the JAK/STAT signaling pathway, and have been recently investigated for their role in the development of different cancers. In this study, we examined the expression of SOCS1-7 genes in normal and breast cancer tissue and correlated this with several clinico-pathological and prognostic factors.
Methods
SOCS1-7 mRNA extraction and reverse transcription were performed on fresh frozen breast cancer tissue samples (n = 127) and normal background breast tissue (n = 31). Transcript levels of expression were determined using real-time PCR and analyzed against TNM stage, tumour grade and clinical outcome over a 10 year follow-up period.
Results
SOCS1,4,5,6 and 7 expression decreased with increased TNM stage (TNM1 vs. TNM3 p = 0.039, TNM1 vs. TNM4 p = 0.016, TNM2 vs. TNM4 p = 0.025, TNM1 vs. TNM3 p = 0.012, and TNM1 vs. TNM3 p = 0.044 respectively). SOCS2 and 3 expression decreased with increased Nottingham Prognostic Index (NPI) (NPI1 vs. NPI3 p = 0.033, and NPI2 vs. NPI3 p = 0.041 respectively). SOCS7 expression decreased with higher tumour grade (Grade 3 vs. Grade 2 p = 0.037). After a median follow up period of 10 years, we found higher levels of SOCS1,2 and 7 expression among those patients who remained disease-free compared to those who developed local recurrence (p = 0.0073, p = 0.021, and p = 0.039 respectively). Similarly, we found higher levels of SOCS 2,4, and 7 expression in those who remained disease-free compared to those who developed distant recurrence (p = 0.022, p = 0.024, and p = 0.033 respectively). Patients who remained disease-free had higher levels of SOCS1 and 2 expression compared to those who died from breast cancer (p = 0.02 and p = 0.033 respectively). The disease free survival (DFS) and overall survival (OS) curves showed that higher levels of SOCS1, 3 and 7 were significant predictors of higher DFS (p = 0.015, p = 0.024 and 0.03 respectively) and OS (p = 0.005, p = 0.013 and p = 0.035 respectively). Higher levels of SOCS 4 were significant in predicting better OS (p = 0.007) but not DFS. Immunohistochemical staining of representative samples showed a correlation between SOCS1, 3, 7 protein staining and the SOCS1, 3, 7 mRNA expression.
Conclusion
Higher mRNA expression levels of SOCS1, 3, 4 and 7 are significantly associated with earlier tumour stage and better clinical outcome in human breast cancer
Complement in patients receiving maintenance hemodialysis: functional screening and quantitative analysis
<p>Abstract</p> <p>Background</p> <p>The complement system is vital for innate immunity and is implicated in the pathogenesis of inflammatory diseases and the mechanism of host defense. Complement deficiencies occasionally cause life-threatening diseases. In hemodialysis (HD) patients, profiles on complement functional activity and deficiency are still obscure. The objectives of the present study were to measure the functional complement activities of the classical pathway (CP), lectin pathway (LP) and alternative pathway (AP) using a novel method and consequently to elucidate the rates of deficiencies among HD patients.</p> <p>Methods</p> <p>In the present study, 244 HD patients at one dialysis center and 204 healthy controls were enrolled. Functional complement activities were measured simultaneously using the Wielisa<sup>®</sup>-kit. The combination of the results of these three pathway activities allows us to speculate which candidate complement is deficient; subsequently, the deficient complement was determined.</p> <p>Results</p> <p>All three functional complement activities were significantly higher in the HD patients than in the control group (P < 0.01 for all cases). After identifying candidates in both groups with complement deficiencies using the Wielisa<sup>®</sup>-kit, 16 sera (8.8%) with mannose-binding lectin (MBL) deficiency, 1 serum (0.4%) with C4 deficiency, 1 serum (0.4%) with C9 deficiency, and 1 serum (0.4%) with B deficiency were observed in the HD group, and 18 sera (8.8%) with MBL deficiency and 1 serum (0.5%) with B deficiency were observed in the control group. There were no significant differences in the 5-year mortality rate between each complement-deficient group and the complement-sufficient group among the HD patients.</p> <p>Conclusion</p> <p>This is the first report that profiles complement deficiencies by simultaneous measurement of functional activities of the three complement pathways in HD patients. Hemodialysis patients frequently suffer from infections or malignancies, but functional complement deficiencies do not confer additional risk of mortality.</p
Immune response in adverse reactions to metal debris following metal-on-metal total hip arthroplasty
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