Are the Dispossessed More Battered?

Intimate partner domestic violence hinders the well-being and development of women and transfers its ill effects intergenerationally. It is widely reported that economic fallback options help women escape intimate partner violence (IPV), enhance their ability to recuperate, and enable economic opportunity and independence. This study attempts to understand and re-examine the link between intimate partner domestic violence and the ownership of property among women in 14 districts of the Southern Indian state, Kerala. The Women Protection Officers of Kerala (WPO) served as resourceful informants. These officers are the first action force to facilitate domestic violence complaints under the Protection of Women from Domestic Violence Act, 2005 India. Primary data has been collected through interviews with WPOs. Six practising advocates shared information on the cases where they restored ownership of assets and facilitated locating the women for the twelve case studies. The findings reveal how women get dispossessed of their assets and are further subjected to domestic violence for want of assets. Women who managed to hold on to their assets were found to overcome and recuperate from domestic violence, and autonomous ownership of these assets boosted their self-esteem and recovery. The paper highlights the need for revisiting policy decisions regarding the property rights of women

Pembrolizumab for patients with non-Hodgkin lymphoma: Phase 1b KEYNOTE-013 study

The multicohort phase 1b KEYNOTE-013 study (NCT01953692) evaluated the safety and efficacy of pembrolizumab in patients with relapsed or refractory NHL who were ineligible for or failed hematopoietic cell transplantation (HCT). Patients received pembrolizumab (cohort 4) or pembrolizumab plus lenalidomide (cohort 5). Primary end points were safety and objective response rate (ORR) per IWG 2007 criteria. Cohort 4 included 89 patients. ORR was 22% (19/86; 90% CI 15-31; 10 CR, nine PR); ORRs by disease type were 48% (10/21), 10% (2/20), 12% (5/41), and 50% (2/4), for PMBCL, FL, DLBCL, and \u27other\u27 NHL, respectively. Toxicity was as predicted. Cohort 5 included 19 patients. ORR was 39% (90% CI 20-61; four CR, three PR). Hematologic toxicities were the most common treatment-related AEs. In conclusion, pembrolizumab following HCT ineligibility/failure confirms prior experience in PMBCL but not with NHL subtypes in this study. Additional analyses in DLBCL may not be warranted

Effect of clock gating in conditional pulse enhancement flip-flop for low power applications

Flip-Flops (FFs) play a fundamental role in digital designs. A clock system consumes above 25% of total system power. The use of pulse-triggered flip-flops (P-FFs) in digital design provides better performance than conventional flip-flop designs. This paper presents the design of a new power-efficient implicit pulse-triggered flip-flop suitable for low power applications. This flip-flop architecture is embedded with two key features. Firstly, the enhancement in width and height of triggering pulses during specific conditions gives a solution for the longest discharging path problem in existing P-FFs. Secondly, the clock gating concept reduces unwanted switching activities at sleep/idle mode of operation and thereby reducing dynamic power consumption. The post-layout simulation results in cadence software based on CMOS 90-nm technology shows that the proposed design features less power dissipation and better power delay performance (PDP) when compared with conventional P-FFs. Its maximum power saving against conventional designs is up to 30.65%

An analysis of the impacts of global climate and emissions changes on regional tropospheric ozone

Many of the synergistic impacts resulting from future changes in emissions as well as changes in ambient temperature, moisture, and UV flux have not been quantified. A three-dimensional regional-scale photo-chemical model (STEM-2) is used in this study to evaluate these perturbations to trace gas cycles over the eastern half of the United States of America. The model was successfully used to simulate a regional-scale ozone episode (base case - June 1984) and four perturbations scenarios - viz., perturbed emissions, temperature, water vapor column, and incoming UV flux cases, and a future scenario (for the year 2034). The impact of these perturbation scenarios on the distribution of ozone and other major pollutants such as SO2 and sulfates were analyzed in detail. The spatial distribution and the concentration of ozone at the surface increased by about 5-15 percent for most cases except for the perturbed water vapor case. The regional scale surface ozone concentration distribution for the year 2034 (future scenario) showed an increase of non-attainment areas. The rural areas of Pennsylvania, West Virginia, and Georgia showed the largest change in the surface ozone field for the futuristic scenario when compared to the base case

Impacts of Fracking on Local Ozone Pollution in DFW Area

Poster for the 2014 University of North Texas (UNT) Graduate Exhibition. This poster discusses the impacts of fracking on local ozone pollution in the Dallas-Fort Worth area

Nociceptin Signaling Involves a Calcium-Based Depolarization in Tetrahymena thermophila

Tetrahymena thermophila are free-living, ciliated eukaryotes. Their behavioral response to stimuli is well characterized and easily observable, since cells swim toward chemoattractants and avoid chemorepellents. Chemoattractant responses involve increased swim speed or a decreased change in swim direction, while chemorepellent signaling involves ciliary reversal, which causes the organism to jerk back and forth, swim in small circles, or spin in an attempt to get away from the repellent. Many food sources, such as proteins, are chemoattractants for these organisms, while a variety of compounds are repellents. Repellents in nature are thought to come from the secretions of predators or from ruptured organisms, which may serve as “danger” signals. Interestingly, several peptides involved in vertebrate pain signaling are chemorepellents in Tetrahymena, including substances P, ACTH, PACAP, VIP, and nociceptin. Here, we characterize the response of Tetrahymena thermophila to three different isoforms of nociceptin. We find that G-protein inhibitors and tyrosine kinase inhibitors do not affect nociceptin avoidance. However, the calcium chelator, EGTA, and the SERCA calcium ATPase inhibitor, thapsigargin, both inhibit nociceptin avoidance, implicating calcium in avoidance. This result is confirmed by electrophysiology studies which show that 50µM nociceptin-NH2 causes a sustained depolarization of approximately 40 mV, which is eliminated by the addition of extracellular EGTA

PACAP-38 Signaling in \u3ci\u3eTetrahymena thermophila\u3c/i\u3e Involves NO and cGMP

Chemorepellents are signaling molecules, which have been shown to be important for mammalian neuronal development, and are presumed to have a role in protozoan defense. Tetrahymena thermophila represent a good model system in which to study repellents because of their ease of use in biochemical, behavioral, electrophysiological, and genetic analyses. In this study, we have used Tetrahymena as a model in which to study the chemorepellent, PACAP. Using behavioral and biochemical (EIA) assays, we have found that the NO/cGMP pathway plays an important role in PACAP signaling. An increase in intracellular calcium is also critical for PACAP avoidance, which appears to be mediated through a pertussis toxin-sensitive G-protein

Modeling analysis of the impact of anthropogenic emission sources on ozone concentration over selected urban areas in Texas

This article discusses a regional photochemical modeling experiment set up to simulate a high ozone episode of September 11-14, 2002 to evaluate the impact of various anthropogenic emissions sources on ozone concentrations