Tubulointerstitial Nephritis and Uveitis Syndrome Associated with Renal Tryptaseand Chymase-positive Mast Cell Infiltration

We report the clinical course and immunohistochemical analysis of a patient who presented with tubulointerstitial nephritis and uveitis syndrome (TINU syndrome). The patient, a 40-year-old woman, was referred to our hospital with general fatigue and a slight fever from another hospital. Mast cells are closely related to the development of renal interstitial fibrosis in patients with glomerulonephritis. To determine the role of mast cells in renal interstitial injury in TINU patients, we performed immunohistochemical studies on renal biopsy specimens using anti-human tryptase and anti-human chymase antibodies specific for mast cells. Double immunostaining of tryptase and chymase was also performed in renal tissues. In double immunofluorescence, cells with both chymase and tryptase (MCtc) were marked in the regions of interstitial fibrosis in this patient. It appears that mast cells are one of the constitutive cells of interstitial fibrosis in patients with TINU syndrome

R&D Progress of HTS Magnet Project for Ultrahigh-field MRI

Proceedings of the 28th International Symposium on Superconductivity (ISS 2015) November 16-18, 2015, Tokyo, JapanAn R&D project on high-temperature superconducting (HTS) magnets using rare-earth Ba2Cu3O7 (REBCO) wires was started in 2013. The project objective is to investigate the feasibility of adapting REBCO magnets to ultrahigh field (UHF) magnetic resonance imaging (MRI) systems. REBCO wires are promising components for UHF-MRI magnets because of their superior superconducting and mechanical properties, which make them smaller and lighter than conventional ones. Moreover, REBCO magnets can be cooled by the conduction-cooling method, making liquid helium unnecessary. In the past two years, some test coils and model magnets have been fabricated and tested. This year is the final year of the project. The goals of the project are: (1) to generate a 9.4 T magnetic field with a small test coil, (2) to generate a homogeneous magnetic field in a 200 mm diameter spherical volume with a 1.5 T model magnet, and (3) to perform imaging with the 1.5 T model magnet. In this paper, the progress of this R&D is described. The knowledge gained through these R&D results will be reflected in the design of 9.4 T MRI magnets for brain and whole body imaging

Experiment and Simulation of Impregnated No-Insulation REBCO Pancake Coil

It is important to investigate the stability and behavior of an epoxy-resin-impregnated no-insulation (NI) REBCO pancake coil to implement high-field applications, such as ultra-high-field magnetic resonance imaging. We have performed sudden discharging and overcurrent tests for the impregnated NI REBCO pancake coil. From the discharging test, the contact resistivity is estimated, and it changes depending on the initial current. From the overcurrent test, the high thermal stability of the impregnated NI REBCO pancake coil is confirmed. The REBCO pancake coil is charged up to 67 A though the critical current is only 46 A, and no degradation has been found. To investigate in detail the electromagnetic behavior of an impregnated NI REBCO pancake coil, the simulation is performed by means of the partial element equivalent circuit (PEEC) model. In the sudden discharging test, the simulation results for the case of lower initial current are in good agreement with the experimental data. As can be inferred from the simulation results, the current drastically decreases from the inside of the impregnated NI REBCO pancake coil. The result of the overcurrent simulation is almost identical to the experimental one. However, since the contact resistivity is presumed to be constant in the simulation, the difference is observed in the high current region

A case of immunoglobulin A nephropathy with a long history (32 years) in the relatively poor prognosis group

AbstractWe report herein an immunoglobulin A nephropathy patient with a long history of 32 years in the relatively poor prognosis group according to pathological findings. In general, such cases in the relatively poor prognosis group develop end-stage renal failure, and undergo dialysis within 5 to 20 years. However, the period from the appearance of proteinuria to hemodialysis was very long in this patient. His mean blood pressure remained at approximately 100 mm Hg with the administration of some antihypertensive agent. The genotype of the angiotensin converting enzyme was II. Although normal renal function continued for the duration, he had severe acute tonsillitis at 45 and 49 years of age. After these infections, proteinuria and/or hematuria were exacerbated and he gradually progressed to end-stage renal failure. The good prognosis in this patient might be attributable to good control of blood pressure, whereas the decline in renal function might be attributable to severe recurrent upper respiratory tract infection. It seems that control of blood pressure and prevention of recurrent upper respiratory tract infection are important factors in the prognosis of patients with immunoglobulin A nephropathy. Although the association between angiotensin converting enzyme genotype and prognosis of immunoglobulin A nephropathy is controversial, it is postulated that angiotensin converting enzyme genotype II might be correlated with the good prognosis in this case

Usefulness of a Body Composition Analyzer, InBody 2.0, in Chronic Hemodialysis Patients

The objective of the present study was to investigate whether InBody 2.0 might be useful in measuring the dry weight of chronic hemodialysis (HD) patients. Thirty-five HD patients (22 males and 13 females; mean age 62.6 ± 14.0 years; mean HD duration 101.0 ± 118.06 months) were examined. Multifrequency bioelectric impedance analysis was used to estimate the ratio of extracellular water (ECW) to total body water (TBW). The body resistance was measured at frequencies ranging from 1 kHz to 1 MHz. The impedance index was determined at a low frequency (5 kHz) and correlated closely with ECW, using sodium bromide dilution as standard comparison. The levels of serum albumin, prealbumin, total cholesterol (TC), triglycerides (TG), transferrin, and human atrial natriuretic peptide (hANP) were measured by routine methods in our hospital. The ECW/TBW ratio was significantly associated with the levels of hANP (p < 0.05). However, no associations between the levels of serum albumin, TC, TG, or transferrin and the ECW/TBW were observed. It appears that the body composition analyzer, InBody 2.0, may be useful for estimating the dry weight in chronic HD patients

Project Overview of HTS Magnet for Ultra-high-field MRI System

Proceedings of the 27th International Symposium on Superconductivity (ISS 2014) November 25-27, 2014, Tokyo, JapanA project to develop an ultra-high-field magnetic resonance imaging (MRI) system based on HTS magnets using (RE)Ba2Cu3O7 (REBCO; RE=rear earth) coils is underway. The project is supported by the Japanese Ministry of Economy, Trade and Industry and aims to establish magnet technologies for a whole-body 9.4 T MRI system. REBCO wires have high critical current density in high magnetic fields and high strength against hoop stresses, and therefore, MRI magnets using REBCO coils are expected to have cryogenic systems that are smaller, lighter, and simpler than the conventional ones. A major problem in using REBCO coils for MRI magnets is the huge irregular magnetic field generated by the screening current in REBCO tapes. Thus, the main purpose of this project is to make the influence of this screening current predictable and controllable. Fundamental technologies, including treatment of the screening currents, were studied via experiments and numerical simulations using small coils. Two types of model magnets are planned to be manufactured, and the knowledge gained in the development of the model magnets will be reflected in the magnet design of a whole-body 9.4 T MRI system