Disability Decolonized: Indigenous Peoples Enacting Self-determination

Populations researched often have little if any input in the means of data collection, analysis, or authorship of the findings published. They are excluded from participating in the scientific methods even though they are the subject of the content that is being produced. This is true for Indigenous populations and the disability community around the globe. Researchers usually use colonial methodology that does not encompass the values of these communities or have their well-being in mind. This paper examines the history of colonization and how it has infiltrated science and inhibits self-determination of Indigenous peoples. Indigenous communities need to have the means and power for self-determination. For individuals with disabilities, this includes rights to services and programs that give the respect and person-centered care they deserve to make informed decisions about their lives. Moreover, there is a recognized need for culturally appropriate services that empower American Indian and Alaska Native (AI/AN) people with disabilities to lead independent lives in their own communities—urban or rural. AI/AN cultures may view disabilities differently than those in the mainstream U.S. Barriers and challenges for AI/AN individuals with intellectual and developmental disabilities (IDD) and AI/AN families of individuals with IDD in access to services include inadequate funding, personnel shortages, housing shortages, lack of coordination among agencies, lack of consultation with tribes, and problems identifying persons eligible for services. AI/AN-specific programs that have begun to bridge the gap in access to and development of culturally competent services such as Oyáte Circle and development of collegiate courses focused on AI/AN disabilities issues. There remains a need for partnership with AI/AN tribes for disability services and incorporation of AI/AN people with disabilities as equitable partners in program development and implementation. To reach a full decolonization of IDD health care and fully embrace diversity, equity, and inclusion (DEI) principles, individuals in these communities need to be viewed as experts in their journey of resilience

Atezolizumab Combined With Bevacizumab and Platinum-Based Therapy for Platinum-Sensitive Ovarian Cancer: Placebo-Controlled Randomized Phase III ATALANTE/ENGOT-ov29 Trial

Atezolizumab; Ovarian cancer; PlatinumAtezolizumab; Càncer d'ovari; PlatíAtezolizumab; Cáncer de ovario; PlatinoPURPOSE Platinum-based doublets with concurrent and maintenance bevacizumab are standard therapy for ovarian cancer (OC) relapsing after a platinum-free interval (PFI) >6 months. Immunotherapy may be synergistic with bevacizumab and chemotherapy. PATIENTS AND METHODS ATALANTE/ENGOT-ov29 (ClinicalTrials.gov identifier: NCT02891824), a placebo-controlled double-blinded randomized phase III trial, enrolled patients with recurrent epithelial OC, one to two previous chemotherapy lines, and PFI >6 months. Eligible patients were randomly assigned 2:1 to atezolizumab (1,200 mg once every 3 weeks or equivalent) or placebo for up to 24 months, combined with bevacizumab and six cycles of chemotherapy doublet, stratified by PFI, PD-L1 status, and chemotherapy regimen. Coprimary end points were investigator-assessed progression-free survival (PFS) in the intention-to-treat (ITT) and PD-L1–positive populations (alpha .025 for each population). RESULTS Between September 2016 and October 2019, 614 patients were randomly assigned: 410 to atezolizumab and 204 to placebo. Only 38% had PD-L1–positive tumors. After 3 years' median follow-up, the PFS difference between atezolizumab and placebo did not reach statistical significance in the ITT (hazard ratio [HR], 0.83; 95% CI, 0.69 to 0.99; P = .041; median 13.5 v 11.3 months, respectively) or PD-L1–positive (HR, 0.86; 95% CI, 0.63 to 1.16; P = .30; median 15.2 v 13.1 months, respectively) populations. The immature overall survival (OS) HR was 0.81 (95% CI, 0.65 to 1.01; median 35.5 v 30.6 months with atezolizumab v placebo, respectively). Global health-related quality of life did not differ between treatment arms. Grade ≥3 adverse events (AEs) occurred in 88% of atezolizumab-treated and 87% of placebo-treated patients; grade ≥3 AEs typical of immunotherapy were more common with atezolizumab (13% v 8%, respectively). CONCLUSION ATALANTE/ENGOT-ov29 did not meet its coprimary PFS objectives in the ITT or PD-L1–positive populations. OS follow-up continues. Further research on biopsy samples is warranted to decipher the immunologic landscape of late-relapsing OC

The Early Evolution of Massive Stars: Radio Recombination Line Spectra

Velocity shifts and differential broadening of radio recombination lines are used to estimate the densities and velocities of the ionized gas in several hypercompact and ultracompact HII regions. These small HII regions are thought to be at their earliest evolutionary phase and associated with the youngest massive stars. The observations suggest that these HII regions are characterized by high densities, supersonic flows and steep density gradients, consistent with accretion and outflows that would be associated with the formation of massive stars.Comment: ApJ in pres

Time Variability in Simulated Ultracompact and Hypercompact HII Regions

Ultracompact and hypercompact HII regions appear when a star with a mass larger than about 15 solar masses starts to ionize its own environment. Recent observations of time variability in these objects are one of the pieces of evidence that suggest that at least some of them harbor stars that are still accreting from an infalling neutral accretion flow that becomes ionized in its innermost part. We present an analysis of the properties of the HII regions formed in the 3D radiation-hydrodynamic simulations presented by Peters et al. as a function of time. Flickering of the HII regions is a natural outcome of this model. The radio-continuum fluxes of the simulated HII regions, as well as their flux and size variations are in agreement with the available observations. From the simulations, we estimate that a small but non-negligible fraction (~ 10 %) of observed HII regions should have detectable flux variations (larger than 10 %) on timescales of ~ 10 years, with positive variations being more likely to happen than negative variations. A novel result of these simulations is that negative flux changes do happen, in contrast to the simple expectation of ever growing HII regions. We also explore the temporal correlations between properties that are directly observed (flux and size) and other quantities like density and ionization rates.Comment: Monthly Notices of the Royal Astronomical Society, in press. The movie of free-free optical depth can be found at http://www.ita.uni-heidelberg.de/~tpeters/tau.av

Organic matter compositions and loadings in soils and sediments along the Fly River, Papua New Guinea

The compositions and loadings of organic matter in soils and sediments from a diverse range of environments along the Fly River system were determined to investigate carbon transport and sequestration in this region. Soil horizons from highland sites representative of upland sources have organic carbon contents (%OC) that range from 0.3 to 25 wt%, carbon:nitrogen ratios(OC/N) that range from 7 to 25 mol/mol, highly negative stable carbon isotopic compositions (δ¹³C[subscript org] -25 ‰) and non-woody vegetation biomarkers (cinnamyl phenols and cutin acids) more abundant relative to upper floodplain sites. Soils developed on relict Pleistocene floodplain terraces, which are typically not flooded and receive little sediment from the river, were characterized by low %OC contents ( -21 ‰) and low LP concentrations (~ 3 mg/100 mg OC). These relict floodplain soils contain modern carbon that reflects primarily local (C₃ or C₄) vegetation sources. Total suspended solids collected along the river varied widely in overall concentrations (1 > TSS > 9,000 mg/L), %OC contents (0.1 to 60 wt%), OC/N ratios (7 to 17 mol/mol) and δ¹³C[subscript org] signatures (-26 to -32 ‰). These compositions reflect a mixture of C₃ vascular plants and freshwater algae. However, little of this algal production appears to be preserved in floodplain soils. A comparison of organic carbon loadings of active floodplain soils (0.2 and 0.5 mg C/m²) with previous studies of actively depositing sediments in the adjacent delta-clinoform system (0.4 to 0.7 mg C/m²) indicates that Fly River floodplain sediments are less effective at sequestering organic carbon than deltaic sediments. Furthermore, relict Pleistocene floodplain sites with low or negligible modern sediment accumulation rates display significantly lower loadings (0.1 to 0.2 mg C/m²). This deficit in organic carbon likely reflects mineralization of sedimentary organic carbon during long term oxidative weathering, further reducing floodplain carbon storage

The Incidence of Highly-Obscured Star-Forming Regions in SINGS Galaxies

Using the new capabilities of the Spitzer Space Telescope and extensive multiwavelength data from the Spitzer Infrared Nearby Galaxies Survey (SINGS), it is now possible to study the infrared properties of star formation in nearby galaxies down to scales equivalent to large HII regions. We are therefore able to determine what fraction of large, infrared-selected star-forming regions in normal galaxies are highly obscured and address how much of the star formation we miss by relying solely on the optical portion of the spectrum. Employing a new empirical method for deriving attenuations of infrared-selected star-forming regions we investigate the statistics of obscured star formation on 500pc scales in a sample of 38 nearby galaxies. We find that the median attenuation is 1.4 magnitudes in H-alpha and that there is no evidence for a substantial sub-population of uniformly highly-obscured star-forming regions. The regions in the highly-obscured tail of the attenuation distribution (A_H-alpha > 3) make up only ~4% of the sample of nearly 1800 regions, though very embedded infrared sources on the much smaller scales and lower luminosities of compact and ultracompact HII regions are almost certainly present in greater numbers. The highly-obscured cases in our sample are generally the bright, central regions of galaxies with high overall attenuation but are not otherwise remarkable. We also find that a majority of the galaxies show decreasing radial trends in H-alpha attenuation. The small fraction of highly-obscured regions seen in this sample of normal, star-forming galaxies suggests that on 500pc scales the timescale for significant dispersal or break up of nearby, optically-thick dust clouds is short relative to the lifetime of a typical star-forming region.Comment: Accepted for publication in ApJ; emulateapj style, 30 pages, 18 figures (compressed versions), 3 table

Exile Vol. XXXVII No. 1

And It Was Sunday by Julie Gruen 1-6 Like a Lady by Grace Mulvihill 7 The Final You by Eric Franzon 8 Joseph\u27s Children by Seneca Murley 9 Ain\u27t the 1950s Anymore by Ellen Stader 10-12 Bonding Women by Shannon salser 13 Ice Man (for mami 1905-1975) by Anne Mulligan 14 The Car Salesman by Tom Ream 15 Cancelling the Bunny by Stewart Engesser 16-17 Richard Brautigan\u27s Body by Michael Payne 18-19 Dinner in Barcelona by Holly Kurtz 20 Untitled by Margaret Strachen 21 Candles by Eric Franzon 22 Summer Rules by Jim Cox 23-31 My Boat by Holly Kurtz 32 Untitled by Michael Payne 33 Half the Birds in the City by Tiffany Richardson 34-35 Down Queen Anne Hill by Julie Gruen 36-37 Your Music by Tim Emrick 38 Zephyrs by Steve Corinth 39-41 Mother by Anne Mulligan 42 As I Look to the Sky, Maize by Shannon Salser 43-45 Close Book before Striking by Sarah Verdon 46-47 Smoked by Tom Ream 48 Driving through Rain by Stewart Engesser 49-50 Contributors 51 Editorial decision is shared equally among the Editorial Board. -i 35th Yea