Extremely high data-rate, reliable network systems research

Significant progress was made over the year in the four focus areas of this research group: gigabit protocols, extensions of metropolitan protocols, parallel protocols, and distributed simulations. Two activities, a network management tool and the Carrier Sensed Multiple Access Collision Detection (CSMA/CD) protocol, have developed to the point that a patent is being applied for in the next year; a tool set for distributed simulation using the language SIMSCRIPT also has commercial potential and is to be further refined. The year's results for each of these areas are summarized and next year's activities are described

Cognitive-behavioral treatment of obsessive-compulsive disorder: A case of prolonged tooth brushing

ABSTRACT Obsessive-compulsive disorder (OCD) in children and adolescents is a prevalent condition with a number of adverse correlates and implications. The cognitive-behavioral treatment of an 11-yearold girl with prolonged tooth brushing is described in this case study. The frequency of the compulsive behavior was measured over the course of the treatment and standard assessment devices were used to determine the nature and severity of the OCD symptoms. Results of the intervention were suggestive of substantial improvements in OCD symptoms and a reduction in the associated impairments. The implications of these data were reviewed and recommendations for clinicians who intend on treating OCD in children and adolescents were provided. ARTICLE 1THEORETICAL AND RESEARCH BASI

The utility of PSMA and PSA immunohistochemistry in the cytologic diagnosis of metastatic prostate carcinoma

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107502/1/dc23075.pd

Examining Practice Patterns of Emergency Physicians through the Use of Simulated Patient Vignettes

Abstract unavailabl

Comparative Efficacy And Acceptability Of Psychotherapies For Depression In Children And Adolescents: A Systematic Review And Network Meta-Analysis

Previous meta-analyses of psychotherapies for child and adolescent depression were limited because of the small number of trials with directcomparisons between two treatments. A network meta-analysis, a novel approach that integrates direct and indirect evidence from randomizedcontrolled studies, was undertaken to investigate the comparative efficacy and acceptability of psychotherapies for depression in childrenand adolescents. Systematic searches resulted in 52 studies (total N53805) of nine psychotherapies and four control conditions. Weassessed the efficacy at post-treatment and at follow-up, as well as the acceptability (all-cause discontinuation) of psychotherapies and controlconditions. At post-treatment, only interpersonal therapy (IPT) and cognitive-behavioral therapy (CBT) were significantly more effectivethan most control conditions (standardized mean differences, SMDs ranged from -0.47 to -0.96). Also, IPT and CBT were more beneficialthan play therapy. Only psychodynamic therapy and play therapy were not significantly superior to waitlist. At follow-up, IPT and CBT weresignificantly more effective than most control conditions (SMDs ranged from -0.26 to -1.05), although only IPT retained this superiority atboth short-term and long-term follow-up. In addition, IPT and CBT were more beneficial than problem-solving therapy. Waitlist was significantlyinferior to other control conditions. With regard to acceptability, IPT and problem-solving therapy had significantly fewer all-causediscontinuations than cognitive therapy and CBT (ORs ranged from 0.06 to 0.33). These data suggest that IPT and CBT should be consideredas the best available psychotherapies for depression in children and adolescents. However, several alternative psychotherapies areunderstudied in this age group. Waitlist may inflate the effect of psychotherapies, so that psychological placebo or treatment-as-usual maybe preferable as a control condition in psychotherapy trials

Comparative Efficacy And Tolerability Of Antidepressants For Major Depressive Disorder In Children And Adolescents: A Network Meta-Analysis

Major depressive disorder is one of the most common mental disorders in children and adolescents. However, whether to use pharmacological interventions in this population and which drug should be preferred are still matters of controversy. Consequently, we aimed to compare and rank antidepressants and placebo for major depressive disorder in young people. We did a network meta-analysis to identify both direct and indirect evidence from relevant trials. We searched PubMed, the Cochrane Library, Web of Science, Embase, CINAHL, PsycINFO, LiLACS, regulatory agencies’ websites, and international registers for published and unpublished, double-blind randomised controlled trials up toMay 31, 2015, for the acute treatment of major depressive disorder in children and adolescents. We included trials of amitriptyline, citalopram, clomipramine, desipramine, duloxetine, escitalopram, fl uoxetine, imipramine, mirtazapine,nefazodone, nortriptyline, paroxetine, sertraline, and venlafaxine. Trials recruiting participants with treatmentresistantdepression, treatment duration of less than 4 weeks, or an overall sample size of less than ten patients were excluded. We extracted the relevant information from the published reports with a predefined data extraction sheet, and assessed the risk of bias with the Cochrane risk of bias tool. The primary outcomes were efficacy (change in depressive symptoms) and tolerability (discontinuations due to adverse events). We did pair-wise meta-analyses using the random-effects model and then did a random-effects network meta-analysis within a Bayesian framework. Weassessed the quality of evidence contributing to each network estimate using the GRADE framework. This study is registered with PROSPERO, number CRD42015016023

Assessment, Support, And Counseling Center

Adolescence introduces physical and psychological changes that pose a challenge to some people in this age group. The Assessment, Support, and Counseling (ASC) Center at Watauga High School is a community collaborative effort created to help fill a gap in behavioral health services provided to adolescents in the rural community of Boone, North Carolina

Depression Among College Students: Trends In Prevalence And Treatment Seeking

In a study of 182 undergraduates, a substantial proportion of the students in this sample reported significant symptoms of depression, yet only a minute number of them had ever sought treatment for their ailments. Further, the college men in this study appeared to be suffering to a greater extent than would be predicted based upon past epidemiological studies. The implications and limitations are reviewed, as are the suggestions for future research

Psychotherapy For Depression In Children And Adolescents: Study Protocol For A Systematic Review And Network Meta-Analysis

Depression is common among children and adolescents and is associated with significantly negative effects. A number of structured psychosocial treatments are administered for depression in children and adolescents; however,evidence of their effectiveness is not clear. We describe the protocol of a systematic review and network meta-analysis to evaluate the efficacy, quality of life, tolerability and acceptability of the use of psychological intervention for thisyoung population. We will search PubMed,EMBASE, CENTRAL (the Cochrane Central Register of Controlled Trials), Web of Science, PsycINFO, CINAHL, LiLACS, Dissertation Abstracts, European Association for Grey Literature Exploitation (EAGLE) and the National Technical Information Service (NTIS) from inception to July 2014. There will be no restrictions on language, publication year or publication type. Only randomised clinical trials (RCTs) with psychosocial treatments for depression in children and adolescents will be considered. The primary outcome of efficacy will be the mean overall change of the total score in continuousdepression severity scales from baseline to end point. Data will be independently extracted by two reviewers. Traditional pairwise meta–analyses will be performed for studies that directly compared different treatment arms. Then we will perform a Bayesian network meta–analyses to compare the relative efficacy, quality of life, tolerability and acceptability of different psychological intervention. Subgroup analyses will be performed by the age of participants and the duration of psychotherapy, and sensitivity analyses will be conducted to assess the robustness of the findings

The Latent Structure Of Social Anxiety Disorder And The Performance Only Specifier: A Taxometric Analysis

Social anxiety disorder (SAD) is often treated as a discrete diagnostic entity that represents a naturally occurring class, though empirical evidence largely supports a dimensional conceptualization of social fears. Further, the inclusion of a "performance only" specifier in the DSM-5 implies that individuals who experience intense social anxiety exclusively in performance situations are distinct from those with broader social fears. The purpose of the present research was to examine the latent structure of SAD and the DSM-5 "performance only" specifier in a large nonclinical sample (n = 2019). Three taxometric procedures (MAXCOV, MAMBAC, and L-Mode) were applied to indicators derived from two commonly used measures of social anxiety. Results yielded convergent evidence indicating that social anxiety exhibits a dimensional latent structure. Further, social performance anxiety demonstrates continuous relationships with milder social fears, suggesting that the "performance only" specifier may not represent a discrete entity. The implications of these findings for the assessment, diagnosis, classification, and treatment of social anxiety are discussed