Craniofacial manifestations of Loeys Dietz syndrome : A case report and a review of the literature : Case report

症例報

Orthodontic management of a patient who underwent anti-cancer therapy for acute myelogenous leukemia : A case report

Survivors of childhood cancer are at risk for disturbance of craniofacial growth and dental development as a result of the side-effects of their therapeutic protocols. For this reason, special considerations are required when oral management is planned for these children. We herein report the successful 2-stage orthodontic treatment of a girl who was diagnosed with acute myelogenous leukemia（AML） and who underwent multiple therapeutic protocols, including total body irradiation（TBI）, bone marrow transplantation（BMT）, and chemotherapy during adolescence. She showed skeletal Class III malocclusion with a low mandibular plane angle, anterior crossbite, crowding, and severely disturbed dental development, including tooth agenesis, and arrested root development, and enamel hypoplasia at 12 years of age, when she first visited our clinic. Growth modification in adolescence period with functional appliances followed by treatment with a fixed appliance was performed to correct her malocclusion. The aim of this case report is to show the long-term outcome of orthodontic treatment in a patient who underwent multiple anticancer therapies that influenced craniofacial growth and dental development.症例報

Immune State Conversion of the Mesenteric Lymph Node in a Mouse Breast Cancer Model

Secondary lymphoid tissues, such as the spleen and lymph nodes (LNs), contribute to breast cancer development and metastasis in both anti- and pro-tumoral directions. Although secondary lymphoid tissues have been extensively studied, very little is known about the immune conversion in mesenteric LNs (mLNs) during breast cancer development. Here, we demonstrate inflammatory immune conversion of mLNs in a metastatic 4T1 breast cancer model. Splenic T cells were significantly decreased and continuously suppressed IFN-gamma production during tumor development, while myeloid-derived suppressor cells (MDSCs) were dramatically enriched. However, T cell numbers in the mLN did not decrease, and the MDSCs only moderately increased. T cells in the mLN exhibited conversion from a pro-inflammatory state with high IFN-gamma expression to an anti-inflammatory state with high expression of IL-4 and IL-10 in early- to late-stages of breast cancer development. Interestingly, increased migration of CD103(+)CD11b(+) dendritic cells (DCs) into the mLN, along with increased (1 -> 3)-beta-D-glucan levels in serum, was observed even in late-stage breast cancer. This suggests that CD103(+)CD11b(+) DCs could prime cancer-reactive T cells. Together, the data indicate that the mLN is an important lymphoid tissue contributing to breast cancer development

The usefulness of a new gait symmetry parameter derived from Lissajous figures of tri-axial acceleration signals of the trunk

textabstractThis cross-country study adopts a competing theories approach in which both a value perspective and a social capital perspective are used to understand the relation between religion and a country’s business ownership rate. We distinguish among four dimensions of religion: belonging to a religious denomination, believing certain religious propositions, bonding to religious practices, and behaving in a religious manner. An empirical analysis of data from 30 OECD countries with multiple data points per country covering the period 1984–2010 suggests a positive relationship between religion and business ownership based on those dimensions that reflect the internal aspects of religiosity (i.e., believing and behaving). We do not observe a significant association for those dimensions that reflect more external aspects of religion (i.e., belonging and bonding). These results suggest that the social capital perspective prevails the value perspective, at least when internal aspects of religiosity are concerned. More generally, our study demonstrates the importance of distinguishing between different dimensions of religion when investigating the link between religion and entrepreneurship

The Roles of Hedgehog Signaling in Upper Lip Formation

Craniofacial development consists of a highly complex sequence of the orchestrated growth and fusion of facial processes. It is also known that craniofacial abnormalities can be detected in 1/3 of all patients with congenital diseases. Within the various craniofacial abnormalities, orofacial clefting is one of the most common phenotypic outcomes associated with retarded facial growth or fusion. Cleft lip is one of the representative and frequently encountered conditions in the spectrum of orofacial clefting. Despite various mechanisms or signaling pathways that have been proposed to be the cause of cleft lip, a detailed mechanism that bridges individual signaling pathways to the cleft lip is still elusive. Shh signaling is indispensable for normal embryonic development, and disruption can result in a wide spectrum of craniofacial disorders, including cleft lip. This review focuses on the current knowledge about the mechanisms of facial development and the etiology of cleft lip that are related to Shh signaling