Inubushi, Toshihiro

Kikuchi, Masataka

Koga, Satoshi

Kurosaka, Hiroshi

Mithun, Saha

Mushiake, Jin

Nakaya, Akihiro

Sandell, Lisa L.

Trainor, Paul

Wang, Qi

Wu, Yanran

Yamamoto, Sayuri

Yamashiro, Takashi

English

Developmental defects of primitive choanae, an anatomical path to connect the embryonic nasal and oral cavity, result in disorders called choanal atresia, which are associated with many congenital diseases and require immediate clinical intervention after birth. Previous studies revealed that reduced retinoid signaling underlies the etiology of choanal atresia. In the present study, by using multiple mouse models which conditionally deleted Rdh10 and Gata3 during embryogenesis, we showed that Gata3 expression is regulated by retinoid signaling during embryonic craniofacial development and plays crucial roles for development of the primitive choanae. Interestingly, Gata3 loss of function is known to cause hypoparathyroidism, sensorineural deafness and renal disease (HDR) syndrome, which exhibits choanal atresia as one of the phenotypes in humans. Our model partially phenocopies HDR syndrome with choanal atresia, and is thus a useful tool for investigating the molecular and cellular mechanisms of HDR syndrome. We further uncovered critical synergy of Gata3 and retinoid signaling during embryonic development, which will shed light on novel molecular and cellular etiology of congenital defects in primitive choanae formation

Osaka University Knowledge Archive

Synergistic role of retinoic acid signaling and Gata3 during primitive choanae formation

https://ir.library.osaka-u.ac.jp/repo/ouka/all/79001/HumMolGenet_2021.pdf

Synergistic role of retinoic acid signaling and Gata3 during primitive choanae formation

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