Non-uniform distribution of the contraction/extension (C–E) in the left ventricular myocardium related to the myocardial function

AbstractObjectiveWe attempted to disclose the microscopic characteristics of the non-uniform distribution of the contraction and extension (C–E) of the left ventricular (LV) myocardium using a new methodology (echo-dynamography).MethodsThe distributions of the “axial strain rate” (aSR) and the intra-mural velocity in the local areas of the free wall including the posterior wall (PW) and interventricular septum (IVS) were microscopically obtained using echo-dynamography with a high accuracy of 821μm in the spatial resolution. The results were shown by the color M-mode echocardiogram or curvilinear graph. Subjects were 10 presumably normal volunteers.Results(1)Both the C–E in the pulsating LV wall showed non-uniformity spatially and time-sequentially.(2)The C–E property was better evaluated by the aSR distribution method rather than the intra-mural velocity distribution method.(3)Two types of non-uniformity of the aSR distribution were observed: i.e. (i) the difference of its (+)SR (contraction: C) or (−)SR (extension: E) was solely the “magnitude”; (ii) the coexistence of both the (+) SR and (−)SR at the same time.(4)The aSR distribution during systole was either “spotted,” or “multi-layered,” or “toned” distribution, whereas “stratified,” “toned,” or “alternating” distributions were observed during diastole.(5)The aSR distribution in the longitudinal section plane was varied in the individual areas of the wall even during the same timing.(6)To the mechanical function of the LV, there was a different behavior between the IVS and PW.ConclusionsThe aSR and its distribution were the major determinants of the C–E property of the LV myocardium. Spatial as well as time-sequential uniformity of either contraction or extension did not exist. The myocardial function changed depending on the assemblage of the aSR distribution, and by the synergistic effect of (+)SR and (−)SR, the non-uniformity itself potentially served to hold the smooth LV mechanical function

Phospholipase Cδ4 is required for Ca2+ mobilization essential for acrosome reaction in sperm

Zona pellucida (ZP)–induced acrosome reaction in sperm is a required step for mammalian fertilization. However, the precise mechanism of the acrosome reaction remains unclear. We previously reported that PLCδ4 is involved in the ZP-induced acrosome reaction in mouse sperm. Here we have monitored Ca2+ responses in single sperm, and we report that the [Ca2+]i increase in response to ZP, which is essential for driving the acrosome reaction in vivo, is absent in PLCδ4−/− sperm. Progesterone, another physiological inducer of the acrosome reaction, failed to induce sustained [Ca2+]i increases in PLCδ4−/− sperm, and consequently the acrosome reaction was partially inhibited. In addition, we observed oscillatory [Ca2+]i increases in wild-type sperm in response to these acrosome inducers. Calcium imaging studies revealed that the [Ca2+]i increases induced by exposure to ZP and progesterone started at different sites within the sperm head, indicating that these agonists induce the acrosome reaction via different Ca2+ mechanisms. Furthermore, store-operated channel (SOC) activity was severely impaired in PLCδ4−/− sperm. These results indicate that PLCδ4 is an important enzyme for intracellular [Ca2+]i mobilization in the ZP-induced acrosome reaction and for sustained [Ca2+]i increases through SOC induced by ZP and progesterone in sperm

Critical current for phase shift of dry-band discharge on wet polluted insulators

This paper presents experimental results on the influence of the electrolyte on the phase shift of dry-band discharges. Twotypes of electrolytes (NaCl and MgCl2) were introduced to compare the case of KCl, and a model electrode system including glassfilterelectrodes wetted with an aqueous solution of the electrolyte was employed to simulate a dry band. The spectral emissionintensity originated from the electrolyte depended on the electrolyte and was strongly affected by the peak value of the currentduring the continuous dry-band discharge. Finaly, the critical current was found to be approximately 3 mA irrespective of theelectrolytes examined

GREX-PLUS Science Book

GREX-PLUS (Galaxy Reionization EXplorer and PLanetary Universe Spectrometer) is a mission candidate for a JAXA's strategic L-class mission to be launched in the 2030s. Its primary sciences are two-fold: galaxy formation and evolution and planetary system formation and evolution. The GREX-PLUS spacecraft will carry a 1.2 m primary mirror aperture telescope cooled down to 50 K. The two science instruments will be onboard: a wide-field camera in the 2-8 $\mu$m wavelength band and a high resolution spectrometer with a wavelength resolution of 30,000 in the 10-18 $\mu$m band. The GREX-PLUS wide-field camera aims to detect the first generation of galaxies at redshift $z>15$. The GREX-PLUS high resolution spectrometer aims to identify the location of the water ``snow line'' in proto-planetary disks. Both instruments will provide unique data sets for a broad range of scientific topics including galaxy mass assembly, origin of supermassive blackholes, infrared background radiation, molecular spectroscopy in the interstellar medium, transit spectroscopy for exoplanet atmosphere, planetary atmosphere in the Solar system, and so on