Hepatocyte growth factor prevents lupus nephritis in a murine lupus model of chronic graft-versus-host disease

Chronic graft-versus-host disease (GVHD) induced in (C57BL/6 × DBA/2) F1 (BDF1) mice by the injection of DBA/2 mouse spleen cells represents histopathological changes associated with systemic lupus erythematosus (SLE), primary biliary cirrhosis (PBC) and Sjogren's syndrome (SS), as indicated by glomerulonephritis, lymphocyte infiltration into the periportal area of the liver and salivary glands. We determined the therapeutic effect of hepatocyte growth factor (HGF) gene transfection on lupus using this chronic GVHD model. Chronic GVHD mice were injected in the gluteal muscle with either HVJ liposomes containing 8 μg of the human HGF expression vector (HGF-HVJ liposomes) or mock vector (untreated control). Gene transfer was repeated at 2-week intervals during 12 weeks. HGF gene transfection effectively prevented the proteinuria and histopathological changes associated with glomerulonephritis. While liver and salivary gland sections from untreated GVHD mice showed prominent PBC- and SS-like changes, HGF gene transfection reduced these histopathological changes. HGF gene transfection greatly reduced the number of splenic B cells, host B cell major histocompatibility complex class II expression, and serum levels of IgG and anti-DNA antibodies. IL-4 mRNA expression in the spleen, liver, and kidneys was significantly decreased by HGF gene transfection. CD28 expression on DBA/2 CD4+ T cells was decreased by the addition of recombinant HGF in vitro. Furthermore, IL-4 production by DBA/2 CD4+ T cells stimulated by irradiated BDF1 dendritic cells was significantly inhibited by the addition of recombinant HGF in vitro. These results suggest that HGF gene transfection inhibited T helper 2 immune responses and reduced lupus nephritis, autoimmune sialoadenitis, and cholangitis in chronic GVHD mice. HGF may represent a novel strategy for the treatment of SLE, SS and PBC

Practical study on a new type Buckling-Restrained-Brace

p. 303-311A number of a new type Buckling-Restrained-Brace (T-BRB) using steel mortar planks have been applied to various structures (spatial structures, steel bridges and steel towers) as well as multi-story buildings. The brace has two buckling restraining parts (steel mortar planks), clipping a core plate being under axial forces. These parts are welded together and restrain the core plate of plastic behavior, avoiding the out-of-plane deformation and the buckling. The size of steel mortar plank can be designed corresponding to energy absorption demands, irrespectively the sizes of both end-connections. This paper introduces the applications of a new type BRB to various structures.Oya, T.; Fukasawa, T.; Fujiwara, M.; Kuroiwa, Y.; Arai, J. (2009). Practical study on a new type Buckling-Restrained-Brace. Editorial Universitat Politècnica de València. http://hdl.handle.net/10251/652

6自由度顎運動測定装置の試用

The purpose of this study was to quantitatively analyze the mandibular movement by the Jaw tracking system with six degree of freedom (MM-JI-E). Displacements of the condyles under maximum clenching with successive loss of mandibular supporting zones were measured. The patient, a 29-year-old man, had been treated at an orthodontic clinic between 1994 and 1997, and temporary full coverage crowns were fabricated on four molars of the lower jaw. He showed no signs of abnormality of stomatognathic function. We measured the jaw movements with MM-JI-E, removing the crowns from the distal end of molars to the mesial. The condylar displacement values were displayed and calculated by the measurement of mandibular movement. When the supporting zones were reduced successively, both condyles moved upwards and slightly forwards (87-117°). The maximal condylar displacement values was 700μm without any support in the molars. We compared the measurements of MM-JI-E with those obtained with another jaw movement tracking system (Bio Pack), with three degree of freedom. The maximum opening paths in sagittal border movement were compared for the two measurement systems. The Bio Pack showed the deflection of the path of anterior maximum opening due to electronic error

純チタンの鋳造性に関する研究(第4報)通気性の低い鋳型への鋳造

The purpose of this study was to evaluate the influence of casting molds with low permeability on the castability of pure titanium with an all directional pressured type casting machine. Two types of phosphate bonded casting molds were used, T-INVEST and T-INVEST C&B. We reported high performance of castability of pure titanium with an all directional pressured type casting machine, if the permeability of the investment was lower as possible. Specially prepared metal sealed rings to decrease gas permeability of casting mold were used. Two sizes of sprue condition were prepared, 1.26 and 1.48mm, under a casting pressure of 8kgf/cm^2. Five sizes of casting molds were prepared with mold diameters of 25, 35,45,55 and 65mm. The following results were obtained: A high percentage of castability was gained in T-INVEST using a high gas permeability casting mold with the sealed ring. A low percentage of castability was gained in T-INVEST C&B using a low gas permeability casting mold with the sealed ring. Back pressure action in the casting mold of T-INVEST C&B seemed to produce negative effects regarding the castability. These results indicated that the sealed ring was effective to promote pure titanium castability with a mold of high permeability

純チタンの鋳造性に関する研究(第3報)鋳造圧およびスプルー径がチタンの鋳込率に及ぼす影響について

We analyzed the external defects of castings with mesh grid patterns with 3 different kinds of phosphate bonded casting molds with 2 parameters (sprue diameter and casting pressure). Castability with pure titanium was affected by the parameters of sprue diameter, and casting pressure with different casting molds. The sprue condition was the most affective casting condition in the all directional pressure type casting machine. In 2 types of casting molds, one was strongly affected by the casting pressure in castability and the other was scarcely affected by the casting pressure. The former type of casting mold had a low permeability

チタン鋳造における鋳型温度の影響

The purpose of this study was to evaluate the titanium castability with a vacuum pressured type casting machine. We tested ethyl-silicate bonded investment "TITAVESTPS" of metal frame work. Four different mold temperatures (room temperature, 300℃, 600℃, and 900℃) were prepared for the present study, and casting was done in five times in each condition. When the mold temperature increased, high percentage of castability was gained. Mold temperature showed a highly significant (p<0.001) correlation on the castability. These results indicate that high performance of castability on the titanium was achieved when the mold temperature increased by using vacuum pressured type casting machine

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

Evaluation of defibrillation safety and shock reduction in implantable cardioverter-defibrillator patients with increased time to detection: A randomized SANKS study

Background: The need for ways to minimize the number of implantable cardioverter-defibrillator (ICD) shocks is increasing owing to the risk of its adverse effects on life expectancy. Studies have shown that a longer detection time for ventricular tachyarrhythmia reduces the safety of therapies, in terms of syncope and mortality, but not substantially in terms of the success rate. We aimed to evaluate the effects of increased number of intervals to detect (NID) VF on the safety of ICD shock therapy and on the reduction of inappropriate shocks. Methods: The present study was a prospective, multicenter, randomized, crossover study. Randomized VF induction testing with NID 18/24 or 30/40 was performed to compare the success rate of defibrillation with a 25-J shock and the time to detection. Inappropriate shock episodes were simulated retrospectively to evaluate a possibility of episodes avoidable at NID 24/32 and 30/40. Results: Thirty-one consecutive patients implanted with an ICD or cardiac resynchronization therapy-defibrillator (CRT-D) were enrolled in this study. The success rate of defibrillation was 100% in both NID groups at the first shock. The time from VF induction to detection showed a significant increase in the NID 30/40 group (6.16±1.29 s vs. 9.00±1.31 s, p<0.001). Among the 120 patients implanted with an ICD or CRT-D, 10 experienced 32 inappropriate shock episodes. The inappropriate shock reduction rate was 53.1% and 62.5% with NID 24/32 and 30/40, respectively. Conclusions: The findings of this SANKS study suggest that VF NID 30/40 does not compromise the safety of ICD shock therapy, while decreasing the number of inappropriate shocks