La Patrie : journal quotidien, politique, commercial et littéraire

05 janvier 19141914/01/05 (A74)

Experience with Lavacol in the treatment of chronic constipation

The article tells about intermediate results of a comparative study of the efficacy and tolerability of Lavacol® in the treatment of chronic constipation. The treatment group consisted of patients receiving Lavacol®, and the control group included patients after treatment with Forlax. Comparison of findings obtained before treatment and within the same periods from the beginning of treatment, showed no significant difference between the groups. The results demonstrated high efficacy and safety of Lavacol® similar to that of Forlax for the symptomatic treatment of constipation in patients with functional constipation and constipation-predominant irritable bowel syndrome (in accordance with Rome III criteria)

Pantoprazole niche among the GERD-medicines

Main groups of antisecretory drugs used in the treatment of acid-dependent diseases, including gastroesophageal reflux disease (GERD), are described in a review. Mechanisms of activation, degradation and inactive metabolites formation of proton pump inhibitors (PPIs) – final elements of acid production blockage – are considered in detail. Special attention is paid to the presence of PPIs’ derivatives with different functional activity: inactive derivatives, active and inactive metabolites. Topographic description of these derivatives, their significance in terms of an effect on bioavailability, clinical effectiveness and a potential of PPIs interactions with other administered drugs. The combined decision-making algorithm in the presence of gastroesophageal reflux disease symptoms is presented, compiled on the basis of the most authoritative current recommendations. This algorithm provides for the use of PPIs in standard doses once a day for 4–8 weeks with a possible dose escalation in a case of ineffectiveness. If treatment with high doses of PPIs is ineffective, a set of measures is needed to identify the causes of this inefficiency and to choose additional medical strategy. Depending on the clinical situation, after erosions epithelization the treatment can be stopped, used on demand, prolonged in the intermittent or supportive forms. Particular attention is paid to the Panum® drug, which has proven its effectiveness in patients with different degrees of reflux esophagitis. The availability of dosage forms for prescription and over-the-counter leave allows ensuring its comfortable and unhindered purchase by patients and eliminating excessive burden on the healthcare system

CYCLIC FEEDING REGIMEN AND OXIDATIVE STRESS IN HEPATOCYTE NUCLEI OF YOUNG AND OLD RATS

The effect of cyclic feeding regimen on the dynamics of oxidative stress in hepatocyte nuclei of 3- and 19-month rats has been investigated. The intensity of pro-oxidative processes was evaluated by measuring of TBARs content. The most pronounced oxidative stress was found to occur in young animals only after first cycle of periodic starvation/body weight recovery. The decrease in the intensity of oxidative processes observed in the course of the second cycle of dietary restriction was interpreted as arising from adaptive mechanisms