4 research outputs found
Prevalence of hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) in the population of adult asthmatics in Poland based on an epidemiological questionnaire
Introduction: Hypersensitivity reactions to drugs account for 25% of all side effects related to drugs, affecting more than 7%
of the population. One in four such reactions is caused by acetylic acid and other non-steroidal anti-inflammatory drugs.
Material and methods: Between 1998 and 2000 epidemiological research was carried out in various centers, with the aim of
estimating the frequency of allergy-based diseases in Poland. The objective of the study was to evaluate the frequency of hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs), based on an epidemiological questionnaire, in the Polish adult population.
Results: Bronchial asthma was diagnosed in 582 patients (5.4%). Of that group, 75 patients (12.9%) additionally reported
symptoms of hypersensitivity to NSAIDs. Aspirin-induced asthma was diagnosed in 11 patients (14.7%) with clinical
manifestations of hypersensitivity responses. Frequency of aspirin-induced asthma with clinical symptoms amounted to
1.9% of asthmatics. In the assessment of severity of the disease, aspirin intolerance was the only statistically significant
factor (p = 0.0003; odds ratio 28.6 with assumed 95% confidence interval).
Conclusions: In the population of adults in Poland, the frequency of aspirin-induced asthma amounted to 0.1%. Hypersensitivity to NSAIDs was observed in 12.9% of asthmatics. In asthmatics with symptoms of hypersensitivity to non-steroidal
anti-inflammatory drugs, which takes the course of clinically demonstrable aspirin-induced asthma, the risk of severe
asthma is 30-fold higher
Prevalence of hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) in the population of adult asthmatics in Poland based on an epidemiological questionnaire
Wst臋p: Reakcje nadwra偶liwo艣ci na leki stanowi膮 oko艂o 25% dzia艂a艅 niepo偶膮danych lek贸w i dotycz膮 ponad 7% og贸lnej
populacji. Kwas acetylosalicylowy i inne niesteroidowe leki przeciwzapalne (NLPZ) w jednej czwartej przypadk贸w odpowiadaj膮
za te reakcje.
Materia艂 i metody: W latach 1998–2000 przeprowadzono wieloo艣rodkowe badanie epidemiologiczne, maj膮ce oszacowa膰
cz臋sto艣膰 wyst臋powania schorze艅 alergicznych w Polsce. Celem autor贸w pracy by艂a pr贸ba oceny cz臋sto艣ci wyst臋powania
reakcji nadwra偶liwo艣ci na NLPZ w populacji doros艂ych cierpi膮cych na astm臋 w Polsce, na podstawie prowadzonych bada艅
epidemiologicznych.
Wyniki: Badanie obj臋艂o grup臋 10 684 doros艂ych os贸b w Polsce. Astm臋 oskrzelow膮 rozpoznano u 582 (5,4%) badanej populacji.
W grupie tej 75 chorych (12,9%) zg艂asza艂o objawy nadwra偶liwo艣ci na NLPZ. Cz臋sto艣膰 wyst臋powania astmy aspirynowej
wynios艂a 1,9% w艣r贸d wszystkich chorych na astm臋. W grupie z nadwra偶liwo艣ci膮 na NLPZ astm臋 przewlek艂膮 umiarkowan膮 choi
ci臋偶k膮 rozpoznano u 21,3% chorych. W ocenie ci臋偶ko艣ci astmy w艣r贸d populacji badanej istotno艣膰 statystyczn膮 uzyskano
w tylko w przypadku nietolerancji na aspiryn臋 (p = 0,0003; iloraz szans 28,6 przy za艂o偶onym 95-procentowym przedziale
ufno艣ci).
Wnioski: Cz臋sto艣膰 wyst臋powania astmy aspirynowej w populacji os贸b doros艂ych w Polsce wynosi 0,1%, natomiast w艣r贸d
doros艂ych chorych na astm臋 oskrzelow膮 stanowi 1,9%. Reakcje nadwra偶liwo艣ci na NLPZ wyst臋puj膮 u 12,9% doros艂ych
chorych na astm臋 w Polsce. Chorych na astm臋 aspirynow膮 charakteryzuje statystycznie znamiennie ci臋偶szy przebieg choroby
w por贸wnaniu do chorych na astm臋 toleruj膮cych aspiryn臋. Ryzyko wyst膮pienia u nich ci臋偶kiego przebiegu astmy jest
zwi臋kszone blisko 30-krotnie.Introduction: Hypersensitivity reactions to drugs account for 25% of all side effects related to drugs, affecting more than 7%
of the population. One in four such reactions is caused by acetylic acid and other non-steroidal anti-inflammatory drugs.
Material and methods: Between 1998 and 2000 epidemiological research was carried out in various centers, with the aim of
estimating the frequency of allergy-based diseases in Poland. The objective of the study was to evaluate the frequency of hypersensitivity
to non-steroidal anti-inflammatory drugs (NSAIDs), based on an epidemiological questionnaire, in the Polish adult population.
Results: Bronchial asthma was diagnosed in 582 patients (5.4%). Of that group, 75 patients (12.9%) additionally reported
symptoms of hypersensitivity to NSAIDs. Aspirin-induced asthma was diagnosed in 11 patients (14.7%) with clinical
manifestations of hypersensitivity responses. Frequency of aspirin-induced asthma with clinical symptoms amounted to
1.9% of asthmatics. In the assessment of severity of the disease, aspirin intolerance was the only statistically significant
factor (p = 0.0003; odds ratio 28.6 with assumed 95% confidence interval).
Conclusions: In the population of adults in Poland, the frequency of aspirin-induced asthma amounted to 0.1%. Hypersensitivity
to NSAIDs was observed in 12.9% of asthmatics. In asthmatics with symptoms of hypersensitivity to non-steroidal
anti-inflammatory drugs, which takes the course of clinically demonstrable aspirin-induced asthma, the risk of severe
asthma is 30-fold higher