Long-Term Neurodevelopmental Outcome of Monochorionic and Matched Dichorionic Twins

Contains fulltext : 79941.pdf (publisher's version ) (Open Access)BACKGROUND: Monochorionic (MC) twins are at increased risk for perinatal mortality and serious morbidity due to the presence of placental vascular anastomoses. Cerebral injury can be secondary to haemodynamic and hematological disorders during pregnancy (especially twin-to-twin transfusion syndrome (TTTS) or intrauterine co-twin death) or from postnatal injury associated with prematurity and low birth weight, common complications in twin pregnancies. We investigated neurodevelopmental outcome in MC and dichorionic (DC) twins at the age of two years. METHODS: This was a prospective cohort study. Cerebral palsy (CP) was studied in 182 MC infants and 189 DC infants matched for weight and age at delivery, gender, ethnicity of the mother and study center. After losses to follow-up, 282 of the 366 infants without CP were available to be tested with the Griffiths Mental Developmental Scales at 22 months corrected age, all born between January 2005 and January 2006 in nine perinatal centers in The Netherlands. Due to phenotypic (un)alikeness in mono-or dizygosity, the principal investigator was not blinded to chorionic status; perinatal outcome, with exception of co-twin death, was not known to the examiner. FINDINGS: Four out of 182 MC infants had CP (2.2%) - two of the four CP-cases were due to complications specific to MC twin pregnancies (TTTS and co-twin death) and the other two cases of CP were the result of cystic PVL after preterm birth - compared to one sibling of a DC twin (0.5%; OR 4.2, 95% CI 0.5-38.2) of unknown origin. Follow-up rate of neurodevelopmental outcome by Griffith's test was 76%. The majority of 2-year-old twins had normal developmental status. There were no significant differences between MC and DC twins. One MC infant (0.7%) had a developmental delay compared to 6 DC infants (4.2%; OR 0.2, 95% 0.0-1.4). Birth weight discordancy did not influence long-term outcome, though the smaller twin had slightly lower developmental scores than its larger co-twin. CONCLUSIONS: There were no significant differences in occurrence of cerebral palsy as well as neurodevelopmental outcome between MC and DC twins. Outcome of MC twins seems favourable in the absence of TTTS or co-twin death

Fatores associados ao desenvolvimento mental e motor de crianças de quatro creches públicas de Recife, Brasil Factors associated with mental and psychomotor development of infants in four public day care centers in the municipality of Recife, Brazil

OBJETIVO: Identificar os fatores associados aos índices de desenvolvimento mental e motor em lactentes que frequentam creches da rede municipal em Recife. MÉTODOS: Estudo de corte transversal realizado entre fevereiro e abril de 2005 em uma amostra de 108 crianças com idade entre quatro e 24 meses, pertencentes a quatro creches municipais do Recife. O desenvolvimento mental e motor foi avaliado pela Escala de Desenvolvimento Infantil de Bayley II. Por meio de entrevistas às mães, foram obtidas informações sobre as condições socioeconômicas e demográficas das famílias e as características biológicas das crianças ao nascer (peso, sexo e idade gestacional). O estado nutricional foi avaliado através dos índices peso/idade, comprimento/idade, peso/comprimento e da concentração de hemoglobina. RESULTADOS: As médias dos índices de desenvolvimento mental e motor foram 88±11 e 95±12 pontos, respectivamente. A idade gestacional apresentou associação significativa com o desenvolvimento mental e motor e o peso ao nascer e o estado nutricional atual, avaliado pelo índice peso/comprimento, se associaram ao desenvolvimento motor. CONCLUSÕES: As crianças analisadas apresentaram desenvolvimento neuropsicomotor ainda na faixa de normalidade, mas aquém do esperado para a idade, comparado a populações de referência em países desenvolvidos. Os fatores associados ao baixo desempenho do desenvolvimento nessa população estão relacionados aos fatores biológicos, destacando-se os déficits nutricionais, cuja redução deve ser uma prioridade para gestores em saúde e educação.<br>OBJECTIVE: To identify factors associated with mental and psychomotor development of infants enrolled at public day care centers of Recife, Pernambuco, Brazil. METHODS: This is a cross-sectional study conducted with 108 infants aged four to 24 months attending four public day care centers of the Municipality of Recife from February to April 2005. Mental and psychomotor development was assessed by the Bayley Scale of Infant Development II. Family socioeconomic and demographic conditions and infant biological characteristics at birth (weight, sex and gestational age) were obtained by maternal interview. Nutritional status was assessed by the indexes "weight-for-age", "length-for-age" and "weight-for-length" and by hemoglobin level. RESULTS: Mean mental and psychomotor development indexes were 88±11 and 95±12, respectively. Gestational age showed significant association with mental and psychomotor development. Birthweight and current nutritional status assessed by "weight-for-length" were associated with psychomotor development. CONCLUSIONS: Mental and psychomotor development were in the the normal range, but, below the expected for infants of the same age group of reference populations in developed countries. The factors associated with poor developmental indexes in this population are related to biological factors, with emphasis on nutritional deficits. Their reduction should be a priority for health and educational policy managers