Council on East Asian Libraries Statistics 2005-2006 For North American Institutions

Council on East Asian Libraries (CEAL) 2005-2006 annual statistical data. Data collected include volumes held, volumes added gross, serials, e-journals, other materials, electronic resources, expenditures, staffing, and user services.CEAL Statistics (Council on East Asian Libraries

Council on East Asian Libraries Statistics 2004-2005

Council on East Asian Libraries (CEAL) 2004-2005 annual statistical data. Data collected include volumes held, volumes added gross, serials, e-journals, other materials, electronic resources, expenditures, staffing, and user services.CEAL Statistics (Council on East Asian Libraries

Council on East Asian Libraries Statistics 2006-2007 For North American Institutions

ouncil on East Asian Libraries (CEAL) 2006-2007 annual statistical data. Data collected include volumes held, volumes added gross, serials, e-journals, other materials, electronic resources, expenditures, staffing, and user services.CEAL Statistics (Council on East Asian Libraries

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

AbstractBackground: Fas (APO-1/CD95) is a member of the tumor necrosis factor receptor (TNF-R) family and induces apoptosis when crosslinked with either Fas ligand or agonistic antibody (Fas antibody). The Fas–Fas ligand system has an important role in the immune system where it is involved in the downregulation of immune responses and the deletion of peripheral autoreactive T lymphocytes. The intracellular domain of Fas interacts with several proteins including FADD (MORT-1), DAXX, RIP, FAF-1, FAP-1 and Sentrin. The adaptor protein FADD can, in turn, interact with the cysteine protease caspase-8 (FLICE/MACH/Mch5).Results: In a genetic screen for essential components of the Fas-mediated apoptotic cascade, we isolated a Jurkat T lymphocyte cell line deficient in caspase-8 that was completely resistant to Fas-induced apoptosis. Complementation of this cell line with wild-type caspase-8 restored Fas-mediated apoptosis. Fas activation of multiple caspases and of the stress kinases p38 and c-Jun NH2-terminal kinase (JNK) was completely blocked in the caspase-8-deficient cell line. Furthermore, the cell line was severely deficient in cell death induced by TNF-α and was partially deficient in cell death induced by ultraviolet irradiation, adriamycin and etoposide.Conclusions: This study provides the first genetic evidence that caspase-8 occupies an essential and apical position in the Fas signaling pathway and suggests that caspase-8 may participate broadly in multiple apoptotic pathways

On-Field Deployment and Validation for Wearable Devices

Wearable sensors are an important tool in the study of head acceleration events and head impact injuries in sporting and military activities. Recent advances in sensor technology have improved our understanding of head kinematics during on-field activities; however, proper utilization and interpretation of data from wearable devices requires careful implementation of best practices. The objective of this paper is to summarize minimum requirements and best practices for on-field deployment of wearable devices for the measurement of head acceleration events in vivo to ensure data evaluated are representative of real events and limitations are accurately defined. Best practices covered in this document include the definition of a verified head acceleration event, data windowing, video verification, advanced post-processing techniques, and on-field logistics, as determined through review of the literature and expert opinion. Careful use of best practices, with accurate acknowledgement of limitations, will allow research teams to ensure data evaluated is representative of real events, will improve the robustness of head acceleration event exposure studies, and generally improve the quality and validity of research into head impact injuries