1,033 research outputs found
Immunoadsorption of agonistic autoantibodies against α1-adrenergic receptors in patients with mild to moderate dementia
Dementia has been shown to be associated with agonistic autoantibodies. The deleterious action of autoantibodies on the {alpha}1-adrenergic receptor for brain vasculature has been demonstrated in animal studies. In the current study, 169 patients with dementia were screened for the presence of agonistic autoantibodies. 47% of patients suffering from mild to moderate Alzheimer's disease and/or vascular dementia carried these autoantibodies. Eight patients positive for autoantibodies underwent immunoadsorption. Patients treated on four consecutive days were subsequently negative for autoantibodies and displayed stabilization of cognitive and mental condition during 12-18 months' follow-up. In patients treated for 2-3 days, autoantibodies were reduced by only 78%. They suffered a rebound of autoantibodies during follow-up, benefited from immunoadsorption too, but their mental parameters worsened. We provide first data on the clinical relevance of agonistic autoantibodies in dementia and show that immunoadsorption is safe and efficient in removing autoantibodies with overall benefits for patients
Modeling the Transport and Deposition of ¹⁰Be Produced by the Strongest Solar Proton Event During the Holocene
Prominent excursions in the number of cosmogenic nuclides (e.g., ¹⁰Be) around 774 CE/775 document the most severe solar proton event (SPE) throughout the Holocene. Its manifestation in ice cores is valuable for geochronology, but also for solar-terrestrial physics and climate modeling. Using the ECHAM/MESSy Atmospheric Chemistry (EMAC) climate model in combination with the Warning System for Aviation Exposure to SEP (WASAVIES), we investigate the transport, mixing, and deposition of the cosmogenic nuclide ¹⁰Be produced by the 774 CE/775 SPE. By comparing the model results to the reconstructed ¹⁰Be time series from four ice core records, we study the atmospheric pathways of ¹⁰Be from its stratospheric source to its sink at Earth's surface. The reconstructed post-SPE evolution of the ¹⁰Be surface fluxes at the ice core sites is well captured by the model. The downward transport of the ¹⁰Be atoms is controlled by the Brewer-Dobson circulation in the stratosphere and cross-tropopause transport via tropopause folds or large-scale sinking. Clear hemispheric differences in the transport and deposition processes are identified. In both polar regions the ¹⁰Be surface fluxes peak in summertime, with a larger influence of wet deposition on the seasonal ¹⁰Be surface flux in Greenland than in Antarctica. Differences in the peak ¹⁰Be surface flux following the 774 CE/775 SPE at the drilling sites are explained by specific meteorological conditions depending on the geographic locations of the sites
Interband mixing between two-dimensional states localized in a surface quantum well and heavy hole states of the valence band in narrow gap semiconductor
Theoretical calculations in the framework of Kane model have been carried out
in order to elucidate the role of interband mixing in forming the energy
spectrum of two-dimensional carriers, localized in a surface quantum well in
narrow gap semiconductor. Of interest was the mixing between the 2D states and
heavy hole states in the volume of semiconductor. It has been shown that the
interband mixing results in two effects: the broadening of 2D energy levels and
their shift, which are mostly pronounced for semiconductors with high doping
level. The interband mixing has been found to influence mostly the effective
mass of 2D carriers for large their concentration, whereas it slightly changes
the subband distribution in a wide concentration range.Comment: 12 pages (RevTEX) and 4 PostScript-figure
Zur Ablagerung der industriellen Abprodukte: 8. Mitteilung: Beitrag zur Ablagerung von Abprodukten aus dem Bereich der Farbenindustrie
Third post-Newtonian constrained canonical dynamics for binary point masses in harmonic coordinates
The conservative dynamics of two point masses given in harmonic coordinates
up to the third post-Newtonian (3pN) order is treated within the framework of
constrained canonical dynamics. A representation of the approximate Poincar\'e
algebra is constructed with the aid of Dirac brackets. Uniqueness of the
generators of the Poincar\'e group resp. the integrals of motion is achieved by
imposing their action on the point mass coordinates to be identical with that
of the usual infinitesimal Poincar\'e transformations. The second
post-Coulombian approximation to the dynamics of two point charges as predicted
by Feynman-Wheeler electrodynamics in Lorentz gauge is treated similarly.Comment: 42 pages, submitted to Phys. Rev.
Diffraction of complex molecules by structures made of light
We demonstrate that structures made of light can be used to coherently
control the motion of complex molecules. In particular, we show diffraction of
the fullerenes C60 and C70 at a thin grating based on a standing light wave. We
prove experimentally that the principles of this effect, well known from atom
optics, can be successfully extended to massive and large molecules which are
internally in a thermodynamic mixed state and which do not exhibit narrow
optical resonances. Our results will be important for the observation of
quantum interference with even larger and more complex objects.Comment: 4 pages, 3 figure
Inhibitory and agonistic autoantibodies directed against the ß(2)-adrenergic receptor in pseudoexfoliation syndrome and glaucoma
Pseudoexfoliation syndrome (PEXS) and glaucoma (PEXG) are assumed to be caused by a generalized elastosis leading to the accumulation of PEX material in ocular as well as in extraocular tissues. The exact pathophysiology of PEXS is still elusive. PEXG, the most common type of secondary open-angle glaucoma (OAG), is characterized by large peaks of intraocular pressure (IOP) with a progressive loss of the visual field. Agonistic autoantibodies (agAAbs) against the ß(2)-adrenergic receptor (AR) have been shown to be present in sera of patients with primary and secondary OAG and ocular hypertension and are seemingly linked to IOP. In the present study, we investigated the autoantibodies directed against the ß(2)-AR in sera of patients with PEXS and PEXG. We recruited 15, 10, and 15 patients with PEXG, PEXS, and primary OAG, respectively. Ten healthy individuals served as controls. All patients underwent standard ophthalmological examination with Octopus G1 perimetry. agAAbs prepared from serum samples were analyzed in a rat cardiomyocyte–based bioassay for the presence of agAAbs. We identified the interacting loop of the ß(2)-AR and the immunoglobulin G (IgG) subclasses using synthetic peptides corresponding to the extracellular loops of the receptors and enzyme-linked immunosorbent assay, respectively. None of the controls were ß(2)-agAAb–positive (0.2 ± 0.5 U). No ß(2)-agAAbs (0.2 ± 0.4 U), but inhibitory ß(2)-AAbs were observed in 80% of the patients that partially blocked the drug-induced ß(2)-adrenergic stimulation; 5.8 ± 1.7 U vs. 11.1 ± 0.9 U for clenbuterol in the absence and the presence of sera from patients with PEXS, respectively. Epitope analyses identified the third extracellular loop of the ß(2)-AR as the target of the inhibitory ß(2)-AAbs, being of IgG3 subtype in PEXS patients. In contrast, patients with PEXG showed ß(2)-agAAbs (5.6 ± 0.9 U), but no inhibitory ones. The ß(2)-agAAbs levels of patients with PEXG and primary OAG patients (3.9 ± 2.8 U; p > 0.05) were at a similar level. In two cases of PEXG, the ß(2)-agAAbs exert synergistic effects with clenbuterol. The activity increased from 11.5 ± 0.3 (clenbuterol only) to 16.3 ± 0.9 U. As autoimmune mechanisms were reportedly involved in the pathogenesis of glaucoma, agonistic and inhibitory ß(2)-AAbs seem to be a part of this multifactorial interplay
Resonances in a two-dimensional electron waveguide with a single delta-function scatterer
We study the conductance properties of a straight two-dimensional electron
waveguide with an s-like scatterer modeled by a single delta-function potential
with a finite number of modes. Even such a simple system exhibits interesting
resonance phenomena. These resonances are explained in terms of quasi-bound
states both by using a direct solution of the Schroedinger equation and by
studying the Green's function of the system. Using the Green's function we
calculate the survival probability as well as the power absorption and show the
influence of the quasi-bound states on these two quantities.Comment: 5 pages, 6 figures, to be published in Physical Review
Adjoint bi-continuous semigroups and semigroups on the space of measures
For a given bi-continuous semigroup T on a Banach space X we define its
adjoint on an appropriate closed subspace X^o of the norm dual X'. Under some
abstract conditions this adjoint semigroup is again bi-continuous with respect
to the weak topology (X^o,X). An application is the following: For K a Polish
space we consider operator semigroups on the space C(K) of bounded, continuous
functions (endowed with the compact-open topology) and on the space M(K) of
bounded Baire measures (endowed with the weak*-topology). We show that
bi-continuous semigroups on M(K) are precisely those that are adjoints of a
bi-continuous semigroups on C(K). We also prove that the class of bi-continuous
semigroups on C(K) with respect to the compact-open topology coincides with the
class of equicontinuous semigroups with respect to the strict topology. In
general, if K is not Polish space this is not the case
Anomalous spin-splitting of two-dimensional electrons in an AlAs Quantum Well
We measure the effective Lande g-factor of high-mobility two-dimensional
electrons in a modulation-doped AlAs quantum well by tilting the sample in a
magnetic field and monitoring the evolution of the magnetoresistance
oscillations. The data reveal that |g| = 9.0, which is much enhanced with
respect to the reported bulk value of 1.9. Surprisingly, in a large range of
magnetic field and Landau level fillings, the value of the enhanced g-factor
appears to be constant.Comment: 4 pages, 3 figure
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