210 research outputs found
The Bismut-Elworthy-Li type formulae for stochastic differential equations with jumps
Consider jump-type stochastic differential equations with the drift,
diffusion and jump terms. Logarithmic derivatives of densities for the solution
process are studied, and the Bismut-Elworthy-Li type formulae can be obtained
under the uniformly elliptic condition on the coefficients of the diffusion and
jump terms. Our approach is based upon the Kolmogorov backward equation by
making full use of the Markovian property of the process.Comment: 29 pages, to appear in Journal of Theoretical Probabilit
The chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC rather than via its neutralizing activity
Podoplanin (PDPN/Aggrus/T1α) binds to C-type lectin-like receptor-2 (CLEC-2) and induces platelet aggregation. PDPN is associated with malignant progression, tumor metastasis, and poor prognosis in several types of cancer. Although many anti-human PDPN (hPDPN) monoclonal antibodies (mAbs), such as D2-40 and NZ-1, have been established, these epitopes are limited to the platelet aggregation-stimulating (PLAG) domain (amino acids 29-54) of hPDPN. Recently, we developed a novel mouse anti-hPDPN mAb, LpMab-7, which is more sensitive than D2-40 and NZ-1, using the Cancer-specific mAb (CasMab) method. The epitope of LpMab-7 was shown to be entirely different from that of NZ-1, a neutralizing mAb against the PLAG domain according to an inhibition assay and lectin microarray analysis. In the present study, we produced a mouse-human chimeric anti-hPDPN mAb, chLpMab-7. ChLpMab-7 showed high antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Furthermore, chLpMab-7 inhibited the growth of hPDPN-expressing tumors in vivo. Although chLpMab-7 recognizes a non-PLAG domain of hPDPN, it suppressed the hematogenous metastasis of hPDPN-expressing tumors. These results indicated that chLpMab-7 suppressed tumor development and hematogenous metastasis in a neutralization-independent manner. In conclusion, hPDPN shows promise as a target in the development of a novel antibody-based therapy
On the predictable representation property of martingales associated with Lévy processes
Chimeric Anti-PDPN Antibody ChLpMab-2
Human podoplanin (hPDPN ), a platelet aggregation‐inducing transmembrane glycoprotein, is expressed in different types of tumors, and it binds to C‐type lectin‐like receptor 2 (CLEC ‐2). The overexpression of hPDPN is involved in invasion and metastasis. Anti‐hPDPN monoclonal antibodies (mAbs) such as NZ ‐1 have shown antitumor and antimetastatic activities by binding to the platelet aggregation‐stimulating (PLAG ) domain of hPDPN . Recently, we developed a novel mouse anti‐hPDPN mAb, LpMab‐2, using the cancer‐specific mAb (CasMab) technology. In this study we developed chLpMab‐2, a human–mouse chimeric anti‐hPDPN antibody, derived from LpMab‐2. chLpMab‐2 was produced using fucosyltransferase 8‐knockout (KO ) Chinese hamster ovary (CHO )‐S cell lines. By flow cytometry, chLpMab‐2 reacted with hPDPN ‐expressing cancer cell lines including glioblastomas, mesotheliomas, and lung cancers. However, it showed low reaction with normal cell lines such as lymphatic endothelial and renal epithelial cells. Moreover, chLpMab‐2 exhibited high antibody‐dependent cellular cytotoxicity (ADCC ) against PDPN ‐expressing cells, despite its low complement‐dependent cytotoxicity. Furthermore, treatment with chLpMab‐2 abolished tumor growth in xenograft models of CHO /hPDPN , indicating that chLpMab‐2 suppressed tumor development via ADCC . In conclusion, chLpMab‐2 could be useful as a novel antibody‐based therapy against hPDPN ‐expressing tumors
Statistical Analysis of a Semilinear Hyperbolic System Advected by a White in Time Random Velocity Field
We study a system of semilinear hyperbolic equations passively advected by
smooth white noise in time random velocity fields. Such a system arises in
modeling non-premixed isothermal turbulent flames under single-step kinetics of
fuel and oxidizer. We derive closed equations for one-point and multi-point
probability distribution functions (PDFs) and closed form analytical formulas
for the one point PDF function, as well as the two-point PDF function under
homogeneity and isotropy. Exact solution formulas allows us to analyze the
ensemble averaged fuel/oxidizer concentrations and the motion of their level
curves. We recover the empirical formulas of combustion in the thin reaction
zone limit and show that these approximate formulas can either underestimate or
overestimate average concentrations when reaction zone is not tending to zero.
We show that the averaged reaction rate slows down locally in space due to
random advection induced diffusion; and that the level curves of ensemble
averaged concentration undergo diffusion about mean locations.Comment: 18 page
A Delayed Black and Scholes Formula I
In this article we develop an explicit formula for pricing European options
when the underlying stock price follows a non-linear stochastic differential
delay equation (sdde). We believe that the proposed model is sufficiently
flexible to fit real market data, and is yet simple enough to allow for a
closed-form representation of the option price. Furthermore, the model
maintains the no-arbitrage property and the completeness of the market. The
derivation of the option-pricing formula is based on an equivalent martingale
measure
Associação entre características de desempenho de tilápia-do-nilo ao longo do período de cultivo.
O objetivo deste trabalho foi estimar as herdabilidades e a estrutura de correlações genéticas entre as características de desempenho de tilápia-do-nilo (Oreochromis niloticus) da linhagem GIFT, em diferentes estágios do ciclo de produção. As tilápias foram cultivadas em tanques - rede. Mediu-se ganho em peso diário total, peso vivo e ganho em peso diário, em quatro períodos, com intervalos de aproximadamente 30 dias. Foram realizadas análises unicaracter para as medidas, em todas as biometrias e, nas análises bicaracter, as medidas de mesma característica foram combinadas duas a duas e com o ganho em peso diário total. As estimações de herdabilidade variaram de 0,15 a 0,11 para peso vivo, 0,16 a 0,09 para ganho em peso diário e 0,17 a 0,12 para ganho em peso diário total, nas análises unicaracter. Os valores estimados de correlação genética para peso vivo e ganho em peso diário, associados ao ganho em peso diário total, variaram entre 0,37 a 0,98 e 0,74 a 0,8 respectivamente. A forte associação genética estimada entre peso vivo em biometrias intermediárias e ganho em peso diário total sugere que a seleção para velocidade de crescimento pode ser realizada de forma precoce
Analytic Controllability of Time-Dependent Quantum Control Systems
The question of controllability is investigated for a quantum control system
in which the Hamiltonian operator components carry explicit time dependence
which is not under the control of an external agent. We consider the general
situation in which the state moves in an infinite-dimensional Hilbert space, a
drift term is present, and the operators driving the state evolution may be
unbounded. However, considerations are restricted by the assumption that there
exists an analytic domain, dense in the state space, on which solutions of the
controlled Schrodinger equation may be expressed globally in exponential form.
The issue of controllability then naturally focuses on the ability to steer the
quantum state on a finite-dimensional submanifold of the unit sphere in Hilbert
space -- and thus on analytic controllability. A relatively straightforward
strategy allows the extension of Lie-algebraic conditions for strong analytic
controllability derived earlier for the simpler, time-independent system in
which the drift Hamiltonian and the interaction Hamiltonia have no intrinsic
time dependence. Enlarging the state space by one dimension corresponding to
the time variable, we construct an augmented control system that can be treated
as time-independent. Methods developed by Kunita can then be implemented to
establish controllability conditions for the one-dimension-reduced system
defined by the original time-dependent Schrodinger control problem. The
applicability of the resulting theorem is illustrated with selected examples.Comment: 13 page
Elliptic flow in Pb+Pb collisions at sqrt{s_{NN}} = 2.76 TeV: hybrid model assessment of the first data
We analyze the elliptic flow parameter v_2 in Pb+Pb collisions at
sqrt{s_{NN}} = 2.76 TeV and in Au+Au collisions at sqrt{s_{NN}} =200 GeV using
a hybrid model in which the evolution of the quark gluon plasma is described by
ideal hydrodynamics with a state-of-the-art lattice QCD equation of state, and
the subsequent hadronic stage by a hadron cascade model. For initial
conditions, we employ Monte-Carlo versions of the Glauber and the
Kharzeev-Levin-Nardi models and compare results with each other. We demonstrate
that the differential elliptic flow v_2(p_T) hardly changes when the collision
energy increases, whereas the integrated v_2 increases due to the enhancement
of mean transverse momentum. The amount of increase of both v_2 and mean p_T
depends significantly on the model of initialization.Comment: 5 pages, 5 figure
Fluctuation Relations for Diffusion Processes
The paper presents a unified approach to different fluctuation relations for
classical nonequilibrium dynamics described by diffusion processes. Such
relations compare the statistics of fluctuations of the entropy production or
work in the original process to the similar statistics in the time-reversed
process. The origin of a variety of fluctuation relations is traced to the use
of different time reversals. It is also shown how the application of the
presented approach to the tangent process describing the joint evolution of
infinitesimally close trajectories of the original process leads to a
multiplicative extension of the fluctuation relations.Comment: 38 page
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