Feedback first: the surprisingly weak effects of magnetic fields, viscosity, conduction, and metal diffusion on galaxy formation

Using high-resolution simulations with explicit treatment of stellar feedback physics based on the FIRE (Feedback in Realistic Environments) project, we study how galaxy formation and the interstellar medium (ISM) are affected by magnetic fields, anisotropic Spitzer-Braginskii conduction and viscosity, and sub-grid metal diffusion from unresolved turbulence. We consider controlled simulations of isolated (non-cosmological) galaxies but also a limited set of cosmological "zoom-in" simulations. Although simulations have shown significant effects from these physics with weak or absent stellar feedback, the effects are much weaker than those of stellar feedback when the latter is modeled explicitly. The additional physics have no systematic effect on galactic star formation rates (SFRs) . In contrast, removing stellar feedback leads to SFRs being over-predicted by factors of $\sim 10 -100$. Without feedback, neither galactic winds nor volume filling hot-phase gas exist, and discs tend to runaway collapse to ultra-thin scale-heights with unphysically dense clumps congregating at the galactic center. With stellar feedback, a multi-phase, turbulent medium with galactic fountains and winds is established. At currently achievable resolutions and for the investigated halo mass range $10^{10}-10^{13} M_{\odot}$, the additional physics investigated here (MHD, conduction, viscosity, metal diffusion) have only weak ($\sim10\%$-level) effects on regulating SFR and altering the balance of phases, outflows, or the energy in ISM turbulence, consistent with simple equipartition arguments. We conclude that galactic star formation and the ISM are primarily governed by a combination of turbulence, gravitational instabilities, and feedback. We add the caveat that AGN feedback is not included in the present work

The failure of stellar feedback, magnetic fields, conduction, and morphological quenching in maintaining red galaxies

The quenching "maintenance'" and related "cooling flow" problems are important in galaxies from Milky Way mass through clusters. We investigate this in halos with masses $\sim 10^{12}-10^{14}\,{\rm M}_{\odot}$, using non-cosmological high-resolution hydrodynamic simulations with the FIRE-2 (Feedback In Realistic Environments) stellar feedback model. We specifically focus on physics present without AGN, and show that various proposed "non-AGN" solution mechanisms in the literature, including Type Ia supernovae, shocked AGB winds, other forms of stellar feedback (e.g. cosmic rays), magnetic fields, Spitzer-Braginskii conduction, or "morphological quenching" do not halt or substantially reduce cooling flows nor maintain "quenched" galaxies in this mass range. We show that stellar feedback (including cosmic rays from SNe) alters the balance of cold/warm gas and the rate at which the cooled gas within the galaxy turns into stars, but not the net baryonic inflow. If anything, outflowing metals and dense gas promote additional cooling. Conduction is important only in the most massive halos, as expected, but even at $\sim 10^{14}\,{\rm M}_{\odot}$ reduces inflow only by a factor $\sim 2$ (owing to saturation effects and anisotropic suppression). Changing the morphology of the galaxies only slightly alters their Toomre-$Q$ parameter, and has no effect on cooling (as expected), so has essentially no effect on cooling flows or maintaining quenching. This all supports the idea that additional physics, e.g., AGN feedback, must be important in massive galaxies.Comment: 16 pages, 12 figure

Open Home Networks: the TEAHA Approach

The current trend for home appliances is networking. Although more and more of these appliances are networked, there is not a standard way of interaction, which restrains the development of services for in-home networks. The lack of standardisation is partly due to a legacy of business interests; white goods, audio video equipment, security, and personal digital appliances all have a different background and have different business models. Rather than profound standardisation we propose secure seamless interworking of technologies, applications, and business interests. In this paper we present an architecture which is embedded in legacy technology. Our approach combines known design patterns, augments existing technology, and facilitates so-called business clusters. Further, we discuss a prototype implementation that integrates as an example OSGI, ZIGBEE, and UPNP technology with CECED (white goods) business interests. The work reported in this paper has been executed in an international industrial project: TEAHA

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent

Objective: To determine if human colonic neuromuscular functions decline with increasing age.Design: Looking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (cholinergic/nitrergic) contractions/relaxations in ex vivomuscle strips of human ascending and descending colon, aged 35–91 years (macroscopically normal tissue; 239 patients undergoing cancer resection). Then, to understand mechanisms of change, numbers and phenotype of myenteric neurons (30 306 neurons stained with different markers), densities of intramuscular nerve fibres (51 patients in total) and pathways involved in functional changes were systematically investigated (by immunohistochemistry and use of pharmacological tools) in elderly (≥70 years) and adult (35–60 years) groups.Results: With increasing age, EFS was more likely to evoke muscle relaxation in ascending colon instead of contraction (linear regression: n=109, slope 0.49%±0.21%/year, 95% CI ), generally uninfluenced by comorbidity or use of medications. Similar changes were absent in descending colon. In the elderly, overall numbers of myenteric and neuronal nitric oxide synthaseimmunoreactive neurons and intramuscular nerve densities were unchanged in ascending and descending colon, compared with adults. In elderly ascending, not descending, colon numbers of cell bodies exhibiting choline acetyltransferase immunoreactivity increased compared with adults (5.0±0.6 vs 2.4±0.3 neurons/mm myenteric plexus, p=0.04). Cholinergically mediated contractions were smaller in elderly ascending colon compared with adults (2.1±0.4 and 4.1±1.1 g-tension/gtissue during EFS; n=25/14; p=0.04); there were no changes in nitrergic function or in ability of the muscle to contract/relax. Similar changes were absent in descending colon.Conclusion: In ascending not descending colon, ageing impairs cholinergic function

Cosmic Rays or Turbulence can Suppress Cooling Flows (Where Thermal Heating or Momentum Injection Fail)

The quenching ‘maintenance’ and ‘cooling flow’ problems are important from the Milky Way through massive cluster elliptical galaxies. Previous work has shown that some source of energy beyond that from stars and pure magnetohydrodynamic processes is required, perhaps from active galactic nuclei, but even the qualitative form of this energetic input remains uncertain. Different scenarios include thermal ‘heating’, direct wind or momentum injection, cosmic ray heating or pressure support, or turbulent ‘stirring’ of the intracluster medium (ICM). We investigate these in 10¹²−10¹⁴M⊙ haloes using high-resolution non-cosmological simulations with the FIRE-2 (Feedback In Realistic Environments) stellar feedback model, including simplified toy energy injection models, where we arbitrarily vary the strength, injection scale, and physical form of the energy. We explore which scenarios can quench without violating observational constraints on energetics or ICM gas. We show that turbulent stirring in the central ∼100 kpc, or cosmic ray injection, can both maintain a stable low-star formation rate halo for >Gyr time-scales with modest energy input, by providing a non-thermal pressure that stably lowers the core density and cooling rates. In both cases, associated thermal-heating processes are negligible. Turbulent stirring preserves cool-core features while mixing condensed core gas into the hotter halo and is by far the most energy efficient model. Pure thermal heating or nuclear isotropic momentum injection require vastly larger energy, are less efficient in lower mass haloes, easily overheat cores, and require fine tuning to avoid driving unphysical temperature gradients or gas expulsion from the halo centre

Functional and anatomical deficits in visceral nociception with age: a mechanism of silent appendicitis in the elderly?

The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral nociception in aged mouse and human tissue. Inflamed and noninflamed appendixes were collected from consenting patients undergoing surgery for the treatment of appendicitis or bowel cancer. Supernatants were generated by incubating samples in buffer and used to stimulate multiunit activity in intestinal preparations, or single-unit activity from teased fibres in colonic preparations, of young and old mice. Changes in afferent innervation with age were determined by measuring the density of calcitonin gene-related peptide-positive afferent fibres and by counting dorsal root ganglia back-labelled by injection of tracer dye into the wall of the colon. Finally, the effect of age on nociceptor function was studied in mouse and human colon. Afferent responses to appendicitis supernatants were greatly impaired in old mice. Further investigation revealed this was due to a marked reduction in the afferent innervation of the bowel and a substantial impairment in the ability of the remaining afferent fibres to transduce noxious stimuli. Translational studies in human tissue demonstrated a significant reduction in the multiunit but not the single-unit colonic mesenteric nerve response to capsaicin with age, indicative of a loss of nociceptor innervation. Our data demonstrate that anatomical and functional deficits in nociception occur with age, underpinning the atypical or silent presentation of appendicitis in the elderly

Ex vivo study of human visceral nociceptors.

OBJECTIVE: The development of effective visceral analgesics free of deleterious gut-specific side effects is a priority. We aimed to develop a reproducible methodology to study visceral nociception in human tissue that could aid future target identification and drug evaluation. DESIGN: Electrophysiological (single unit) responses of visceral afferents to mechanical (von Frey hair (VFH) and stretch) and chemical (bradykinin and ATP) stimuli were examined. Thus, serosal afferents (putative nociceptors) were used to investigate the effect of tegaserod, and transient receptor potential channel, vanilloid 4 (TRPV4) modulation on mechanical responses. RESULTS: Two distinct afferent fibre populations, serosal (n=23) and muscular (n=21), were distinguished based on their differences in sensitivity to VFH probing and tissue stretch. Serosal units displayed sensitivity to key algesic mediators, bradykinin (6/14 units tested) and ATP (4/10), consistent with a role as polymodal nociceptors, while muscular afferents are largely insensitive to bradykinin (0/11) and ATP (1/10). Serosal nociceptor mechanosensitivity was attenuated by tegaserod (-20.8±6.9%, n=6, p<0.05), a treatment for IBS, or application of HC067047 (-34.9±10.0%, n=7, p<0.05), a TRPV4 antagonist, highlighting the utility of the preparation to examine the mechanistic action of existing drugs or novel analgesics. Repeated application of bradykinin or ATP produced consistent afferent responses following desensitisation to the first application, demonstrating their utility as test stimuli to evaluate analgesic activity. CONCLUSIONS: Functionally distinct subpopulations of human visceral afferents can be demonstrated and could provide a platform technology to further study nociception in human tissue