75 research outputs found
Peranan Modal Dari Keluarga Pada 3 UKM di Bandung
Usaha kecil dan menengah menjadi bagian terbesar dari dunia usaha di Indonesia , yang telah terbukti mampu bertahan selama masa krisis, tahun 1997-1998 dan tahun 2008. Usaha skala kecil dan menengah ini (UKM) memiliki peran penting terhadap perkembangan ekonomi, menyerap jumlah tenaga kerja yang banyak memberikan kontribusi terhadap GDP. Ada suatu fakta yang belum cukup dipahami , bahwa berdirinya usaha skala kecil dan menengah umumnya dimulai dengan melibatkan anggota keluarga atau tidak langsung mendapat dukungan dan bantuan keluarga . Penelitian ini difokuskan untuk menemukan peran modal yang diberikan oleh keluarga pada saat pendirian usaha dan dalam perkembangannya, baik modal yang berupa uang dan finansial (harta tetap atau harta lancar), maupun yang bersifat nilai-nilai (family capital), dan emosi-waktu-perhatian (psychological capital) , dsb . Penelitian dilaksanakan dengan metode kualitatif yakni Multi Case Studies. Tiga UKM di Bandung dipilih sebagai obyek penelitian. Teknik wawancara dan observasi digunakan saling melengkapi . Hasil transkrip wawancara dikategorisasi (coding) sesuai tema penelitian. Teori modal Bourdieu (1996) digunakan untuk menganalisis dan untuk mendapatkan pemaknaan dari temuan. Temuan menunjukkan bahwa modal ekonomi bukanlah satu-satunya faktor yang berperan dalam memulai dan mengembangkan usaha dalam 3 kasus ini. Ada modal yang lain yaitu modal budaya dan modal sosial yang punya peran penting terhadap awal dan kelangsungan usaha. Modal simbolik dapat dibangun dari modal budaya sejalan dengan berjalannya usaha dalam jangka waktu yang cukup lama. Kata-kata Kunci : modal ekonomi, modal budaya, modal sosial, modal simboli
Perfil fermentativo, estabilidade aeróbia e valor nutritivo de silagens de capim-marandu ensilado com aditivos
Composição bromatológica e digestibilidade in vitro da matéria seca de silagens de milho e sorgo tratadas com inoculantes microbianos
The Public Repository of Xenografts enables discovery and randomized phase II-like trials in mice
More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease
Aditivos químicos e biológicos na ensilagem de cana-de-açúcar: 1. composição química das silagens, ingestão, digestibilidade e comportamento ingestivo
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 related protein (ATR) inhibition. Expression of PAX3-FOXO1 in muscle progenitor cells is not only sufficient to increase sensitivity to ATR inhibition, but PAX3-FOXO1-expressing rhabdomyosarcoma cells also exhibit increased sensitivity to structurally diverse inhibitors of ATR. Mechanistically, ATR inhibition leads to replication stress exacerbation, decreased BRCA1 phosphorylation and reduced homologous recombination-mediated DNA repair pathway activity. Consequently, ATR inhibitor treatment increases sensitivity of ARMS cells to PARP1 inhibition in vitro, and combined treatment with ATR and PARP1 inhibitors induces complete regression of primary patient-derived ARMS xenografts in vivo. Lastly, a genome-wide CRISPR activation screen (CRISPRa) in combination with transcriptional analyses of ATR inhibitor resistant ARMS cells identifies the RAS-MAPK pathway and its targets, the FOS gene family, as inducers of resistance to ATR inhibition. Our findings provide a rationale for upcoming biomarker-driven clinical trials of ATR inhibitors in patients suffering from ARMS
Efeito de enzimas fibrolíticas e do teor de matéria seca em silagens de capim-tanzânia sobre os parâmetros ruminais, o comportamento ingestivo e a digestão de nutrientes, em bovinos
Produtividade e valor nutricional da silagem de híbridos de milho em diferentes alturas de colheita
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