Model Test on Impact of Surrounding Rock Deterioration on Segmental Lining Structure for Underwater Shield Tunnel with Large Cross-Section

AbstractBased on Guangzhou Shiziyang Tunnel, a large-scale model test of segment lining structure was conducted to study the impact of surrounding rock deterioration. The results showed the outflow or deterioration of surrounding rock at the hence could make the stress state at the bottom and crown more serious. And it is very important to provide effective surrounding rock resistance to ensure the safety of tunnel structure

Effect of fish meal replacement by Chlorella meal with dietary cellulase addition on growth performance, digestive enzymatic activities, histology and myogenic genes' expression for crucian carp Carassius auratus

This study was conducted to investigate the effects of fish meal (FM) replacement by Chlorella meal (CM) with dietary cellulase supplementation on growth performance, digestive enzymatic activities, histology and myogenic genes&#39; expression in crucian carp Carassius auratus (initial body weight: 2.90 +/- 0.02 g, mean +/- SEM). Six isonitrogenous diets were formulated at two cellulase levels (0 and 2 g kg(-1)). At each cellulase level, CM was added at three levels of 0, 533.1 and 710.8 g kg(-1) to substitute 0, 75 and 100% of dietary FM respectively. Each experimental diet was randomly assigned to triplicate groups with 25 juvenile fish per fibreglass tank for 8 weeks. Dietary CM substitution significantly increased growth, feed utilization, amylase activity and the expression of Myod, Mrf4 and Myf5, but reduced the Myog expression. Dietary cellulase addition increased hepatosomatic and viscerosomatic index, lipase activity and the expression of Mrf4, but reduced trypsin activity and the expression of Myog and Myf5. Dietary CM substitution enlarged the cell size and also caused some karyopyknosis in liver. Our results showed that CM could totally replace FM in diets; dietary cellulase supplementation at the level of 2 g kg(-1) played a subtle role in improving growth and feed utilization for crucian carp.</p

Unsupervised Domain Adaptation via Discriminative Manifold Embedding and Alignment

Unsupervised domain adaptation is effective in leveraging the rich information from the source domain to the unsupervised target domain. Though deep learning and adversarial strategy make an important breakthrough in the adaptability of features, there are two issues to be further explored. First, the hard-assigned pseudo labels on the target domain are risky to the intrinsic data structure. Second, the batch-wise training manner in deep learning limits the description of the global structure. In this paper, a Riemannian manifold learning framework is proposed to achieve transferability and discriminability consistently. As to the first problem, this method establishes a probabilistic discriminant criterion on the target domain via soft labels. Further, this criterion is extended to a global approximation scheme for the second issue; such approximation is also memory-saving. The manifold metric alignment is exploited to be compatible with the embedding space. A theoretical error bound is derived to facilitate the alignment. Extensive experiments have been conducted to investigate the proposal and results of the comparison study manifest the superiority of consistent manifold learning framework.Comment: Accepted to AAAI 2020. Code available: \<https://github.com/LavieLuo/DRMEA

Coherent Time-Varying Graph Drawing with Multifocus+Context Interaction

Abstract—We present a new approach for time-varying graph drawing that achieves both spatiotemporal coherence and multifocus+context visualization in a single framework. Our approach utilizes existing graph layout algorithms to produce the initial graph layout, and formulates the problem of generating coherent time-varying graph visualization with the focus+context capability as a specially-tailored deformation optimization problem. We adopt the concept of the super graph to maintain spatiotemporal coherence and further balance the needs for aesthetic quality and dynamic stability when interacting with time-varying graphs through focus+context visualization. Our method is particularly useful for multifocus+context visualization of time-varying graphs where we can preserve the mental map by preventing nodes in the focus from undergoing abrupt changes in size and location in the time sequence. Experiments demonstrate that our method strikes a good balance between maintaining spatiotemporal coherence and accentuating visual foci, thus providing a more engaging viewing experience for the users. Index Terms—Graph drawing, time-varying graphs, spatiotemporal coherence, focus+context visualization

Relaxed Viscosity Approximation Methods with Regularization for Constrained Minimization Problems

We introduce a new relaxed viscosity approximation method with regularization and prove the strong convergence of the method to a common fixed point of finitely many nonexpansive mappings and a strict pseudocontraction that also solves a convex minimization problem and a suitable equilibrium problem

Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways

<p>Abstract</p> <p>Background</p> <p>Human herpesvirus 6 (HHV-6) is a T-lymphtropic and neurotropic virus that can infect various types of cells. Sequential studies reported that apoptosis of glia and neurons induced by HHV-6 might act a potential trigger for some central nervous system (CNS) diseases. HHV-6 is involved in the pathogenesis of encephalitis, multiple sclerosis (MS) and fatigue syndrome. However, the mechanisms responsible for the apoptosis of infected CNS cells induced by HHV-6 are poorly understood. In this study, we investigated the cell death processes of primary human fetal astrocytes (PHFAs) during productive HHV-6A infection and the underlying mechanisms.</p> <p>Results</p> <p>HHV-6A can cause productive infection in primary human fetal astrocytes. Annexin V-PI staining and electron microscopic analysis indicated that HHV-6A was an inducer of apoptosis. The cell death was associated with activation of caspase-3 and cleavage of poly (ADP-ribose) polymerase (PARP), which is known to be an important substrate for activated caspase-3. Caspase-8 and -9 were also significantly activated in HHV-6A-infected cells. Moreover, HHV-6A infection led to Bax up-regulation and Bcl-2 down-regulation. HHV-6A infection increased the release of Smac/Diablo, AIF and cytochrome c from mitochondria to cytosol, which induced apoptosis via the caspase-dependent and -independent pathways. In addition, we also found that anti-apoptotic factors such as IAPs and NF-κB decreased in HHV-6A infected PHFAs.</p> <p>Conclusion</p> <p>This is the first demonstration of caspase-dependent and -independent apoptosis in HHV-6A-infected glial cells. These findings would be helpful in understanding the mechanisms of CNS diseases caused by HHV-6.</p

catena-Poly[[tetra­aqua­zinc(II)]-μ-1,3,4-thia­diazol-2,5-diyldithio­diacetato-κ2 O:O′]

In the title linear coordination polymer, [Zn(C6H4N2O4S3)(H2O)4]n, the ZnII atom is coordinated by four O atoms from four water mol­ecules and two O atoms from two [5-(carb­oxyl­atomethyl­sulfan­yl)-1,3,4-thia­diazol-2-ylsulfan­yl]acetate units in an octa­hedral coordination environment. The chains are linked into a three-dimensional supra­molecular network via O—H⋯O and O—H⋯N hydrogen bonds

Filtering one-way Einstein-Podolsky-Rosen steering

Einstein-Podolsky-Rosen (EPR) steering, a fundamental concept of quantum nonlocality, describes one observer's capability to remotely affect another distant observer's state by local measurements. Unlike quantum entanglement and Bell nonlocality, both associated with the symmetric quantum correlation, EPR steering depicts the unique asymmetric property of quantum nonlocality. With the local filter operation in which some system components are discarded, quantum nonlocality can be distilled to enhance the nonlocal correlation, and even the hidden nonlocality can be activated. However, asymmetric quantum nonlocality in the filter operation still lacks a well-rounded investigation, especially considering the discarded parts where quantum nonlocal correlations may still exist with probabilities. Here, in both theory and experiment, we investigate the effect of the local filter on EPR steering. We observe all configurations of EPR steering simultaneously and other intriguing evolution of asymmetric quantum nonlocality, such as reversing the direction of one-way EPR steering. This work provides a complementary perspective to understand the asymmetric quantum nonlocality and demonstrates a practical toolbox for manipulating asymmetric quantum systems with significant potential applications in quantum information tasks.Comment: 11pages, 7figure

Optical realization of universal quantum cloning

Beyond the no-cloning theorem, the universal symmetric quantum cloning machine was first addressed by Buzek and Hillery. Here, we realized the one-to-two qubits Buzek-Hillery cloning machine with linear optical devices. This method relies on the representation of several qubits by a single photon. We showed that, the fidelities between the two output qubits and the original qubit are both 5/6 (which proved to be the optimal fidelity of one-to-two qubits universal cloner) for arbitrary input pure states.Comment: 5 Pages, 2 Figure