16 research outputs found
Pulse radiolytic studies on cis-dichlorobis-(2,2'-bipyridine)cobalt(III) and cis-dichlorobis-(1,10-phenanthroline)cobalt(III) complexes
690-694The reactions of hydrated electron (eā»q) with Co(III) polypyridyl complexes of the type [Co(NN)2Cl2]Cl where NN = 2,2'-bipyridine (bpy), and 1,10-phenanthroline (phen) have been studied by pulse radiolysis. The rate constants for the reactions at 300 K have been evaluated to be (7.6Ā±0.2)x10Ā¹ā°, and (6.9Ā±0.2)x10Ā¹ā° dmĀ³ molā»Ā¹ sā»Ā¹, respectively. Time resolved transient absorption spectra show two broad peaks at 360 and 610 nm for the bpy complex and a single broad peak at 420 nm for the phen complex at 1 Ī¼s. Comparison with reported transient spectra of the anion radicals of ligands indicates that the electron is located on the complex as a whole. The anion radicals of both the complexes initially produced, decay in the time scale of ~80 Ī¼s. Steady state absorption spectra on irradiation point out to breakdown of the phen complex, and the bpy-Co(III) complex is reduced to Co(II) complex. Conductance of the solution substantially increases on irradiation for both the complexes and can be attributed to aquation/de-ligation of the phen complex. The phen complex anion radical undergoes aquation/de-ligation by intramolecular electron transfer leading to dissociation of the complex. For bpy complex the conductance increases due to the release of chloride ions and reduction to Co(II) complex species is observed
Case Report Congenital Thrombotic Thrombocytopenic Purpura: An Unusual Case of Microangiopathic Haemolytic Anaemia in a Newborn
ABSTRACT We present an extremely rare case of hyperbilirubinemia with rapid progression leading to bilirubin encephalopathy in term neonate. Despite early recognition and intervention, death occurred as a total serum bilirubin reached 25 mg/dl. It was a case of Coomb's negative microangiopathic haemolytic anaemia in a newborn period which is autosomal recessive inheritance i.e. Upshaw-Schulman Syndrome. (Congenital thrombotic thrombocytopenic purpura) characterised by numerous schistocytes on peripheral blood smear, thrombocytopenia , increased reticulocyte count, increased bilirubin and LDH level. This rare disease is often misdiagnosed especially in newborn baby. So we present this case not only for its variety but also for to create more awareness among pathologist and paediatrician as treatment protocol entirely differ
INCULCATING RESEARCH CULTURE FOR OVERALL DEVELOPMENT OF THE STUDENTS, TEACHERS AND INSTITUTION
<p>The progress of a country is possible only when its citizens are dynamic, enterprising and</p>
<p>responsible. Higher educational institutes contribute to the growth of nation by providing specialized</p>
<p>knowledge and skilled man power. The universities and colleges performing role in higher education</p>
<p>have several functions. The students of 21st century era are really well awarded, well informed and their</p>
<p>energy needs to be channelized in the right direction to achieve quality and better personality</p>
<p>development. The research is therefore having become an important component of every academic</p>
<p>institution at higher education level. Research, consultancy and extension parameter is more effectively</p>
<p>in operation at our college. Due to the components of this parameter, the students are getting benefited.</p>
<p>They are acquiring skills of research and well as involving social activities for the benefit of mankind.</p>
<p>The promising facts of research, research culture and its impact are summarized in the text.</p>
<p></p
Light-driven Hydrogen Evolution from Water by a Tripodal Silane Based Co<sup>II</sup><sub>6</sub>L<sup>1</sup><sub>8</sub> Octahedral Cage
The
octahedral cage assembly [Co<sup>II</sup><sub>6</sub>L<sup>1</sup><sub>8</sub>Cl<sub>6</sub>(H<sub>2</sub>O)<sub>6</sub>]ĀCl<sub>6</sub> has been synthesized in a single-step reaction by using a polypyridyl-functionalized
tripodal silane ligand. The electrochemical behavior of the cage in
water exhibits the pH dependence of potential as well as catalytic
current indicating the possible involvement of proton-coupled electron
transfer in H<sub>2</sub> evolution. Electrocatalytic hydrogen evolution
from an aqueous buffered solution gave a turnover frequency of 16
h<sup>ā1</sup>. Further, this cage assembly has been explored
as a photocatalyst (blue light irradiation Ī» 469 nm) for the
evolution of H<sub>2</sub> from water in the presence of RuĀ(bpy)<sub>3</sub><sup>2+</sup> as a photosensitizer and ascorbic acid as a
sacrificial electron donor. This catalytic reaction is found to be
pseudo first order with a turnover frequency of 20.50 h<sup>ā1</sup>
Antiproliferative activity of ruthenium(ii) arene complexes with mono- and bidentate pyridine-based ligands
A series of Ru(II) arene complexes of mono- and bidentate N-donor ligands with carboxyl or ester groups and chlorido ancillary ligands were synthesised and structurally characterised. The complexes have a distorted tetrahedral piano-stool geometry. The binding interaction was studied with calf thymus DNA (CT-DNA) by absorption titration, viscosity measurement, thermal melting, circular dichroism, ethidium bromide displacement assay and DNA cleavage of plasmid DNA (pBR322), investigated by gel electrophoresis. The dichlorido complexes bind covalently to DNA in the dark, similar to cisplatin, while the monochlorido complexes bind covalently on irradiation, similar to cisplatin analogues. The compounds are selectively cytotoxic against several tumour cell lines and show specific nonlinear correlation between dose and activity. This phenomenon is closely related to their potential to act preferentially as inhibitors of cell division
Thermodynamics of Azo Dye Adsorption on a Newly Synthesized Titania-Doped Silica Aerogel by Cogelation: A Comparative Investigation with Silica Aerogels and Activated Charcoal
The adsorption isotherms of azo dyes on a newly synthesized
titania-doped
silica (TdS) aerogel compared to silica aerogels and activated charcoal
(AC) are systematically investigated. Monolithic TdS aerogels were
synthesized by the cogelation process followed by supercritical drying
of tetraethyl orthosilicate (TEOS) as a gel precursor and titanium(IV)
isopropoxide (TTIP) as a metal complex precursor for co-polymerization
in ethanol solvent. An acidābase catalyst was used for the
hydrolysis and condensation of TEOS and TTIP. The effect of Ti4+ doping in a silica aerogel on the mesoporous structure and
the adsorption capacity of methylene blue (MB) and crystal violet
(CV) dyes were evaluated from the UVāvis absorption spectra.
In order to compare the adsorption isotherms, the surface areas of
silica and TdS aerogels were first normalized with respect to AC,
as adsorption is a surface phenomenon. The azo dye equilibrium adsorption
data were analyzed using different isotherm equations and found to
follow the Langmuir adsorption isotherm. The maximum monolayer adsorption
capacities for the adsorbent TdS aerogel normalized with the AC of
the Langmuir isotherm are 131.58 and 159.89 mg/g for MB and CV dyes,
respectively. From the Langmuir curve fitting, the Qmax value of the TdS aerogel was found to increase by
1.22-fold compared to AC, while it increased 1.25ā1.53-fold
compared to the silica aerogel. After four cycles, regeneration efficiency
values for MB and CV dyes are about 84 and 80%, respectively. The
study demonstrates the excellent potential and recovery rate of silica
and TdS aerogel adsorbents in removing dyes from wastewater. The pore
volume and average pore size of the new aerogel, TdS, were found to
be lower than those of the silica aerogel. Thus, a new TdS aerogel
with a high capacity of adsorption of azo dyes is successfully achieved
Acetylcholinesterase and AĪ² Aggregation Inhibition by Heterometallic Ruthenium(II)āPlatinum(II) Polypyridyl Complexes
Two
heteronuclear rutheniumĀ(II)āplatinumĀ(II) complexes [RuĀ(bpy)<sub>2</sub>(BPIMBp)ĀPtCl<sub>2</sub>]<sup>2+</sup> (<b>3</b>) and
[RuĀ(phen)<sub>2</sub>(BPIMBp)ĀPtCl<sub>2</sub>]<sup>2+</sup> (<b>4</b>), where bpy = 2,2ā²-bipyridine, phen = 1,10-phenanthroline,
and BPIMBp = 1,4ā²-bisĀ[(2-pyridin-2-yl)-1H-imidazol-1-ylmethyl]-1,1ā²-biphenyl,
have been designed and synthesized from their mononuclear precursors
[RuĀ(bpy)<sub>2</sub>(BPIMBp)]<sup>2+</sup> (<b>1)</b> and [RuĀ(phen)<sub>2</sub>(BPIMBp)]<sup>2+</sup> (<b>2</b>) as multitarget molecules
for Alzheimerās disease (AD). The inclusion of the cis-PtCl<sub>2</sub> moiety facilitates the covalent interaction of RuĀ(II) polypyridyl
complexes with amyloid Ī² (AĪ²) peptide. These multifunctional
complexes act as inhibitors of acetylcholinesterase (AChE), AĪ²
aggregation, and Cu-induced oxidative stress and protect neuronal
cells against AĪ²-toxicity. The study highlights the design of
metal based anti-Alzheimerās disease (AD) systems