Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy

Developing a nanotheranostic agent with better image resolution and high accumulation into solid tumor microenvironment is a challenging task. Herein, we established a light mediated phototriggered strategy for enhanced tumor accumulation of nanohybrids. A multifunctional liposome based nanotheranostics loaded with gold nanoparticles (AuNPs) and emissive graphene quantum dots (GQDs) were engineered named as NFGL. Further, doxorubicin hydrochloride was encapsulated in NFGL to exhibit phototriggered chemotherapy and functionalized with folic acid targeting ligands. Encapsulated agents showed imaging bimodality for in vivo tumor diagnosis due to their high contrast and emissive nature. Targeted NFGL nanohybrids demonstrated near infrared light (NIR, 750 nm) mediated tumor reduction because of generated heat and Reactive Oxygen Species (ROS). Moreover, NFGL nanohybrids exhibited remarkable ROS scavenging ability as compared to GQDs loaded liposomes validated by antitumor study. Hence, this approach and engineered system could open new direction for targeted imaging and cancer therapy.publishersversionpublishe

Pollinators: Their Relevance in Conservation and Sustainable Agro-Ecosystem

Survival and reproduction of several wild plants and crops is mostly by insects pollinator, their recognition and importance have been increased in this climatic changing scenario, which affects the various aspects of their life cycle. According to an estimate, approximately 30,000 species of bees are known in entomology, and about 190 species of bees have been reported to be associated with pollination. There can be an established link between seed production and pollinator diversity, for the plants with a generalist pollination system. The increasing of human habitation affects insect pollinators in various ways, i.e. of habitat destruction, results in low availability of food sources, nesting, oviposition, resting, and mating sites. Pollinator availability restraints the geographical distribution of plant species, i.e. to develop an ecological niche of certain plant species. Failure of pollinator- plant interaction mutualism results in lower seed production and sometimes extirpation of plant population has been recorded. The declining pollinators’ population strengthens existing plant-pollinator interaction or allows new pant pollinator interaction to form. Maintaining the commercial and wild pollinator populations and preventing future shortages of pollination services, therefore, is extremely significant

भारतीय तटीय जल में तेल प्रदूषण की स्थिति

भारतीय तटीय जल में तेल प्रदूषण की स्थित

FOOD ALLERGY: AN OVERVIEW

oai:ojs.pkp.sfu.ca:article/1The immune system protects our body against pathogens and other foreign substances by producing a kind of glycoprotein known as immunoglobulin or antibodies from plasma cells or B-cells. Surveys show that about one-third of all adults believe they have food allergies. About 4-8% percent of young children are diagnosed with food allergies, most of which are evident in the first years of life and are often outgrown. A food allergy is any adverse reaction to an otherwise harmless food or food component that involves the body’s immune system. In others words, a food allergy is an immune system response to a food that the body mistakenly believes is harmful. Components of a food that trigger the immune system are called food allergens. Cows’ milk allergy appears to be among the more prevalent food allergies in infants. Eggs and peanuts are also common allergenic foods for infants, along with soybeans, tree nuts, fish, and wheat. Seafood allergies, especially to crustaceans (shrimp, crab, lobster) are also rather common among adults. The present review provides brief information about food allergy and allergic reactions, their types, symptoms and approaches for reduction

Synthesis, antimalarial activity evaluation and molecular docking studies of some novel dispiro-1,2,4,5-tetraoxanes

Seven novel dispiro-1,2,4,5-tetraoxane derivatives were synthesized and characterized by a number of analytical and spectroscopic techniques. The molecules were subsequently screened for in vitro antimalarial activity against chloroquine resistant strain of Plasmodium falciparum (RKL-9). At antimalarial activity screening, two compounds, namely 5d (MIC = 15.6 µg/mL or 64.5 µM) and 5f (MIC = 15.6 µg/mL or 54.6 µM) were found to be about 1.5 times more potent against chloroquine resistant strain-RKL-9 compared to chloroquine (MIC = 25.0 µg/mL or 78.3 µM). Molecular docking studies of potent ligands were also performed in cysteine protease binding pocket residues of falcipain-2 as a target protein

A Brief Survey on Channel Estimation Schemes in OFDM System

microwave access) framework has been as of late connected generally in remote correspondence frameworks [1]. WiMAX utilizes OFDM as a specialized stage due to high otherworldly productivity [2], [3]. In this paper, the channel estimation calculations are mulled over for versatile WiMAX framework. The brush pilot structure is utilized for channel estimation calculations. We built an ideal calculation of channel estimation dependent upon Kalman channel joining with GI (watch interim) streamlining calculation and after that contrasted and LS (slightest square) estimator, Kalman estimator-altered GI. The general study demonstrated that the Kalman estimator joining with gatekeeper interim streamlining calculation had the best execution in this paper

Atypically Large Arteriovenous Malformation: A Surgical Challenge

Arteriovenous malformation (AVM) is an abnormal connection between arteries and veins, bypassing the capillary system. The majority of AVMs involve the extremities, head and neck, and lungs. We report a case of a 20-year-old female with a large, high flow AVM at unusual location. The perforators of this malformation were originating directly from lumbar arteries, revealed by computed tomography angiography. In the absence of facilities of embolizing feeder vessels, such large AVM gave us a great surgical challenge in terms of dissection, raising the mass, ligating perforators, and avoiding skin loss

Voltage Profile Improvement, Transmission Line Loss Reduction in Rajasthan Power System: A Case Study

The complexity is increasing day by day with the advancement of buses in interconnected power system. The complexity of the power system can easily handle by analyzing the performance of the transmission system by using load flow study. The real and reactive power losses are largely affected at the transmission level. This paper presents case study of real time system operation to reduce losses and improve the voltage profile with optimum utilization of existing transmission system elements. West-North part of Rajasthan power system having one 400 kV GSS, five 220 kV GSS and nineteen 132 kV GSS have been selected to carry out case study and simulated in PSSE software. Simulation model consists of 55 buses, 34 transmission lines, 66 transformers and 34 capacitor banks. Eight cases have been simulated considering the effect of transformer tap position, closing of opened transmission lines and shunt capacitors. From simulation studies it is found out that transmission losses are reduced by 50.36 % in addition to improve network voltage profile