4 research outputs found
<span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:black;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">Antidiabetic and antioxidant effects of S -methyl cysteine sulfoxide isolated from onions (<i>Allium cepa</i> Linn) as compared to standard drugs in alloxan diabetic rats</span>
1005-1009<span style="font-size:14.0pt;line-height:
115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:black;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">Antidiabetic and antoxidant effects of S-methyl cysteine sulfoxide (SMCS)
isolated from A.cepa and two standard drugs, glibenclamide and insulin
were studied and compared in alloxan diabetic rats after using each of them for
treatment for two months. These drugs ameliorated the diabetic condition
significantly, viz. maintenance of body weight and control of blood sugar in
rats. Further they lowered the levels of malondialdehyde, hydroperoxide and
conjugated dienes in tissues exhibiting antioxidant effect on lipid peroxidation
in experimental diabetes. This is achieved by their stimulating effects on glucose
utilization and the antioxidant enzymes, viz. superoxide dismutase and
catalase. The probable mechanism of action of SMCS and glibenclamide may be
partly dependent on the stimulation of insulin secretions and partly due to their
individual actions. In the amelioration of diabetes the standard drugs showed a
better action, but as an antioxidant SMCS proved to be a better one.</span