News, Literacy and Public Policy: Changing Modes and Perceptions of Policy Literacy

This paper seeks to study the changing relationship between news and public policies. It would address the changing modes of reporting along with changes in different strands in public policy, its instruments and actors. Conventional literature in the field provides a broader perspective related to news and public policy. It is claimed that "relationship between news coverage and the evolution of public policy is extremely circular," especially in regard to "who influences whom" . The journalistic field may presume public policy as function of news, whereas, policymakers may assume otherwise, public policies make news. Finally, the paper argues that impact of media "matter, not just at the beginning but throughout the policy process." Hence, the study merits attention both at theoretical as well as substantive levels to problematize the relationship in Indian context

ERECTILE DYSFUNCTION AND ITS PHARMACOLOGY: AN OVERVIEW

It has been estimated that currently over 150 million men worldwide suffer from erectile dysfunction (ED) and by 2025, the figure will increase beyond 322 millions. ED is the inability to achieve, and/or maintain penile erection sufficient for satisfactory sexual intercourse, and was previously regarded as the part of aging. It is associated with certain diseases and life style habits with a cause-effect relationship, including diabetes mellitus, hypertension, dyslipidemia, and cigarette smoking. Internationally, most of the men with ED fail to pursue treatment due to the complex nature of sexuality, taboos, cultural restrictions, and acceptance of ED as a normal sequel of aging. In this review, we discussed the physiology, diagnosis, and risk factors associated with ED and current treatment strategies for ED.Keywords: Erectile dysfunction, Diabetes, Penile erection, Phosphodiesterase inhibitors

Design and synthesis of novel quercetin metal complexes as IL-6 inhibitors for anti-inflammatory effect in SARS-CoV-2

One of the most common causes of mortality in COVID-19 patients is cytokine release syndrome (CRS). Though several cytokines are involved in CRS, the role of Interleukin 6 is significant. Considering the importance of IL-6 inhibition and the drawbacks of the existing monoclonal antibodies, the present study develops new flavonoid metal complexes as immune boosters targeting IL-6 for SARS-CoV-2 treatment. To identify the potential flavonoids from 152 secondary plant metabolites, PyRx 0.9 tool has been used. The top scorer quercetin was converted into quercetin-oxime. Seven metal complexes (QM-1 to QM-7) were made from quercetin-oxime by utilizing divalent metals such as zinc, copper, magnesium, cobalt, barium, and cadmium. It was assumed that all compounds were moderately soluble and would not penetrate the BBB through in silico ADME studies. However, the in vitro heamolytic research revealed a modest heamolytic effect in all seven complexes. To know the IL-6 inhibitory potential preliminary level, the complexes were screened for cytotoxicity in cell lines MCF-7 which predominantly expresses the IL-6 level. The cytotoxic effects of all complexes were considerable relative to the marketable Nutridac formulation. The complexes quercetin-Zinc (QM1) and quercetin-Zinc-Ascorbic acid (QM7) showed significant cytotoxicity on MCF-7 compared to Nutridac and no cytotoxic toward the normal cell lines

A Comparative Study of Chain Clamping Fixture with Other Clamping Methods for Gate Valve Body: Cycle Time and Rigidity Study

“Fixture rigidity influences the production rates”. In this paper, a comparison and feasibility study is demonstrated to improve the productivity and existing fixture rigidity for machining on a gate valve body by comparing the existing technique i.e. top clamping fixture with other possible clamping methods including newly developed chain clamping fixture. The CAD models of the fixtures are prepared in CATIA V5. The existing fixture concept, clamping methods, cutting parameters and cycle times have been studied and compared with the values of chain clamping fixture obtained by trail out results. Along with the increased production rates, other parameters like tool life, noise and vibration levels and surface roughness values are also improved slightly

A Comparative Study of Chain Clamping Fixture with Other Clamping Methods for Gate Valve Body: Cycle Time and Rigidity Study

“Fixture rigidity influences the production rates”. In this paper, a comparison and feasibility study is demonstrated to improve the productivity and existing fixture rigidity for machining on a gate valve body by comparing the existing technique i.e. top clamping fixture with other possible clamping methods including newly developed chain clamping fixture. The CAD models of the fixtures are prepared in CATIA V5. The existing fixture concept, clamping methods, cutting parameters and cycle times have been studied and compared with the values of chain clamping fixture obtained by trail out results. Along with the increased production rates, other parameters like tool life, noise and vibration levels and surface roughness values are also improved slightly

Application of Integrated BWM Fuzzy-MARCOS Approach for Coating Material Selection in Tooling Industries

The life of metal forming dies and the efficiency of tooling industries depends on the mechanical and wear properties of tool steel. These properties can be further improved by depositing the ceramic coating on heat-treated tool steel. Numerous coating materials with various excellent features are already available commercially; however, the selection of the best coating material is still an immense challenge for users. Compared to various studies related to material selection problems in the contrasting area of utilization, remarkably, little research work has been done in tooling industries. In the present work, we have identified eight coating materials (alternatives) and nine evaluation criteria under the consultation of an expert in the tooling application and tribological field. To deal with this coating material selection problem, an integrated fuzzy-multi attributed decision-making method is proposed which comprises best worst method and fuzzy-Measurement Alternatives and Ranking according to the Compromise Solution method. This integrated fuzzy- multi attributed decision-making method is used to evaluate the alternatives, and the obtained results were scrutinized via utilizing various sensitivity analysis procedures. In the first phase of analysis, seven scenarios of criteria weight change were used, which was derived by the best-worst method; dynamic matrices are used in the second phase of analysis. In the third and fourth phases, obtained ranks were compared with those obtained by different weight calculation methods and ranking methods, respectively. In the present study, AlCrN/TiAlN coating (alternative Cm5) was found to be the best coating material based on the results obtained after sensitivity analysis. Further, in this study, we have proposed a novel method that helps to solve the coating material selection problem or any kind of selection complications

CCAM: A comprehensive cost analysis model for video-on-demand system

This paper presents the study on the cost analysis for the Video-on-Demand (VoD) system exploiting the advantages of the Peer-to-Peer (P2P) architecture. Our objective is to tackle the problems in analyzing cost and to come up with efficient cost analysis model (CCAM) thereby enhancing the revenue to the system. We adopt a partially decentralized P2P architecture with a cluster based approach to find the probability of the requests for the videos in that cluster and to place the videos closer to the customers. The results of the simulation experiment demonstrates that most of the video requests are delivered to the customers almost immediately with a faster response-time. The results also indicate that our approach accomplishes maximum revenue with less rejection ratio and a moderate peer-load when compared to the conventional approach which uses random arrival pattern contributing a substantial revenue to the VoD system. ©2010 IEEE

A hybrid approach for providing quality of service in video-on-demand system

Distributed multimedia applications deployed in a heterogeneous environment must ensure that the user experiences seamless delivery of data. The challenging task in multimedia applications is to satisfy numerous requests for different videos with limited resources by invoking various Quality of Service (QoS) mechanisms and policies. In this paper, a hybrid QoS strategy, which is a combination of batching and recursive patching is implemented in the local server to ensure starvation-free resource management thereby enhancing the throughput. Batching shares network resources efficiently whereas recursive patching is adopted to reduce the time difference between the requests. The proposed algorithm delivers the complete video to the users based on one of the three communication channels: broadcast, multicast and unicast depending on whether the video is most popular, average popular and least popular respectively. The simulation results show that our strategy achieves 35-40 reduction in terms of blocking ratio and throughput is 10-15 higher than the Poon's strategy 16, which guarantees that not only the resources are efficiently utilized but also a suitable Quality of Service is provided to each user

LI-Care: A LabVIEW and IoT Based eHealth Monitoring System

This paper presents a Laboratory Virtual Instrument Engineering Workbench (LabVIEW) and Internet of Things (IoT)-based eHealth monitoring system called LI-Care to facilitate the diagnosis of the health condition cost-effectively. The system measures the heart rate, body temperature, blood pressure, oxygen level, and breathing rate, and provides an electrocardiogram (ECG). The required sensors are integrated on a web-based application that keeps track of the essential parameters and gives an alarm indication if one or more physiological parameters go beyond the safe level. It also employs a webcam to obtain the patient view at any time. LabVIEW enables the effortless interfacing of various biomedical sensors with the computer and provides high-speed data acquisition and interactive visualizations. It also provides a web publishing tool to access the interactive window remotely through a web browser. The web-based application is accessible to doctors who are experts in that particular field. They can obtain the real-time reading and directly perform a diagnosis. The parameters measured by the proposed system were validated using the traditional measurement systems, and the Root Mean Square (RMS) errors were obtained for the various parameters. The maximum RMS error as a percentage was 0.159%, which was found in the temperature measurement, and its power consumption is 1 Watt/h. The other RMS errors were 0.05% in measurement of systolic pressure, 0.029% in measurement of diastolic pressure, 0.059% in measurement of breathing rate, 0.002% in measurement of heart rate, 0.076% in measurement of oxygen level, and 0.015% in measurement of ECG. The low RMS errors and ease of deployment make it an attractive alternative for traditional monitoring systems. The proposed system has potential applications in hospitals, nursing homes, remote monitoring of the elderly, non-contact monitoring, etc

LI-Care: A LabVIEW and IoT Based eHealth Monitoring System

This paper presents a Laboratory Virtual Instrument Engineering Workbench (LabVIEW) and Internet of Things (IoT)-based eHealth monitoring system called LI-Care to facilitate the diagnosis of the health condition cost-effectively. The system measures the heart rate, body temperature, blood pressure, oxygen level, and breathing rate, and provides an electrocardiogram (ECG). The required sensors are integrated on a web-based application that keeps track of the essential parameters and gives an alarm indication if one or more physiological parameters go beyond the safe level. It also employs a webcam to obtain the patient view at any time. LabVIEW enables the effortless interfacing of various biomedical sensors with the computer and provides high-speed data acquisition and interactive visualizations. It also provides a web publishing tool to access the interactive window remotely through a web browser. The web-based application is accessible to doctors who are experts in that particular field. They can obtain the real-time reading and directly perform a diagnosis. The parameters measured by the proposed system were validated using the traditional measurement systems, and the Root Mean Square (RMS) errors were obtained for the various parameters. The maximum RMS error as a percentage was 0.159%, which was found in the temperature measurement, and its power consumption is 1 Watt/h. The other RMS errors were 0.05% in measurement of systolic pressure, 0.029% in measurement of diastolic pressure, 0.059% in measurement of breathing rate, 0.002% in measurement of heart rate, 0.076% in measurement of oxygen level, and 0.015% in measurement of ECG. The low RMS errors and ease of deployment make it an attractive alternative for traditional monitoring systems. The proposed system has potential applications in hospitals, nursing homes, remote monitoring of the elderly, non-contact monitoring, etc